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DaPhNIs SIGNED

Role of the Maternal Gut Microbiota in Immune Activation at the Maternal-Foetal Interface: Impact on Preeclampsia and Offspring's Immune Development

Total Cost €

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EC-Contrib. €

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Partnership

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 DaPhNIs project word cloud

Explore the words cloud of the DaPhNIs project. It provides you a very rough idea of what is the project "DaPhNIs" about.

offspring    complementary    issue    urgent    maternal    pharmacologic    independence    captures    primary    women    laboratory    suited    transition    hypotheses    expertise    potentially    she    capability    patients    outcomes    host    health    world    science    recruited    intervention    scope    country    amenable    thought    immunologist    reside    ideally    cohort    home    tolerance    class    reliably    microbes    additional    morbidity    silvia    mucosal    scientific    tackle    zeitgeist    identification    rescigno    boundaries    oncology    foetal    hosting    predicted    researcher    prof    italy    responsibility    academic    biomarkers    create    actions    disseminated    public    social    kick    prime    skills    largely    audiences    nor    prevented    organ    placental    emerge    immune    relevance    enterprise    translational    dr    arising    formerly    independent    expert    usa    milan    implications    community    off    er    mortality    microbiota    giugliano    preeclampsia    mechanisms    pathogenesis    elusive    accomplished    immunity    molecular    interface    synergistic    incumbent    pregnancy    maria    pursuit   

Project "DaPhNIs" data sheet

The following table provides information about the project.

Coordinator
HUMANITAS MIRASOLE SPA 

Organization address
address: VIA MANZONI 56
city: ROZZANO (MI)
postcode: 20100
website: www.humanitas.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 168˙277 €
 EC max contribution 168˙277 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-SE
 Starting year 2019
 Duration (year-month-day) from 2019-07-16   to  2021-07-15

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    HUMANITAS MIRASOLE SPA IT (ROZZANO (MI)) coordinator 168˙277.00

Map

 Project objective

Preeclampsia is a leading cause of morbidity and mortality in pregnancy. Although the pathogenesis remains largely elusive, it is thought to reside in loss of immune-tolerance at the maternal-foetal interface. At present, preeclampsia can neither be reliably predicted nor prevented. Scope of this research project is to investigate how changes in microbiota during pregnancy impact immune responses at the maternal-foetal interface, and to determine the consequences on pregnancy outcomes as well as development of offspring’s immunity. Translational relevance of findings specifically to preeclampsia will be evaluated in a large cohort of patients, with implications potentially arising from the identification of novel biomarkers and of molecular mechanisms amenable to pharmacologic intervention. The Experienced Researcher (ER) of this study, Dr. Silvia Giugliano, is an accomplished immunologist with primary expertise in organ-specific immune responses to microbes. Formerly an independent academic researcher in the USA, she was recently recruited to work at the European Institute of Oncology (Milan, Italy) by Prof. Maria Rescigno, a world-class expert in the field of microbiota and mucosal immunity, specifically to advance the hosting laboratory’s expertise in placental immunity. There is an urgent call for actions aimed at improving women’s health, and it is incumbent on the scientific community to tackle this issue. Thus, the present proposal captures the current zeitgeist and social responsibility of Science. Complementary, prime expertise between the ER and host laboratory will create a synergistic enterprise, ideally suited to the pursuit of this ambitious research goal. Findings and hypotheses generated in this process will kick off additional, related projects, and will be disseminated beyond the boundaries of the scientific community and to public audiences. The ER will emerge with new skills, and the capability to transition to independence in her home country.

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The information about "DAPHNIS" are provided by the European Opendata Portal: CORDIS opendata.

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