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NanoBeat SIGNED

Developing Smart 3D Scaffolds based on Conductive Polymers and Carbon Nanotubes for Cardiac Tissue Engineering

Total Cost €

EC-Contrib. €

Partnership

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NanoBeat project word cloud

Explore the words cloud of the NanoBeat project. It provides you a very rough idea of what is the project "NanoBeat" about.

heart hearts central biology materials cardiac outstanding polypyrrole brain carbon generate damage functional rat supports comprising cnt healthy scaffold nanomaterial cell morphologies engineering functions matrix cm biomaterial synthesized combination conductive nanotubes 3d electrical drug modify tool regeneration host cnts cells interact modified smart appear tissue profileration adult hypothesize diagnosis neonatal nanomedicine stimulus scaffolds vitro biosensing viability aftewards group responsing gained treatment myocytes cardiomyocites pedot exert barriers interactions cp biological repair nervous networks genetically electroactive vivo disease cross imaging adapt skeleton shapes implants polymers versatile

Project "NanoBeat" data sheet

The following table provides information about the project.

Coordinator	UNIVERSIDAD DEL PAIS VASCO/ EUSKAL HERRIKO UNIBERTSITATEA Organization address address: BARRIO SARRIENA S N city: LEIOA postcode: 48940 website: www.ehu.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Spain [ES]
Total cost	257˙191 €
EC max contribution	257˙191 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2016
Funding Scheme	MSCA-IF-GF
Starting year	2018
Duration (year-month-day)	from 2018-05-01 to 2021-04-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSIDAD DEL PAIS VASCO/ EUSKAL HERRIKO UNIBERTSITATEA UNIVERSIDAD DEL PAIS VASCO/ EUSKAL HERRIKO UNIBERTSITATEA Organization address address: BARRIO SARRIENA S N city: LEIOA postcode: 48940 website: www.ehu.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (LEIOA)	coordinator	257˙191.00
2	REGENTS OF THE UNIVERSITY OF COLORADO REGENTS OF THE UNIVERSITY OF COLORADO Organization address address: Marine Street - Room 479 3100 city: Boulder CO postcode: 80309-0572 website: www.colorado.edu/ocg contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	US (Boulder CO)	partner	0.00

Map

Project objective

Conductive polymers (CP) appear as promising stimulus-responsing electroactive biomaterial for profileration of cells. CP are versatile materials that can be synthesized in different shapes and morphologies, offering a wide range of application in biosensing, implants, drug delivery and tissue engineering. Carbon Nanotubes (CNTs) have become promising advanced materials and gained increasing importance for applications in nanomedicine, such as diagnosis, disease treatment, imaging, and tissue engineering. CNTs can interact with cells, cross the biological barriers, and modify their functions and biology. More recently, CNTs have become a new tool to specifically interact with the central nervous systems and support tissue repair after brain damage. Take into account of such findings, we hypothesize that CNTs exert functional effects on networks of cardiac myocytes and, in addition, the combination of those two materials will generate an outstanding scaffold for other electroactive cell growth, such as cardiac cells. In my current research, I have developed 3D scaffolds of CNT with a CP skeleton (polypyrrole or PEDOT) and aftewards, the goal of my research and thus the aim of the current proposal is to test such scaffolds for cardiac tissue regeneration. More specific aims are: 1) Adapt already developed smart “scaffold-matrix supports” for heart tissue engineering and test its viability, comprising CNT and conductive polymers. 2) In vitro and in vivo studies of healthy and genetically modified cardiomyocites (CM) of neonatal and adult rat hearts to determine the interactions between cells and the smart scaffolds and demonstrate that such devices promote heart cell growth and change their electrical properties. 3) Test other carbon nanomaterial scaffolds generated in the host group as supports for cardiac tissue engineering.

Publications

List of publications.
year	authors and title	journal	last update
2018	Nuria Alegret, Antonio Dominguez-Alfaro, David Mecerreyes 3D Scaffolds Based on Conductive Polymers for Biomedical Applications published pages: 73-89, ISSN: 1525-7797, DOI: 10.1021/acs.biomac.8b01382	Biomacromolecules 20/1	2019-10-15
2018	Nuria Alegret, Antonio Dominguez-Alfaro, Jose M. GonzÃ¡lez-DomÃnguez, Blanca Arnaiz, Unai CossÃo, Susanna Bosi, Ester VÃ¡zquez, Pedro Ramos-Cabrer, David Mecerreyes, Maurizio Prato Three-Dimensional Conductive Scaffolds as Neural Prostheses Based on Carbon Nanotubes and Polypyrrole published pages: 43904-43914, ISSN: 1944-8244, DOI: 10.1021/acsami.8b16462	ACS Applied Materials & Interfaces 10/50	2019-10-15

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The information about "NANOBEAT" are provided by the European Opendata Portal: CORDIS opendata.