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Epiherigans SIGNED

Writing, reading and managing stress with H3K9me

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EC-Contrib. €

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 Epiherigans project word cloud

Explore the words cloud of the Epiherigans project. It provides you a very rough idea of what is the project "Epiherigans" about.

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Project "Epiherigans" data sheet

The following table provides information about the project.

Coordinator
FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH FONDATION 

Organization address
address: MAULBEERSTRASSE 66
city: BASEL
postcode: 4058
website: www.fmi.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 2˙500˙000 €
 EC max contribution 2˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-ADG
 Funding Scheme ERC-ADG
 Starting year 2017
 Duration (year-month-day) from 2017-06-01   to  2022-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH FONDATION CH (BASEL) coordinator 2˙500˙000.00

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 Project objective

Epigenetic inheritance is the transmission of information, generally in the form of DNA methylation or post-translational modifications on histones that regulate the availability of underlying genetic information for transcription. RNA itself feeds back to contribute to histone modification. Sequence accessibility is both a matter of folding the chromatin fibre to alter access to recognition motifs, and the local concentration of factors needed for efficient transcriptional initiation, elongation, termination or mRNA stability. In heterochromatin we find a subset of regulatory factors in carefully balanced concentrations that are maintained in part by the segregation of active and inactive domains. Histone H3 K9 methylation is key to this compartmentation. C. elegans provides an ideal system in which to study chromatin-based gene repression. We have demonstrated that histone H3 K9 methylation is the essential signal for the sequestration of heterochromatin at the nuclear envelope in C. elegans. The recognition of H3K9me1/2/3 by an inner nuclear envelope-bound chromodomain protein, CEC-4, actively sequesters heterochromatin in embryos, and contributes redundantly in adult tissues. Epiherigans has the ambitious goal to determine definitively what targets H3K9 methylation, and identify its physiological roles. We will examine how this mark contributes to the epigenetic recognition of repeat vs non-repeat sequence, and mediates a stress-induced response to oxidative damage. We will examine the link between these and the spatial clustering of heterochromatic domains. Epiherigans will develop an integrated approach to identify in vivo the factors that distinguish repeats from non-repeats, self from non-self within genomes and will examine how H3K9me contributes to a persistent ROS or DNA damage stress response. It represents a crucial step towards understanding of how our genomes use heterochromatin to modulate, stabilize and transmit chromatin organization.

 Publications

year authors and title journal last update
List of publications.
2019 Jan Padeken, Peter Zeller, Benjamin Towbin, Iskra Katic, Veronique Kalck, Stephen P. Methot, Susan M. Gasser
Synergistic lethality between BRCA1 and H3K9me2 loss reflects satellite derepression
published pages: 436-451, ISSN: 0890-9369, DOI: 10.1101/gad.322495.118
Genes & Development 33/7-8 2020-02-05
2019 Colin E. Delaney, Stephen P. Methot, Micol Guidi, Iskra Katic, Susan M. Gasser, Jan Padeken
Heterochromatic foci and transcriptional repression by an unstructured MET-2/SETDB1 co-factor LIN-65
published pages: 820-838, ISSN: 0021-9525, DOI: 10.1083/jcb.201811038
The Journal of Cell Biology 218/3 2020-02-05
2019 Daphne S. Cabianca, Celia Muñoz-Jiménez, Véronique Kalck, Dimos Gaidatzis, Jan Padeken, Andrew Seeber, Peter Askjaer, Susan M. Gasser
Active chromatin marks drive spatial sequestration of heterochromatin in C. elegans nuclei
published pages: 734-739, ISSN: 0028-0836, DOI: 10.1038/s41586-019-1243-y
Nature 569/7758 2020-02-05

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