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IntegraBrain SIGNED

Integrated Implant Technology for Multi-modal Brain Interfaces

Total Cost €

EC-Contrib. €

Partnership

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IntegraBrain project word cloud

Explore the words cloud of the IntegraBrain project. It provides you a very rough idea of what is the project "IntegraBrain" about.

treatment vision systemic energy direct injury electricity clinic actuator rodents excitation network coordinate observe time clinical soft deploy modal bioelectronic reversible monitor interfaces catalyse laboratory writing replace integrabrain building palette implantable functional seizure human miniature drugs medicine peripheral technological modalities tissue first hope sensor machine leads thermal supports nervous central degeneration progress block disability treating synergistic light neuromodulation niches chronic therapeutic implant clinician organs sensors ink inks actuators soon

Project "IntegraBrain" data sheet

The following table provides information about the project.

Coordinator	THE UNIVERSITY OF SHEFFIELD Organization address address: FIRTH COURT WESTERN BANK city: SHEFFIELD postcode: S10 2TN website: www.shef.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Total cost	1˙496˙000 €
EC max contribution	1˙496˙000 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2018-STG
Funding Scheme	ERC-STG
Starting year	2019
Duration (year-month-day)	from 2019-01-01 to 2023-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	THE UNIVERSITY OF SHEFFIELD THE UNIVERSITY OF SHEFFIELD Organization address address: FIRTH COURT WESTERN BANK city: SHEFFIELD postcode: S10 2TN website: www.shef.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (SHEFFIELD)	coordinator	1˙400˙375.00
2	TECHNISCHE UNIVERSITAET DRESDEN TECHNISCHE UNIVERSITAET DRESDEN Organization address address: HELMHOLTZSTRASSE 10 city: DRESDEN postcode: 1069 website: http://www.tu-dresden.de/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (DRESDEN)	participant	95˙625.00

Map

Project objective

Bioelectronic medicine may soon replace systemic drugs for treating some chronic conditions. The clinician will implant a miniature laboratory to deliver and coordinate a multi-modal treatment program directly at the affected tissue. The technology to bring this vision to the clinic is not yet available. The IntegraBrain project will contribute by building an implantable network of sensors and actuators. Actuators will deploy electricity, light, drugs and thermal energy as modalities of the therapeutic program, while sensors will monitor its progress. A key technological advance will be a method for direct writing of the sensor-actuator network. To achieve this, we will develop a palette of functional inks where each ink supports one of the therapeutic modalities.

The technology has the potential to be tailored for applications in soft tissue organs, especially in the nervous system, where injury or degeneration can result in chronic disability. We will apply IntegraBrain technology in two niches of the nervous system in rodents. In the central nervous system, we will demonstrate seizure control by multi-modal neuromodulation. In the peripheral nervous system, we will demonstrate reversible block and excitation. For the first time, we will observe if multi-modal neuromodulation leads to synergistic effects on the nervous system.

With the IntegraBrain project, we hope to catalyse pre-clinical development of implantable human-machine interfaces for therapeutic applications.

Publications

List of publications.
year	authors and title	journal	last update
2019	Christoph Tondera, Teuku Fawzul Akbar, Alvin Kuriakose Thomas, Weilin Lin, Carsten Werner, Volker Busskamp, Yixin Zhang, Ivan R. Minev Highly Conductive, Stretchable, and Cellâ€Adhesive Hydrogel by Nanoclay Doping published pages: 1901406, ISSN: 1613-6810, DOI: 10.1002/smll.201901406	Small 15/27	2020-02-18

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The information about "INTEGRABRAIN" are provided by the European Opendata Portal: CORDIS opendata.