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BrainDrain SIGNED

Translational implications of the discovery of brain-draining lymphatics

Total Cost €

EC-Contrib. €

Partnership

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BrainDrain project word cloud

Explore the words cloud of the BrainDrain project. It provides you a very rough idea of what is the project "BrainDrain" about.

serves sustained worldwide beta aggregates euros amyloid alleviates translational 800 human lack clearance position vessels therapeutic fluid proof models lymphatic lymphangiogenic mediated science postmortem received traumatic frontline parenchymal burden neurotoxic discovery suddenly alzheimer reassess population sclerosis meningeal brain feel pathogenesis drainage dynamics 2010 considerable translated cell immune socioeconomic mouse mice aging injury disease clinical newly discovered damage notable alleviate model medicine nature physiological neurodegenerative neuroinflammatory cerebrovascular accumulation tissues 2015 solute diseases trafficking breakthroughs lymphatics spent homeostasis multiple cellular macromolecules first expansion protein billion biomedical vascular

Project "BrainDrain" data sheet

The following table provides information about the project.

Coordinator	HELSINGIN YLIOPISTO Organization address address: YLIOPISTONKATU 3 city: HELSINGIN YLIOPISTO postcode: 14 website: www.helsinki.fi contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Finland [FI]
Total cost	2˙420˙429 €
EC max contribution	2˙420˙429 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2016-ADG
Funding Scheme	ERC-ADG
Starting year	2017
Duration (year-month-day)	from 2017-08-01 to 2022-07-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	HELSINGIN YLIOPISTO HELSINGIN YLIOPISTO Organization address address: YLIOPISTONKATU 3 city: HELSINGIN YLIOPISTO postcode: 14 website: www.helsinki.fi contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FI (HELSINGIN YLIOPISTO)	coordinator	2˙420˙429.00

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Project objective

In 2010, 800 billion Euros was spent on brain diseases in Europe and the cost is expected to increase due to the aging population. – Here I propose to exploit our new discovery for research to alleviate this disease burden. In work selected by Nature Medicine among the top 10 ”Notable Advances” and by Science as one of the 10 ”Breakthroughs of the year” 2015, we discovered a meningeal lymphatic vascular system that serves brain homeostasis. We want to reassess current concepts about cerebrovascular dynamics, fluid drainage and cellular trafficking in physiological conditions, in Alzheimer’s disease mouse models and in human postmortem tissues. First, we will study the development and properties of meningeal lymphatics and how they are sustained during aging. We then want to analyse the clearance of macromolecules and protein aggregates in Alzheimer’s disease in mice that lack the newly discovered meningeal lymphatic drainage system. We will study if growth factor-mediated expansion of lymphatic vessels alleviates the parenchymal accumulation of neurotoxic amyloid beta and pathogenesis of Alzheimer’s disease and brain damage after traumatic brain injury. We will further analyse the role of lymphangiogenic growth factors and lymphatic vessels in brain solute clearance, immune cell trafficking and in a mouse model of multiple sclerosis. The meningeal lymphatics could be involved in a number of neurodegenerative and neuroinflammatory diseases of considerable human and socioeconomic burden. Several of our previous concepts have already been translated to clinical development and we aim to develop proof-of-principle therapeutic concepts in this project. I feel that we are just now in a unique position to advance frontline European translational biomedical research in this suddenly emerging field, which has received great attention worldwide.

Publications

List of publications.
year	authors and title	journal	last update
2019	Daniel J. Crona, Andrew D. Skol, Veli-Matti LeppÃ¤nen, Dylan M. Glubb, Amy S. Etheridge, Eleanor Hilliard, Carol E. PeÃ±a, Yuri K. Peterson, Nancy Klauber-DeMore, Kari K. Alitalo, Federico Innocenti Genetic Variants of VEGFA and FLT4 Are Determinants of Survival in Renal Cell Carcinoma Patients Treated with Sorafenib published pages: 231-241, ISSN: 0008-5472, DOI: 10.1158/0008-5472.can-18-1089	Cancer Research 79/1	2020-03-24
2019	Ebba Brakenhielm, Kari Alitalo Cardiac lymphatics in health and disease published pages: 56-68, ISSN: 1759-5002, DOI: 10.1038/s41569-018-0087-8	Nature Reviews Cardiology 16/1	2020-03-24

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The information about "BRAINDRAIN" are provided by the European Opendata Portal: CORDIS opendata.