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MECSPEC SIGNED

Interaction and feedback between cell mechanics and fate specification in vertebrate gastrulation

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

MECSPEC project word cloud

Explore the words cloud of the MECSPEC project. It provides you a very rough idea of what is the project "MECSPEC" about.

fundamental mathematical extensively gene functionally cell gastrulation mechanisms patterning interplay takes germ gastrula model vertebrate specification zebrafish feedback interaction physiological principles dissect physical explore underlying fate answers central developmental transdisciplinary close context embryo comparably signals back feed drives biology interact elucidate regulatory question progenitor onto networks combine embryogenesis modeling decades alterations shape layer unresolved organism mechanics scales dynamics little biophysical versa biological organization morphogenesis crosstalk genetic tissue vice experimentation

Project "MECSPEC" data sheet

The following table provides information about the project.

Coordinator	INSTITUTE OF SCIENCE AND TECHNOLOGY AUSTRIA Organization address address: Am Campus 1 city: KLOSTERNEUBURG postcode: 3400 website: www.ist.ac.at contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Austria [AT]
Project website	https://heisenberglab.pages.ist.ac.at/erc-advanced-grant/
Total cost	2˙306˙862 €
EC max contribution	2˙306˙862 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2016-ADG
Funding Scheme	ERC-ADG
Starting year	2017
Duration (year-month-day)	from 2017-07-01 to 2022-06-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	INSTITUTE OF SCIENCE AND TECHNOLOGY AUSTRIA INSTITUTE OF SCIENCE AND TECHNOLOGY AUSTRIA Organization address address: Am Campus 1 city: KLOSTERNEUBURG postcode: 3400 website: www.ist.ac.at contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AT (KLOSTERNEUBURG)	coordinator	2˙306˙862.00

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Project objective

Embryogenesis is achieved by the close interplay between the gene regulatory networks that control cell fate specification and the physical processes by which the embryo takes shape. While each of these systems has been extensively investigated over the past decades, comparably little is yet known about how they functionally interact across different scales of organization within the physiological context of the developing embryo. The central aim of this proposal is to elucidate the fundamental principles underlying the interaction and feedback between cell mechanics and fate specification during vertebrate gastrulation. Using zebrafish as a vertebrate model organism, we will explore how germ layer progenitor cell fate specification affects the physical processes by which the gastrula takes shape, and, vice versa, how alterations in cell/tissue mechanics feed back onto the gene regulatory networks and signals controlling progenitor cell fate specification during gastrulation. To dissect the fundamental mechanisms underlying this crosstalk, we will combine genetic, cell biological and biophysical experimentation with mathematical modeling. We expect that this transdisciplinary approach will provide answers to a central yet unresolved question in developmental biology: how the interplay between cell mechanics, dynamics and fate specification drives embryo morphogenesis and patterning.

Publications

List of publications.
year	authors and title	journal	last update
2019	Nicoletta I Petridou, Carlâ€Philipp Heisenberg Tissue rheology in embryonic organization published pages: , ISSN: 0261-4189, DOI: 10.15252/embj.2019102497	The EMBO Journal 38/20	2020-03-24
2019	Shayan Shamipour, Roland Kardos, Shi-Lei Xue, BjÃ¶rn Hof, Edouard Hannezo, Carl-Philipp Heisenberg Bulk Actin Dynamics Drive Phase Segregation in Zebrafish Oocytes published pages: 1463-1479.e18, ISSN: 0092-8674, DOI: 10.1016/j.cell.2019.04.030	Cell 177/6	2020-03-24
2019	Edouard Hannezo, Carl-Philipp Heisenberg Mechanochemical Feedback Loops in Development and Disease published pages: 12-25, ISSN: 0092-8674, DOI: 10.1016/j.cell.2019.05.052	Cell 178/1	2020-03-24
2019	Daniel ÄŒapek, Michael Smutny, Alexandra-Madelaine Tichy, Maurizio Morri, Harald Janovjak, Carl-Philipp Heisenberg Light-activated Frizzled7 reveals a permissive role of non-canonical wnt signaling in mesendoderm cell migration published pages: , ISSN: 2050-084X, DOI: 10.7554/elife.42093	eLife 8	2020-03-24
2019	Cornelia Schwayer, Shayan Shamipour, Kornelija Pranjic-Ferscha, Alexandra Schauer, Maria Balda, Masazumi Tada, Karl Matter, Carl-Philipp Heisenberg Mechanosensation of Tight Junctions Depends on ZO-1 Phase Separation and Flow published pages: 937-952.e18, ISSN: 0092-8674, DOI: 10.1016/j.cell.2019.10.006	Cell 179/4	2020-03-24
2019	Nicoletta I. Petridou, Silvia Grigolon, Guillaume Salbreux, Edouard Hannezo, Carl-Philipp Heisenberg Fluidization-mediated tissue spreading by mitotic cell rounding and non-canonical Wnt signalling published pages: 169-178, ISSN: 1465-7392, DOI: 10.1038/s41556-018-0247-4	Nature Cell Biology 21/2	2020-03-24
2019	Peng Xia, Daniel GÃ¼tl, Vanessa Zheden, Carl-Philipp Heisenberg Lateral Inhibition in Cell Specification Mediated by Mechanical Signals Modulating TAZ Activity published pages: , ISSN: 0092-8674, DOI: 10.1016/j.cell.2019.01.019	Cell	2020-03-24

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