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DiSCo MRI SFN SIGNED

Developing Integrated Susceptibility and Conductivity MRI for Next Generation Structural and Functional Neuroimaging

Total Cost €

EC-Contrib. €

Partnership

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DiSCo MRI SFN project word cloud

Explore the words cloud of the DiSCo MRI SFN project. It provides you a very rough idea of what is the project "DiSCo MRI SFN" about.

building neurodegenerative electrical scan ad intervention rsfsm magnetic maximise totally resting first prevalence tissue electromagnetic simultaneous ideal blood composition reflects functional leader technique sensitive content cellular connectivity mri iron 3t biomarkers conductivity rsfmri networks promise poorly multimodal continue economic disruption yield combined stimulation separate characterisation brain diseases reveals tesla probably socio background breaking efficient therapeutic consuming removal extend integrate initial cm underlie applicability uniquely noise fsm time reveal fmri contrasts ground mapping techniques neuroimaging pioneered patients susceptibility diagnosis indispensable vision alzheimer burden sm structural physiological

Project "DiSCo MRI SFN" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITY COLLEGE LONDON Organization address address: GOWER STREET city: LONDON postcode: WC1E 6BT website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Total cost	1˙721˙726 €
EC max contribution	1˙721˙726 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2017-COG
Funding Scheme	ERC-COG
Starting year	2019
Duration (year-month-day)	from 2019-04-01 to 2024-03-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITY COLLEGE LONDON UNIVERSITY COLLEGE LONDON Organization address address: GOWER STREET city: LONDON postcode: WC1E 6BT website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	coordinator	1˙721˙726.00

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Project objective

MRI is indispensable in the diagnosis of neurodegenerative diseases. These are poorly understood while their prevalence and socio-economic burden continue to rise. Structural and functional MRI can provide biomarkers for early diagnosis and potential therapeutic intervention. My research vision is to develop novel MRI methods for structural and functional mapping of tissue magnetic susceptibility and electrical conductivity as these show great promise for neuroimaging in diseases such as Alzheimer’s (AD).

Susceptibility mapping (SM), which I pioneered, is uniquely sensitive to tissue composition including iron content affected in AD while conductivity mapping (CM) probably reflects cellular disruption in AD. Resting-state functional MRI (rsfMRI) reveals how AD affects brain networks without any tasks or stimulation equipment. However, each technique currently needs a separate time-consuming MRI scan. I will develop an integrated scan for simultaneous structural SM and CM, and rsfMRI functional connectivity characterisation. This efficient scan, ideal for AD patients, will reveal totally new resting-state networks based on electromagnetic properties: resting-state functional SM and resting-state functional CM for the first time. As changes in blood susceptibility underlie fMRI, rsfSM should measure functional connectivity more directly. This also makes it sensitive to physiological noise so I will develop noise removal methods building on fMRI techniques I established. Initial fSM studies have been at 7 Tesla but I will target the more widespread 3T field to maximise applicability. As a leader in both SM and rsfMRI physiological noise removal I have the ideal background to integrate SM and CM with fMRI and extend them for ground-breaking functional electromagnetic connectivity. This research will yield a rich set of novel, multimodal MRI contrasts to allow development of new combined structural and functional biomarkers for early diagnosis of AD and other diseases.

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The information about "DISCO MRI SFN" are provided by the European Opendata Portal: CORDIS opendata.