#	Pagina
attuale pagina	/open-h2020/projects/219066/index.html

Opendata, web and dolomites

SiMBiT SIGNED

Single molecule bio-electronic smart system array for clinical testing

Total Cost €

EC-Contrib. €

Partnership

Views

SiMBiT project word cloud

Explore the words cloud of the SiMBiT project. It provides you a very rough idea of what is the project "SiMBiT" about.

enhanced settings direct materials limited digitizing ic frontier pancreatic writing module resource chemists scalable genomic time smart clinicians coming leveraging electronic portable mass physicists techniques precision array modular bio protein molecule limits interfaces science effort simbit simultaneous advancing health standard perform si quantifying foreseen dna biomarkers device multidisciplinary matrix prototype human first platform exhibits area proteins neoplasms data world chip lab 96 single proof detection assay engineers clinical context volume performing specificity minimized compatible sensing multiplexing printing minimal integrates goals fabricated hours 3d sensors analytical components pins markers plate manufacturable effect

Project "SiMBiT" data sheet

The following table provides information about the project.

Coordinator	CONSORZIO INTERUNIVERSITARIO PERLO SVILUPPO DEI SISTEMI A GRANDE INTERFASE Organization address address: VIA DELLA LASTRUCCIA 3 city: FIRENZE postcode: 50019 website: www.csgi.unifi.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Italy [IT]
Total cost	3˙020˙638 €
EC max contribution	3˙020˙638 € (100%)
Programme	1. H2020-EU.2.1.1. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies - Information and Communication Technologies (ICT))
Code Call	H2020-ICT-2018-2
Funding Scheme	RIA
Starting year	2019
Duration (year-month-day)	from 2019-01-01 to 2022-06-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	CONSORZIO INTERUNIVERSITARIO PERLO SVILUPPO DEI SISTEMI A GRANDE INTERFASE CONSORZIO INTERUNIVERSITARIO PERLO SVILUPPO DEI SISTEMI A GRANDE INTERFASE Organization address address: VIA DELLA LASTRUCCIA 3 city: FIRENZE postcode: 50019 website: www.csgi.unifi.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (FIRENZE)	coordinator	390˙750.00
2	HEINRICH-HEINE-UNIVERSITAET DUESSELDORF HEINRICH-HEINE-UNIVERSITAET DUESSELDORF Organization address address: UNIVERSITAETSSTRASSE 1 city: DUSSELDORF postcode: 40225 website: www.uni-duesseldorf.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (DUSSELDORF)	participant	415˙765.00
3	UNIVERSITA DEGLI STUDI DI BRESCIA UNIVERSITA DEGLI STUDI DI BRESCIA Organization address address: PIAZZA MERCATO 15 city: BRESCIA postcode: 25121 website: www.unibs.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (BRESCIA)	participant	391˙221.00
4	TECHNISCHE UNIVERSITEIT EINDHOVEN TECHNISCHE UNIVERSITEIT EINDHOVEN Organization address address: GROENE LOPER 3 city: EINDHOVEN postcode: 5612 AE website: www.tue.nl/en contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (EINDHOVEN)	participant	389˙998.00
5	FLEXENABLE LIMITED FLEXENABLE LIMITED Organization address address: 34 CAMBRIDGE SCIENCE PARK, MILTON ROAD city: CAMBRIDGE postcode: CB4 0FX website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (CAMBRIDGE)	participant	355˙403.00
6	FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA Organization address address: VIA MOREGO 30 city: GENOVA postcode: 16163 website: www.iit.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (GENOVA)	participant	352˙500.00
7	ABO AKADEMI ABO AKADEMI Organization address address: DOMKYRKOTORGET 3 city: ABO postcode: 20500 website: http://www.abo.fi contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FI (ABO)	participant	350˙000.00
8	MASMEC SPA MASMEC SPA Organization address address: VIA DEI GIGLI 21 city: MODUGNO postcode: 70026 website: www.masmec.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (MODUGNO)	participant	262˙500.00
9	EFFICIENT INNOVATION SAS EFFICIENT INNOVATION SAS Organization address address: AVENUE CLEMENT ADER 55 city: CASTELNAU LE LEZ postcode: 34170 website: www.efficient-innovation.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (CASTELNAU LE LEZ)	participant	112˙500.00

Map

Project objective

Digitizing biomarkers analysis by quantifying them at the single-molecule level is the new frontier for advancing the science of precision health. The SiMBiT project will develop a bio-electronic smart system leveraging on an existing lab-based proof-of-concept that can perform single-molecule detection of both proteins and DNA bio-markers. Specifically, the SiMBiT activities will develop the lab-based device into a cost-effective portable multiplexing array prototype that integrates, with a modular approach, novel materials and standard components/interfaces. The SiMBiT platform exhibits enhanced sensing capabilities: specificity towards both genomic and protein markers along with single-molecule detection limits and time-to-results within two hours. This makes the SiMBiT prototype the world best performing bio-electronic sensing system ever. SiMBiT will reach these ambitious goals with a multidisciplinary research effort involving device-physicists, analytical-chemists, bio-chemists, clinicians, electronic- and system-engineers. The platform is also single-use and cost-effective and can work in low-resource settings. The SiMBiT field-effect sensing system will be fabricated by means of future mass-manufacturable, large-area compatible, scalable techniques such as printing and other direct-writing processes. 3D printing of a module is also foreseen. The SiMBiT prototype will demonstrate, for first time, a matrix of up to 96 bio-electronic sensors and a Si IC chip for the processing of all data coming from the matrix, multiplexing single-molecule detection. As the Si IC pins are limited the chip area is reduced and its cost minimized, enabling a single-use assay plate. SiMBiT will apply the multiplexing single molecule technology to the early detection of human pancreatic neoplasms in a well-defined clinical context, performing simultaneous analysis of genomic and protein markers with a minimal sample volume, reduced costs and reduced time-to-results.

Publications

List of publications.
year	authors and title	journal	last update
2019	Eleonora Macchia, Kyriaki Manoli, Brigitte Holzer, Cinzia Di Franco, Rosaria A. Picca, Nicola Cioffi, Gaetano Scamarcio, Gerardo Palazzo, Luisa Torsi Selective single-molecule analytical detection of C-reactive protein in saliva with an organic transistor published pages: 4899-4908, ISSN: 1618-2642, DOI: 10.1007/s00216-019-01778-2	Analytical and Bioanalytical Chemistry 411/19	2020-03-05
2019	Rosaria Anna Picca, Kyriaki Manoli, Eleonora Macchia, Angelo Tricase, Cinzia Di Franco, Gaetano Scamarcio, Nicola Cioffi, Luisa Torsi A Study on the Stability of Water-Gated Organic Field-Effect-Transistors Based on a Commercial p-Type Polymer published pages: , ISSN: 2296-2646, DOI: 10.3389/fchem.2019.00667	Frontiers in Chemistry 7	2020-03-05
2018	Eleonora Macchia, Amber Tiwari, Kyriaki Manoli, Brigitte Holzer, Nicoletta Ditaranto, Rosaria Anna Picca, Nicola Cioffi, Cinzia Di Franco, Gaetano Scamarcio, Gerardo Palazzo, Luisa Torsi Label-Free and Selective Single-Molecule Bioelectronic Sensing with a Millimeter-Wide Self-Assembled Monolayer of Anti-Immunoglobulins published pages: 6476-6483, ISSN: 0897-4756, DOI: 10.1021/acs.chemmater.8b04414	Chemistry of Materials 31/17	2020-03-05
2020	Eleonora Macchia, Lucia Sarcina, Rosaria Anna Picca, Kyriaki Manoli, Cinzia Di Franco, Gaetano Scamarcio, Luisa Torsi Ultra-low HIV-1 p24 detection limits with a bioelectronic sensor published pages: 811-818, ISSN: 1618-2642, DOI: 10.1007/s00216-019-02319-7	Analytical and Bioanalytical Chemistry 412/4	2020-03-05
2019	Rosaria Anna Picca, Kyriaki Manoli, Eleonora Macchia, Lucia Sarcina, Cinzia Di Franco, Nicola Cioffi, Davide Blasi, Ronald Ã–sterbacka, Fabrizio Torricelli, Gaetano Scamarcio, Luisa Torsi Ultimately Sensitive Organic Bioelectronic Transistor Sensors by Materials and Device Structures\' Design published pages: 1904513, ISSN: 1616-301X, DOI: 10.1002/adfm.201904513	Advanced Functional Materials	2020-03-05
2019	K. Ebner, C. Driescher, W. Goering, L. Haeberle, V. Keitel, D. Haeussinger, I. Esposito. Case report: NGS of cell-free DNA from blood and bile as a follow-up strategy in a patient with metastatic pancreatic adenocarcinoma published pages: S235, ISSN: , DOI:	Virchows Archiv	2020-03-05
2019	C. Driescher, K. Ebner, W. Goering, L. Haeberle, V. Keitel, D. Haeussinger, I. Esposito Exploitation of cfDNA extracted from bile as liquid biopsy source in pancreatobiliary cancers published pages: S62, ISSN: , DOI:	Virchows Archiv	2020-03-05

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "SIMBIT" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "SIMBIT" are provided by the European Opendata Portal: CORDIS opendata.