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EDCMET SIGNED

Metabolic effects of Endocrine Disrupting Chemicals: novel testing METhods and adverse outcome pathways

Total Cost €

EC-Contrib. €

Partnership

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EDCMET project word cloud

Explore the words cloud of the EDCMET project. It provides you a very rough idea of what is the project "EDCMET" about.

epidemiologists validated dyslipidemia toxicologists blood metabolism centre historically ultimately environmental interdisciplinary tissue vivo functions thereby gain organism assessing interface atherosclerosis outcome skills health biologists reflected hormones exposure endocrine purposes cluster risk abdominal regulatory alter methodological brings joint endocrinology molecular pressure syndrome chemicals disrupting experimental links incidence agencies obesity ed glucose progeny despite experts diabetes fasting vitro models mechanisms expertise exogenous metabolic jrc disease reproductive combined monitoring regarding outcomes eds xenobiotics complementary action adverse data lacking linking disruptors epidemiological silico liver causing thorough emphasis edcmet elevated adipose

Project "EDCMET" data sheet

The following table provides information about the project.

Coordinator	ITA-SUOMEN YLIOPISTO Organization address address: YLIOPISTONRANTA 1 E city: KUOPIO postcode: 70211 website: www.uef.fi contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Finland [FI]
Total cost	5˙980˙408 €
EC max contribution	5˙980˙408 € (100%)
Programme	1. H2020-EU.3.1.1. (Understanding health, wellbeing and disease)
Code Call	H2020-SC1-2018-Single-Stage-RTD
Funding Scheme	RIA
Starting year	2019
Duration (year-month-day)	from 2019-01-01 to 2023-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	ITA-SUOMEN YLIOPISTO ITA-SUOMEN YLIOPISTO Organization address address: YLIOPISTONRANTA 1 E city: KUOPIO postcode: 70211 website: www.uef.fi contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FI (KUOPIO)	coordinator	2˙065˙432.00
2	OULUN YLIOPISTO OULUN YLIOPISTO Organization address address: PENTTI KAITERAN KATU 1 city: OULU postcode: 90014 website: www.oulu.fi contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FI (OULU)	participant	870˙193.00
3	BUNDESINSTITUT FUER RISIKOBEWERTUNG BUNDESINSTITUT FUER RISIKOBEWERTUNG Organization address address: MAX DOHRN STRASSE 8-10 city: BERLIN postcode: 10589 website: www.bfr.bund.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (BERLIN)	participant	420˙000.00
4	UNIVERSITY OF LEEDS UNIVERSITY OF LEEDS Organization address address: WOODHOUSE LANE city: LEEDS postcode: LS2 9JT website: www.leeds.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LEEDS)	participant	401˙031.00
5	PAMGENE INTERNATIONAL BV PAMGENE INTERNATIONAL BV Organization address address: WOLVENHOEK 10-12 city: DEN HAAG postcode: 5211 HH website: www.pamgene.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (DEN HAAG)	participant	398˙000.00
6	WAGENINGEN UNIVERSITY WAGENINGEN UNIVERSITY Organization address address: DROEVENDAALSESTEEG 4 city: WAGENINGEN postcode: 6708 PB website: http://www.wageningenur.nl/nl.htm contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (WAGENINGEN)	participant	370˙000.00
7	AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS Organization address address: CALLE SERRANO 117 city: MADRID postcode: 28006 website: http://www.csic.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (MADRID)	participant	360˙050.00
8	EUROSAFE EUROSAFE Organization address address: PARC D ACTIVITE DE LA BRETECHE BATIMENT B1 city: SANT-GREGOIRE postcode: 35760 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (SANT-GREGOIRE)	participant	299˙187.00
9	NORGES TEKNISK-NATURVITENSKAPELIGE UNIVERSITET NTNU NORGES TEKNISK-NATURVITENSKAPELIGE UNIVERSITET NTNU Organization address address: HOGSKOLERINGEN 1 city: TRONDHEIM postcode: 7491 website: www.ntnu.no contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NO (TRONDHEIM)	participant	280˙003.00
10	EBERHARD KARLS UNIVERSITAET TUEBINGEN EBERHARD KARLS UNIVERSITAET TUEBINGEN Organization address address: GESCHWISTER-SCHOLL-PLATZ city: TUEBINGEN postcode: 72074 website: www.uni-tuebingen.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (TUEBINGEN)	participant	276˙510.00
11	UNIVERZITA KARLOVA UNIVERZITA KARLOVA Organization address address: OVOCNY TRH 560/5 city: PRAHA 1 postcode: 116 36 website: www.cuni.cz contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CZ (PRAHA 1)	participant	240˙000.00

Map

Project objective

Endocrine disruptors (EDs) are defined as exogenous chemicals that alter functions of the endocrine system, thereby causing adverse health effects in an organism or its progeny. Historically, the field of ED research has focused on reproductive endocrinology and related hormones, which is reflected in the regulatory test methods assessing endocrine effects of xenobiotics. However, recent evidence links increased incidence of metabolic syndrome (a cluster of metabolic risk factors including abdominal obesity, dyslipidemia, elevated blood pressure, and elevated fasting glucose) to EDs, increasing the incidence of atherosclerosis and type 2 diabetes. Despite these findings, adequate testing methods for metabolic effects of EDs are lacking. The project “Metabolic effects of Endocrine Disrupting Chemicals: novel testing METhods and adverse outcome pathways” (EDCMET) brings together experts in various research fields, including systems toxicologists, experimental biologists with a thorough understanding of the molecular mechanisms of metabolic disease and comprehensive in vitro and in vivo methodological skills and ultimately, epidemiologists linking environmental exposure to adverse metabolic outcomes. This proposal focuses on developing novel test methods and models to assess the metabolic effects of EDs. Combined in silico methods, in vitro and in vivo methods are developed with an emphasis on liver and adipose tissue and endocrine pathways related to their metabolism. In addition, epidemiological and field monitoring data is used to gain information regarding the exposure to chemicals and ED-related metabolic effects. The interdisciplinary approach and complementary expertise of the participants will identify novel mechanisms of action, and in collaboration with the European Commission Joint Research Centre (JRC) providing an interface between the programme and European regulatory agencies, novel validated test methods for regulatory purposes will be generated.

Deliverables

List of deliverables.
Initial press release	Websites, patent fillings, videos etc.	2020-03-06 19:02:44
Project website for internal access as well as for public access	Websites, patent fillings, videos etc.	2020-03-06 19:02:44
Formation of External Scientific Advisory Board	Documents, reports	2020-03-06 19:02:44
Data management plan	Open Research Data Pilot	2020-03-06 19:02:44

Take a look to the deliverables list in detail: detailed list of EDCMET deliverables.

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The information about "EDCMET" are provided by the European Opendata Portal: CORDIS opendata.