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BIND SIGNED

Brain Involvement iN Dystrophinopathies

Total Cost €

EC-Contrib. €

Partnership

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BIND project word cloud

Explore the words cloud of the BIND project. It provides you a very rough idea of what is the project "BIND" about.

blood debilitating co transformative improves individuals dystrophy disorders muscular weakness live progressive dmd morbidities therapies dystrophin postnatal deficiency restoration autism compulsive disability partnership childhood function time 50 criteria mice neurobehavioural isoform multiple patients neurodevelopmental proteins first offers central preclude cross efforts mutations protein site disorder cns brain expression independent considering deficit encompassing 25 phenotype duchenne neurobehavioral differentially model neurodegeneration dystrophins mouse groups obstacle advocacy localisation arising mutation muscle gender raises syndromes circuitries genetic reversibility gene intellectual meets obsessive gaps clinical isoforms possibility life hyperactivity barrier deep dystrophic outcome nervous

Project "BIND" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITY COLLEGE LONDON Organization address address: GOWER STREET city: LONDON postcode: WC1E 6BT website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Total cost	6˙716˙325 €
EC max contribution	6˙666˙325 € (99%)
Programme	1. H2020-EU.3.1.1. (Understanding health, wellbeing and disease)
Code Call	H2020-SC1-2019-Two-Stage-RTD
Funding Scheme	RIA
Starting year	2020
Duration (year-month-day)	from 2020-01-01 to 2023-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITY COLLEGE LONDON UNIVERSITY COLLEGE LONDON Organization address address: GOWER STREET city: LONDON postcode: WC1E 6BT website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	coordinator	1˙733˙428.00
2	ACADEMISCH ZIEKENHUIS LEIDEN ACADEMISCH ZIEKENHUIS LEIDEN Organization address address: ALBINUSDREEF 2 city: LEIDEN postcode: 2333 ZA website: www.lumc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (LEIDEN)	participant	1˙014˙553.00
3	CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS Organization address address: RUE MICHEL ANGE 3 city: PARIS postcode: 75794 website: www.cnrs.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	participant	498˙179.00
4	UNIVERSITE DE VERSAILLES SAINT-QUENTIN-EN-YVELINES. UNIVERSITE DE VERSAILLES SAINT-QUENTIN-EN-YVELINES. Organization address address: Avenue de Paris 55 city: VERSAILLES postcode: 78035 website: www.uvsq.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (VERSAILLES)	participant	472˙675.00
5	UNIVERSITY OF NEWCASTLE UPON TYNE UNIVERSITY OF NEWCASTLE UPON TYNE Organization address address: KINGS GATE city: NEWCASTLE UPON TYNE postcode: NE1 7RU website: http://www.ncl.ac.uk/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (NEWCASTLE UPON TYNE)	participant	470˙980.00
6	CONSORZIO FUTURO IN RICERCA CONSORZIO FUTURO IN RICERCA Organization address address: VIA G SARAGAT 1 BLOCCO B city: FERRARA postcode: 44122 website: www.consorzioferrararicerche.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (FERRARA)	participant	334˙000.00
7	STICHTING KEMPENHAEGHE STICHTING KEMPENHAEGHE Organization address address: STERKSELSEWEG 65 city: HEEZE postcode: 5590 AB website: www.kempenhaeghe.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (HEEZE)	participant	304˙437.00
8	REGION HOVEDSTADEN REGION HOVEDSTADEN Organization address address: KONGENS VAENGE 2 city: HILLEROD postcode: 3400 website: www.regionh.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (HILLEROD)	participant	285˙207.00
9	TRANSPHARMATION IRELAND LTD TRANSPHARMATION IRELAND LTD Organization address address: 3RD FLOOR ULYSSES HOUSE FOLEY STREET city: DUBLIN postcode: D01 W2T2 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IE (DUBLIN)	participant	272˙445.00
10	THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN Organization address address: College Green city: DUBLIN postcode: 2 website: www.tcd.ie contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IE (DUBLIN)	participant	253˙508.00
11	UNIVERSITA CATTOLICA DEL SACRO CUORE UNIVERSITA CATTOLICA DEL SACRO CUORE Organization address address: Largo Agostino Gemelli 1 city: MILANO postcode: 20123 website: www.unicattolica.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (MILANO)	participant	183˙500.00
12	UNIVERSIDAD COMPLUTENSE DE MADRID UNIVERSIDAD COMPLUTENSE DE MADRID Organization address address: AVENIDA DE SENECA 2 city: MADRID postcode: 28040 website: http://www.ucm.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (MADRID)	participant	179˙125.00
13	IMAGINE INSTITUT DES MALADIES GENETIQUES NECKER ENFANTS MALADES FONDATION IMAGINE INSTITUT DES MALADIES GENETIQUES NECKER ENFANTS MALADES FONDATION Organization address address: 24 BD DU MONTPARNASSE city: PARIS 15 postcode: 75015 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS 15)	participant	166˙250.00
14	STICHTING UNITED PARENT PROJECTS MUSCULAR DYSTROPHY STICHTING UNITED PARENT PROJECTS MUSCULAR DYSTROPHY Organization address address: KONINGINNELAAN 69 city: VEENENDAAL postcode: 3905 GG website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (VEENENDAAL)	participant	165˙687.00
15	STICHTING DUCHENNE DATA FOUNDATION STICHTING DUCHENNE DATA FOUNDATION Organization address address: WARMOESDREEF 10 city: BERGEN OP ZOOM postcode: 4614 HC website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (BERGEN OP ZOOM)	participant	137˙687.00
16	SYNTHENA AG SYNTHENA AG Organization address address: FREIESTRASSE 3 city: BERN postcode: 3012 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (BERN)	participant	100˙000.00
17	PEPGEN LIMITED PEPGEN LIMITED Organization address address: BIOESCALITOR INNOVATION BUILDING O city: OXFORD postcode: OX37FZ website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (OXFORD)	participant	53˙563.00
18	GREAT ORMOND STREET HOSPITAL FOR CHILDREN NHS FOUNDATION TRUST GREAT ORMOND STREET HOSPITAL FOR CHILDREN NHS FOUNDATION TRUST Organization address address: GREAT ORMOND STREET city: LONDON postcode: WC1N 3JH website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	participant	41˙096.00
19	NATIONAL CENTER OF NEUROLOGY AND PSYCHIATRY NATIONAL CENTER OF NEUROLOGY AND PSYCHIATRY Organization address address: 4-1-1 OGAWA HIGASHI city: KODAIRA TOKYO postcode: 187 8502 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	JP (KODAIRA TOKYO)	participant	0.00

Map

Project objective

Duchenne muscular dystrophy (DMD) is the most common muscular dystrophy in childhood, with more than 25,000 patients in Europe. It is due to mutations in the DMD gene that preclude the production of the protein dystrophin. In addition to the progressive muscle weakness, 50% of affected individuals have debilitating central nervous system (CNS) co-morbidities, including intellectual disability, neurodevelopmental problems encompassing autism, Attention Deficit Hyperactivity Disorder and Obsessive Compulsive Disorder. These co-morbidities are due to the deficiency of multiple dystrophin isoforms in brain whose expression is differentially affected by the site of the DMD mutation. They represent a major obstacle for patients to live a fully independent life. Current therapies do not address these co-morbidities. The postnatal restoration of one dystrophin isoform using genetic therapies in the DMD mouse model improves the neurobehavioral phenotype. This raises the exciting possibility that some of the CNS co-morbidities could improve with genetic therapies in patients. We need to address several knowledge gaps before considering clinical applications of these therapies: i. dystrophin isoforms localisation in the CNS; ii. which of the neurobehavioural features of the dystrophic mice improve after dystrophin restoration, and circuitries involved; iii. deep phenotype patients to define robust outcome measures. This project developed in partnership with advocacy groups, meets gender criteria and offers for the first time insight into how dystrophins’ affect CNS function, and on the reversibility of the DMD CNS co-morbidities, providing essential information to the field of neurodevelopmental disorders, and for other syndromes arising from dystrophin associated proteins. Our efforts to develop novel therapies that can cross the blood brain barrier could be transformative for the field of neurodegeneration and neurodevelopmental disorders.

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The information about "BIND" are provided by the European Opendata Portal: CORDIS opendata.