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HybridRetina SIGNED

Hybrid Retinal Prosthesis: High-Resolution Electrode Array Integrated with Neurons for Restoration of Sight

Total Cost €

EC-Contrib. €

Partnership

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HybridRetina project word cloud

Explore the words cloud of the HybridRetina project. It provides you a very rough idea of what is the project "HybridRetina" about.

resolution limitations coupling prostheses preserved circuits electrode neurons continuous bipolar bypassing ultimate integrate shift aforementioned retinitis stimulation hybrid activated photoreceptors charge patterned pigmentosa preserving overcoming prosthetic cells natural toward visual outer create 15 micro retina off implantation limited graded first pulsed relatively electrical paradigm density sight provides stimulated neuron implant neural coupled macular circuitry sensitivity activation diseases patients retinal implants distance array electrodes successful pixel quality degenerative vision dynamic fashion host acuity degeneration shown blind inner prosthetics proximity unprecedented degenerated tight restoration prosthesis technologies selective synapse age unrivalled

Project "HybridRetina" data sheet

The following table provides information about the project.

Coordinator	BAR ILAN UNIVERSITY Organization address address: BAR ILAN UNIVERSITY CAMPUS city: RAMAT GAN postcode: 52900 website: www.biu.ac.il contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Israel [IL]
Total cost	1˙499˙582 €
EC max contribution	1˙499˙582 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2017-STG
Funding Scheme	ERC-STG
Starting year	2018
Duration (year-month-day)	from 2018-05-01 to 2023-04-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	BAR ILAN UNIVERSITY BAR ILAN UNIVERSITY Organization address address: BAR ILAN UNIVERSITY CAMPUS city: RAMAT GAN postcode: 52900 website: www.biu.ac.il contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IL (RAMAT GAN)	coordinator	1˙499˙582.00

Map

Project objective

Vision restoration in patients with outer retinal degenerative diseases, such as Age-related Macular Degeneration and Retinitis Pigmentosa can be achieved by bypassing the degenerated photoreceptors and the electrical stimulation of the relatively well-preserved inner retina through electrode implants. Although current retinal prostheses have been shown to provide useful vision in blind patients, the obtained visual acuity and quality are still relatively low. Several challenges cannot be addressed with the current retinal prosthetic technologies. First, increasing the electrode density for achieving high visual acuity is limited by the distance between the electrodes and the target neurons. Second, electrical stimulation by the current technologies is not selective for specific retinal circuitry (e.g. ON and OFF pathways). Finally, retinal neurons are stimulated by pulsed rather than in a continuously graded potential fashion, which provides the photoreceptors with an unrivalled dynamic range and sensitivity in natural vision. Here we propose a paradigm shift toward sight restoration with a hybrid retinal prosthesis aimed at overcoming the aforementioned limitations. The hybrid implant is composed of a very high density electrode array (pixel distance of 15µm) coupled with neurons to create a tight neuron-electrode coupling. Following implantation of the hybrid prosthesis, the neurons integrate and synapse with the host retinal circuits. Upon patterned electrical stimulation of the neurons by the electrodes, the host bipolar cells are activated while preserving the natural vision circuits. The ultimate electrode-neurons proximity allows for the significant increase in pixel density, the low charge neural activation, and the continuous graded potential activation. This research can advance our knowledge in the retinal field and in other neural prosthetics and if successful, it will enable future vision restoration with unprecedented resolution.

Publications

List of publications.
year	authors and title	journal	last update
2020	Tamar Arens-Arad, Nairouz Farah, Rivkah Lender, Avital Moshkovitz, Thomas Flores, Daniel Palanker, Yossi Mandel Cortical Interactions between Prosthetic and Natural Vision published pages: 176-182.e2, ISSN: 0960-9822, DOI: 10.1016/j.cub.2019.11.028	Current Biology 30/1	2020-02-05
2019	Itai Henn, Ayelet Atkins, Amos Markus, Gal Shpun, Hannahâ€Noa Barad, Nairouz Farah, Yossi Mandel SEM/FIB Imaging for Studying Neural Interfaces published pages: , ISSN: 1932-846X, DOI: 10.1002/dneu.22707	Developmental Neurobiology	2020-02-05
2019	Adi Gross, Nadav H. Ivzan, Nairouz Farah, Yossi Mandel High-resolution VSDI retinotopic mapping via a DLP-based projection system published pages: 5117, ISSN: 2156-7085, DOI: 10.1364/boe.10.005117	Biomedical Optics Express 10/10	2020-02-05

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The information about "HYBRIDRETINA" are provided by the European Opendata Portal: CORDIS opendata.