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New Chol SIGNED

Development of New therapies against cholangiopathies.

Total Cost €

EC-Contrib. €

Partnership

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New Chol project word cloud

Explore the words cloud of the New Chol project. It provides you a very rough idea of what is the project "New Chol" about.

group human shortage disorders autoimmune diversity treatment toxic transcriptomic bile accounting die therapies cholangiopathies primary mortality therapy toxin diseases liver prevents medicine cirrhosis list systematically morbidity advantage absence inherited cholangitis model platform transplant suitable functional tract cells death chronic ing transplantation uniquely tissue unexplored donors diverse syndrome source explore stem therapeutics biliary generate renewable cystic innovative sclerosing accumulation drug cholangiocytes atresia alagille translational first disease single developmental vitro basic create pluripotent cellular organ time ultimately idiopathic identification regenerative immunosuppression physiologically carry cell inducing patients fibrosis

Project "New Chol" data sheet

The following table provides information about the project.

Coordinator	THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE Organization address address: TRINITY LANE THE OLD SCHOOLS city: CAMBRIDGE postcode: CB2 1TN website: www.cam.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Total cost	2˙499˙111 €
EC max contribution	2˙499˙111 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2016-ADG
Funding Scheme	ERC-ADG
Starting year	2017
Duration (year-month-day)	from 2017-12-01 to 2022-11-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE Organization address address: TRINITY LANE THE OLD SCHOOLS city: CAMBRIDGE postcode: CB2 1TN website: www.cam.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (CAMBRIDGE)	coordinator	2˙499˙111.00

Map

Project objective

Cholangiopathies represent a diverse group of diseases affecting cholangiocytes which are the main cell type of the biliary tract. These disorders range from inherited (Cystic Fibrosis) and developmental (Alagille Syndrome, Biliary Atresia) to autoimmune (Primary Biliary Cirrhosis), idiopathic (Primary Sclerosing Cholangitis) and drug or toxin induced diseases. Cholangiopathies result in toxic bile accumulation in the liver inducing cell death and ultimately cirrhosis. They carry high morbidity and mortality, accounting for up to a third of chronic liver disorders. Whole liver transplantation remains the main treatment. However, organ transplant requires immunosuppression with significant side effects and an increasing number of patients die while on the transplant list due to the shortage of suitable donors. Finally, the absence of physiologically relevant in vitro systems to model and to study cholangiopathies prevents the development of new therapeutics while cell based therapy approach have been unexplored. Here, we propose to systematically address these challenges by developing a novel and innovative program of translational research focusing on cholangiopathies. We will first investigate the cellular and functional diversity of the biliary tract and its impact on disease by taking advantage of recent developments in single cell transcriptomic analyses. We will then use this basic knowledge to generate and to characterize for the first time a renewable source of cholangiocytes from human induced pluripotent stem cells and from biliary tissue. The resulting cells will be used to model cholangiopathies in vitro and to create a new platform for drug target identification. Finally, we will explore the potential for in vitro generated cholangiocytes to be used in regenerative medicine applications including cell based therapy. Overall this comprehensive program will uniquely path the way for the development of a whole range of new therapies for cholangiopathies.

Publications

List of publications.
year	authors and title	journal	last update
2018	Charis-Patricia Segeritz, Sheikh Tamir Rashid, Miguel Cardoso de Brito, Maria Paola Serra, Adriana Ordonez, Carola Maria Morell, Joseph E. Kaserman, Pedro Madrigal, Nicholas R.F. Hannan, Laurent Gatto, Lu Tan, Andrew A. Wilson, Kathryn Lilley, Stefan J. Marciniak, Bibek Gooptu, David A. Lomas, Ludovic Vallier hiPSC hepatocyte model demonstrates the role of unfolded protein response and inflammatory networks in Î±1-antitrypsin deficiency published pages: 851-860, ISSN: 0168-8278, DOI: 10.1016/j.jhep.2018.05.028	Journal of Hepatology 69/4	2020-01-28
2019	Loukia Yiangou, Rodrigo A. Grandy, Carola M. Morell, Rute A. Tomaz, Anna Osnato, Juned Kadiwala, Daniele Muraro, Jose Garcia-Bernardo, Shota Nakanoh, William G. Bernard, Daniel Ortmann, Davis J. McCarthy, Ingrid Simonic, Sanjay Sinha, Ludovic Vallier Method to Synchronize Cell Cycle of Human Pluripotent Stem Cells without Affecting Their Fundamental Characteristics published pages: 165-179, ISSN: 2213-6711, DOI: 10.1016/j.stemcr.2018.11.020	Stem Cell Reports 12/1	2020-01-28
2018	Alexander W. Justin, Kourosh Saeb-Parsy, Athina E. Markaki, Ludovic Vallier, Fotios Sampaziotis Advances in the generation of bioengineered bile ducts published pages: 1532-1538, ISSN: 0925-4439, DOI: 10.1016/j.bbadis.2017.10.034	Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1864/4	2020-01-28
2019	Judith Kraiczy, Alexander D.B. Ross, Jessica L. Forbester, Gordon Dougan, Ludovic Vallier, Matthias Zilbauer Genome-Wide EpigeneticÂ and Transcriptomic Characterization of Human-Induced Pluripotent Stem Cellâ€“Derived Intestinal Epithelial Organoids published pages: 285-288, ISSN: 2352-345X, DOI: 10.1016/j.jcmgh.2018.10.008	Cellular and Molecular Gastroenterology and Hepatology 7/2	2020-01-28
2019	Stephanie M. Linker, Lara Urban, Stephen J. Clark, Mariya Chhatriwala, Shradha Amatya, Davis J. McCarthy, Ingo Ebersberger, Ludovic Vallier, Wolf Reik, Oliver Stegle, Marc Jan Bonder Combined single-cell profiling of expression and DNA methylation reveals splicing regulation and heterogeneity published pages: , ISSN: 1474-760X, DOI: 10.1186/s13059-019-1644-0	Genome Biology 20/1	2020-01-28
2018	Alessandro Bertero, Stephanie Brown, Pedro Madrigal, Anna Osnato, Daniel Ortmann, Loukia Yiangou, Juned Kadiwala, Nina C. Hubner, Igor Ruiz de los Mozos, Christoph SadÃ©e, An-Sofie Lenaerts, Shota Nakanoh, Rodrigo Grandy, Edward Farnell, Jernej Ule, Hendrik G. Stunnenberg, Sasha Mendjan, Ludovic Vallier The SMAD2/3 interactome reveals that TGFÎ² controls m6A mRNA methylation in pluripotency published pages: 256-259, ISSN: 0028-0836, DOI: 10.1038/nature25784	Nature 555/7695	2020-01-28
2019	AngÃ©lique Fourrier, FrÃ©dÃ©ric Delbos, SÃ©verine Menoret, Camille Collet, Linh Trinh Thi Thuy, Anne Myara, FranÃ§ois Petit, Laia Tolosa, Sophie Laplanche, MarÃa JosÃ© GÃ³mezâ€LechÃ³n, Philippe Labrune, Ignacio Anegon, Ludovic Vallier, Delphine Garnier, Tuan Huy Nguyen Regenerative cell therapy for the treatment of hyperbilirubinemic Gunn rats with fresh and frozen human induced pluripotent stem cellsâ€derived hepatic stem cells published pages: , ISSN: 0908-665X, DOI: 10.1111/xen.12544	Xenotransplantation	2020-01-28
2018	Loukia Yiangou, Alexander D.B. Ross, Kim Jee Goh, Ludovic Vallier Human Pluripotent Stem Cell-Derived Endoderm for Modeling Development and Clinical Applications published pages: 485-499, ISSN: 1934-5909, DOI: 10.1016/j.stem.2018.03.016	Cell Stem Cell 22/4	2020-01-28

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