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BETTER-B SIGNED

BETTER TREATMENTS FOR BREATHLESSNESS IN PALLIATIVE AND END OF LIFE CARE

Total Cost €

EC-Contrib. €

Partnership

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BETTER-B project word cloud

Explore the words cloud of the BETTER-B project. It provides you a very rough idea of what is the project "BETTER-B" about.

suggest survey scientists widest alongside physical optimal antidepressant pulmonary needing detrimental ensures unites disease emergency services chronic offers ireland conduct group guidance patient lung care internationally placebo blind uk double medicine carers accessible disciplinary patients feasibility time purpose 18 reviews 324 versus obstructive symptom society operation interstitial mirtazapine family friends germany wellbeing geriatric persists morbidity sustained licenced caregivers rehabilitation community quality despite treating life statisticians frightening refractory ild treatment respiratory clinicians distresses palliative copd psychosocial clinician world economists groups medicines underlying reduce months recruits clinical health cb tests poland randomised italy trial trialists breathlessness

Project "BETTER-B" data sheet

The following table provides information about the project.

Coordinator	KING'S COLLEGE LONDON Organization address address: STRAND city: LONDON postcode: WC2R 2LS website: www.kcl.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Total cost	3˙791˙503 €
EC max contribution	3˙769˙999 € (99%)
Programme	1. H2020-EU.3.1.3. (Treating and managing disease)
Code Call	H2020-SC1-2018-Single-Stage-RTD
Funding Scheme	RIA
Starting year	2019
Duration (year-month-day)	from 2019-01-01 to 2022-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	KING'S COLLEGE LONDON KING'S COLLEGE LONDON Organization address address: STRAND city: LONDON postcode: WC2R 2LS website: www.kcl.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	coordinator	1˙395˙122.00
2	UNIVERSITY OF LEEDS UNIVERSITY OF LEEDS Organization address address: WOODHOUSE LANE city: LEEDS postcode: LS2 9JT website: www.leeds.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LEEDS)	participant	669˙111.00
3	UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN Organization address address: BELFIELD city: DUBLIN postcode: 4 website: www.ucd.ie contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IE (DUBLIN)	participant	476˙203.00
4	AZIENDA UNITA SANITARIA LOCALE DI REGGIO EMILIA AZIENDA UNITA SANITARIA LOCALE DI REGGIO EMILIA Organization address address: VIA AMENDOLA 2 city: REGGIO EMILIA postcode: 42100 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (REGGIO EMILIA)	participant	283˙960.00
5	LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN Organization address address: GESCHWISTER SCHOLL PLATZ 1 city: MUENCHEN postcode: 80539 website: www.uni-muenchen.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (MUENCHEN)	participant	230˙812.00
6	KLINIKUM DER UNIVERSITAET ZU KOELN KLINIKUM DER UNIVERSITAET ZU KOELN Organization address address: Kerpener Strasse 62 city: KOELN postcode: 50937 website: www.uk-koeln.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (KOELN)	participant	170˙383.00
7	THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN Organization address address: College Green city: DUBLIN postcode: 2 website: www.tcd.ie contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IE (DUBLIN)	participant	109˙671.00
8	THE UNIVERSITY OF NOTTINGHAM THE UNIVERSITY OF NOTTINGHAM Organization address address: University Park city: NOTTINGHAM postcode: NG7 2RD website: www.nottingham.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (NOTTINGHAM)	participant	106˙095.00
9	GDANSKI UNIWERSYTET MEDYCZNY GDANSKI UNIWERSYTET MEDYCZNY Organization address address: ULICA M SKLODOWSKIEJ CURIE 3A city: GDANSK postcode: 80210 website: http://www.amg.gda.pl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	PL (GDANSK)	participant	97˙612.00
10	UNIVERSITA CATTOLICA DEL SACRO CUORE UNIVERSITA CATTOLICA DEL SACRO CUORE Organization address address: Largo Agostino Gemelli 1 city: MILANO postcode: 20123 website: www.unicattolica.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (MILANO)	participant	88˙987.00
11	UNIWERSYTET MIKOLAJA KOPERNIKA W TORUNIU UNIWERSYTET MIKOLAJA KOPERNIKA W TORUNIU Organization address address: UL. JURIJA GAGARINA 11 city: TORUN postcode: 87100 website: http://www.umk.pl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	PL (TORUN)	participant	76˙290.00
12	EUROPEAN RESPIRATORY SOCIETY EUROPEAN RESPIRATORY SOCIETY Organization address address: AVENUE SAINTE LUCE 4 city: LAUSANNE postcode: 1003 website: www.ersnet.org contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (LAUSANNE)	participant	65˙750.00
13	UNIVERSITY OF TECHNOLOGY SYDNEY UNIVERSITY OF TECHNOLOGY SYDNEY Organization address address: BROADWAY BUILDING 1 ULTIMO NSW city: SYDNEY postcode: 2007 website: http://uts.edu.au/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AU (SYDNEY)	participant	0.00

Map

Project objective

The BETTER-B consortium tests whether mirtazapine, currently used as an antidepressant, is an effective treatment to reduce chronic or refractory breathlessness (CB) in patients with advanced chronic obstructive pulmonary or interstitial lung disease (COPD or ILD) needing palliative care or at the end of life.

Our focus is on breathlessness that persists despite optimal treatment of the underlying condition. This widespread and frightening symptom has a major detrimental impact on patients’ quality of life and distresses their family, friends and carers. It is associated with physical and psychosocial morbidity and results in high use of health care services, including emergency care.

There are no licenced medicines for CB in the world. It is a major challenge to clinical management, care quality and patient wellbeing. We have completed a feasibility trial in 60 patients, reviews and case studies that suggest mirtazapine is a promising treatment.

To assess if mirtazapine is effective, we conduct a randomised double blind clinical trial of mirtazapine versus placebo in patients with CB and COPD or ILD. The trial recruits 324 patients over 18 months across respiratory, palliative care and community services in Poland, Ireland, Italy, Germany and the UK. We study the effects of treatment over time on patients, their family or caregivers and care costs. We survey clinicians and produce accessible European guidance on treating CB.

The consortium unites a unique multi-disciplinary group of clinician scientists from respiratory, palliative, geriatric and rehabilitation fields, alongside statisticians, trialists, health economists, health care researchers, patient and consumer groups and a European Society. This ensures the optimal design and operation of the trial and the widest impact from its results.

Using an existing medicine for a different purpose offers a highly cost-effective approach for treatment that can be implemented and sustained internationally.

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The information about "BETTER-B" are provided by the European Opendata Portal: CORDIS opendata.

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