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Andrea SIGNED

A Novel Detection protocols for REliable prostate cancer Assays

Total Cost €

EC-Contrib. €

Partnership

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Andrea project word cloud

Explore the words cloud of the Andrea project. It provides you a very rough idea of what is the project "Andrea" about.

ing inaccurate lectins stage unreliable proteins biopsies newly epo which covered start samples compatible glycanostics guide platform prostate needless diagnostic pca patent statistical innovative performed assay glycoprofiling cancer diagnostics inventive retrospective 450 successfully biopsy psa commercial format incorporated rival kit validation filed serum grant office biomarker roc uses human com ltd right indicating curve receiver validated commercialisation decision clinical kits opinion poc describes ongoing

Project "Andrea" data sheet

The following table provides information about the project.

Coordinator	CHEMICKY USTAV SLOVENSKEJ AKADEMIEVIED Organization address address: DUBRAVSKA CESTA 9 city: BRATISLAVA postcode: 845 website: www.chem.sk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Slovakia [SK]
Total cost	149˙499 €
EC max contribution	149˙499 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2018-PoC
Funding Scheme	ERC-POC
Starting year	2018
Duration (year-month-day)	from 2018-12-01 to 2020-05-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	CHEMICKY USTAV SLOVENSKEJ AKADEMIEVIED CHEMICKY USTAV SLOVENSKEJ AKADEMIEVIED Organization address address: DUBRAVSKA CESTA 9 city: BRATISLAVA postcode: 845 website: www.chem.sk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SK (BRATISLAVA)	coordinator	87˙500.00
2	GLYCANOSTICS SRO GLYCANOSTICS SRO Organization address address: DUBRAVSKA CESTA 9 city: BRATISLAVA postcode: 845 38 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SK (BRATISLAVA)	participant	61˙999.00

Map

Project objective

The technology validation was successfully completed indicating a great commercial potential, and the innovative and inventive aspects of the assay platform are now covered by the filed priority European Patent Office (EPO) patent applications. Validated glycoprofiling of the proteins now uses lectins in a format, fully compatible with clinical PSA assay kits. This PoC grant focuses on 1. Pre-clinical retrospective validation of the early stage biomarker of prostate cancer (PCa) and 2. Commercialisation of the PCa diagnostics kit. Pre-clinical (60 human serum samples) is ongoing and retrospective validation study (450 human serum samples) of the assay will be performed by statistical analysis using a receiver operating characteristic (ROC) curve. The PoC describes all steps, which have been developed so far and all necessary steps, which need to be done for retrospective validation study, product development and commercialisation through our newly incorporated start-up Glycanostics Ltd. (www.glycanostics.com). We will provide PCa diagnostic test resulting in a second opinion to guide the right decision if the biopsy is needed. This will avoid the needless and unreliable biopsies and in the future rival an inaccurate PSA testing.

Publications

List of publications.
year	authors and title	journal	last update
2019	Tomas Bertok, Lenka Lorencova, Stefania Hroncekova, Veronika Gajdosova, Eduard Jane, Michal Hires, Peter Kasak, Ondrej Kaman, Roman Sokol, Vladimir Bella, Anita Andicsova Eckstein, Jaroslav Mosnacek, Alica Vikartovska, Jan Tkac Synthesis and characterization of Au nanoshells with a magnetic core and betaine derivatives published pages: 1999-2012, ISSN: 2215-0161, DOI: 10.1016/j.mex.2019.08.017	MethodsX 6	2019-12-16
2019	Jan Tkac, Veronika Gajdosova, Stefania Hroncekova, Tomas Bertok, Michal Hires, Eduard Jane, Lenka Lorencova, Peter Kasak Prostate-specific antigen glycoprofiling as diagnostic and prognostic biomarker of prostate cancer published pages: 20180077, ISSN: 2042-8898, DOI: 10.1098/rsfs.2018.0077	Interface Focus 9/2	2019-12-16
2019	Tomas Bertok, Lenka Lorencova, Stefania Hroncekova, Veronika Gajdosova, Eduard Jane, Michal Hires, Peter Kasak, Ondrej Kaman, Roman Sokol, Vladimir Bella, Anita Andicsova Eckstein, Jaroslav Mosnacek, Alica Vikartovska, Jan Tkac Advanced impedimetric biosensor configuration and assay protocol for glycoprofiling of a prostate oncomarker using Au nanoshells with a magnetic core published pages: 24-29, ISSN: 0956-5663, DOI: 10.1016/j.bios.2019.01.052	Biosensors and Bioelectronics 131	2019-12-16
2018	Jan Tkac, Tomas Bertok, Michal Hires, Eduard Jane, Lenka Lorencova, Peter Kasak Glycomics of prostate cancer: updates published pages: 65-76, ISSN: 1478-9450, DOI: 10.1080/14789450.2019.1549993	Expert Review of Proteomics 16/1	2019-12-16

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The information about "ANDREA" are provided by the European Opendata Portal: CORDIS opendata.