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DEVINCI SIGNED

Developmental principles for the functional specialisation of inhibitory circuits in neocortical areas

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

DEVINCI project word cloud

Explore the words cloud of the DEVINCI project. It provides you a very rough idea of what is the project "DEVINCI" about.

sculpting containing though understand connectivity motor output neurons received differences cytoarchitectonical environment contribution inhibitory circuits arise associations specialisations pyramidal form little transforming computational cortical glutamatergic interneurons emphasis accompany reflect cortex comprise classes area neocortex hypothesise discrete differential functional majority made excitatory consists distinctive perhaps mammalian collectively gabaergic relative encode quantitative transform stimuli organisation layers cerebral cells mechanisms central interconnected tuning sensory drive neocortical play inputs context patterns heterogeneous six input tenet developmental largely contrast specialisation

Project "DEVINCI" data sheet

The following table provides information about the project.

Coordinator	KING'S COLLEGE LONDON Organization address address: STRAND city: LONDON postcode: WC2R 2LS website: www.kcl.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Project website	http://devneuro.org.uk/marinlab/Default.aspx
Total cost	2˙500˙000 €
EC max contribution	2˙500˙000 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2017-ADG
Funding Scheme	ERC-ADG
Starting year	2018
Duration (year-month-day)	from 2018-07-01 to 2023-06-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	KING'S COLLEGE LONDON KING'S COLLEGE LONDON Organization address address: STRAND city: LONDON postcode: WC2R 2LS website: www.kcl.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	coordinator	2˙500˙000.00

Map

Project objective

The mammalian neocortex consists of discrete, but highly interconnected, functional areas that collectively encode features of the environment, form associations between stimuli and drive behaviour by transforming sensory input into motor output. All neocortical areas are organised into six layers containing two major classes of neurons, excitatory glutamatergic pyramidal cells and inhibitory GABAergic interneurons. However, each area has distinctive cytoarchitectonical features and inputs that largely determine its computational capabilities. As pyramidal cells comprise the large majority of neurons in the cerebral cortex, much emphasis has been made on their contribution to the differential organisation of cortical areas. In contrast, interneurons have received little attention in the context of the functional specialisation of cortical areas, even though their distribution is highly heterogeneous.

The central tenet of this research proposal is that distinct patterns of inhibitory connectivity may accompany, and perhaps even determine, the functional specialisation of neocortical areas. We hypothesise that interneurons play an important role in the tuning of circuits in each cortical area, and therefore that quantitative differences in the relative distribution of specific classes of interneurons, which arise during development, reflect functional specialisations. The overall aim of this research project is to understand how developmental mechanisms ‘sculpting’ the distribution of inhibitory neurons across different neocortical areas contribute to their functional specialisation. This project has the potential to transform our understanding of the organisation of inhibitory circuits in the mammalian neocortex.

Deliverables

List of deliverables.
Data Management Plan	Open Research Data Pilot	2020-04-11 08:48:25

Take a look to the deliverables list in detail: detailed list of DEVINCI deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2019	Alfredo Llorca, Gabriele Ciceri, Robert Beattie, Fong Kuan Wong, Giovanni Diana, Eleni Serafeimidou-Pouliou, Marian FernÃ¡ndez-Otero, Carmen Streicher, Sebastian J Arnold, Martin Meyer, Simon Hippenmeyer, Miguel Maravall, Oscar Marin A stochastic framework of neurogenesis underlies the assembly of neocortical cytoarchitecture published pages: , ISSN: 2050-084X, DOI: 10.7554/elife.51381	eLife 8	2020-04-11
2018	Lynette Lim, Da Mi, Alfredo Llorca, Oscar MarÃn Development and Functional Diversification of Cortical Interneurons published pages: 294-313, ISSN: 0896-6273, DOI: 10.1016/j.neuron.2018.10.009	Neuron 100/2	2020-04-11
2019	Fong Kuan Wong, Oscar MarÃn Developmental Cell Death in the Cerebral Cortex published pages: 523-542, ISSN: 1081-0706, DOI: 10.1146/annurev-cellbio-100818-125204	Annual Review of Cell and Developmental Biology 35/1	2020-04-11

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