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Brain2Bee SIGNED

How dopamine affects social and motor ability - from the human brain to the honey bee

Total Cost €

EC-Contrib. €

Partnership

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Brain2Bee project word cloud

Explore the words cloud of the Brain2Bee project. It provides you a very rough idea of what is the project "Brain2Bee" about.

individuals difficulties blockers underappreciated drugs unpack da parkinson characterised reuptake psychopharmacology autism co combined model notably linked genes linking disparate clinical never elucidating exhibit caused dysfunction function unite disease expression synthesis inhibitors structure occurring critically sophisticated causal dopamine cascade motor patients animal impairment dopaminergic specificity strands events generalises unclear brain2bee biological predictions receptor occurrence symptoms variation bee refine usually contributions honey basis populations genetic social dams relationship

Project "Brain2Bee" data sheet

The following table provides information about the project.

Coordinator	THE UNIVERSITY OF BIRMINGHAM Organization address address: Edgbaston city: BIRMINGHAM postcode: B15 2TT website: www.bham.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Total cost	1˙783˙147 €
EC max contribution	1˙783˙147 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2017-STG
Funding Scheme	ERC-STG
Starting year	2018
Duration (year-month-day)	from 2018-07-01 to 2023-06-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	THE UNIVERSITY OF BIRMINGHAM THE UNIVERSITY OF BIRMINGHAM Organization address address: Edgbaston city: BIRMINGHAM postcode: B15 2TT website: www.bham.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (BIRMINGHAM)	coordinator	1˙751˙507.00
2	KING'S COLLEGE LONDON KING'S COLLEGE LONDON Organization address address: STRAND city: LONDON postcode: WC2R 2LS website: www.kcl.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	participant	31˙639.00

Map

Project objective

Parkinson’s Disease is usually characterised by motor impairment, and Autism by social difficulties. However, the co-occurrence of social and motor symptoms is critically underappreciated; Parkinson’s Disease patients exhibit social symptoms, and motor difficulties are common in Autism. At present, the biological basis of co-occurring social and motor impairment is unclear. Notably, both Autism and Parkinson’s Disease have been associated with dopamine (DA) system dysfunction and, in non-clinical populations, DA has been linked with social and motor ability. These disparate strands of research have never been combined.

Brain2Bee will use psychopharmacology in typical individuals to develop a model of the relationship between DA, Motor, and Social behaviour – the DAMS model. Brain2Bee will use sophisticated genetic analysis to refine DAMS, elucidating the contributions of DA-related biological processes (e.g. synthesis, receptor expression, reuptake). Brain2Bee will then test DAMS’ predictions in patients with Parkinson’s Disease and Autism. Finally, Brain2Bee will investigate whether DAMS generalises to an animal model, the honey bee, enabling future research to unpack the cascade of biological events linking DA-related genes with social and motor behaviour.

Brain2Bee will unite disparate research fields and establish the DAMS model. The causal structure of DAMS will identify the impact of dopaminergic variation on social and motor function in clinical and non-clinical populations, elucidating, for example, whether social difficulties in Parkinson’s Disease are a product of the motor difficulties caused by DA dysfunction. DAMS’ biological specificity will provide unique insight into the DA-related processes linking social and motor difficulties in Autism. Thus, Brain2Bee will determine the type of dopaminergic drugs (e.g. receptor blockers, reuptake inhibitors) most likely to improve both social and motor function.

Publications

List of publications.
year	authors and title	journal	last update
2019	Bianca Schuster, Sophie Sowden, Diar Abdlkarim, Alan Wing, Jennifer Cook Acting is not the same as feeling: Emotion expression in gait is different for posed and induced emotions published pages: , ISSN: 1662-5161, DOI: 10.3389/conf.fnhum.2019.229.00010	Frontiers in Human Neuroscience 13	2020-03-05
2019	Sophie Sowden, Bianca Schuster, Jennifer Cook The role of movement kinematics in facial emotion expression published pages: , ISSN: 1662-5161, DOI: 10.3389/conf.fnhum.2019.229.00018	Frontiers in Human Neuroscience 13	2020-03-05
2019	Jennifer L Cook, Jennifer C Swart, Monja I FrobÃ¶se, Andreea O Diaconescu, Dirk EM Geurts, Hanneke EM den Ouden, Roshan Cools Catecholaminergic modulation of meta-learning published pages: e51439, ISSN: 2050-084X, DOI: 10.7554/elife.51439	eLife 8	2020-03-05

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The information about "BRAIN2BEE" are provided by the European Opendata Portal: CORDIS opendata.