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PRECALI SIGNED

PREeclampsia risk stratification test: development of a suitable CALIbration framework for the analysis of a multiplex panel of endogenous compounds by LC-MS

Total Cost €

EC-Contrib. €

Partnership

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PRECALI project word cloud

Explore the words cloud of the PRECALI project. It provides you a very rough idea of what is the project "PRECALI" about.

profiles mdx extensively lc applicable readily strategy regards accepted levels preeclampsia overcome endogenous clinical validation optimal underpinning innovative background classic metabolite scope equally perturbation internationally subsequent ms fed establishing she company difficult doctoral quantification team researcher explored predictive pregnancy delivering algorithm mass format data stratification enterprise framework multiplex panel consists risk stakeholders metabolites prerequisites limitations combine spectrometric perform tests calibration candidate appropriate eclampsia bioanalysis merely biomarker scientists dissertation entrepreneurs preeclmapsia occurring assays expertise compounds metabolomic perfect diagnostics

Project "PRECALI" data sheet

The following table provides information about the project.

Coordinator	METABOLOMIC DIAGNOSTICS LIMITED Organization address address: HOFFMAN PARK, INCHERA, LITTLE ISLAND city: Cork postcode: T12 website: www.metabolomicdiagnostics.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Ireland [IE]
Total cost	175˙866 €
EC max contribution	175˙866 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2017
Funding Scheme	MSCA-IF-EF-SE
Starting year	2018
Duration (year-month-day)	from 2018-06-01 to 2020-05-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	METABOLOMIC DIAGNOSTICS LIMITED METABOLOMIC DIAGNOSTICS LIMITED Organization address address: HOFFMAN PARK, INCHERA, LITTLE ISLAND city: Cork postcode: T12 website: www.metabolomicdiagnostics.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IE (Cork)	coordinator	175˙866.00

Map

Project objective

PREeclampsia risk stratification test: development of CALIbration framework for the analysis of a multiplex panel of endogenous Compounds by LC-MS. Metabolomic Diagnostics (MDx) is an innovative company which is developing tests for pre-eclampsia in pregnancy. MDx consists of a team of scientists and entrepreneurs with clinical support. The enterprise and the experienced researcher propose to combine their expertise to support the development of a robust test for the risk stratification of preeclampsia. One of the key challenges in the product development is establishing the optimal way to perform the quantification of the metabolite targets underpinning the preeclmapsia test.

In the case of risk stratification products, the predictive metabolite biomarker profiles are merely a perturbation in the levels of a set of endogenous occurring metabolites. As a result, the internationally well-established LC-MS test validation framework as known for bioanalysis is not readily applicable.

The researcher’s doctoral dissertation focused on the development and subsequent validation of novel mass spectrometric assays for endogenous metabolites and she explored a novel validation strategy to overcome the limitations of the classic bioanalysis validation framework with regards to validation mass spectrometric assays for endogenous compounds. It would be difficult for MDx to find a candidate with a more relevant background for this project and it would be equally difficult for the researcher to find a company in Europe with such a perfect project to implement her expertise extensively.

The scope of this project is the development of an appropriate quantification strategy for the product, with the following prerequisites: - 1. Delivering robust quantification data which can be fed to the product risk stratification algorithm - 2. Delivering robust quantification data in a format which can be accepted by key stakeholders

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The information about "PRECALI" are provided by the European Opendata Portal: CORDIS opendata.