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DaPhNIs SIGNED

Role of the Maternal Gut Microbiota in Immune Activation at the Maternal-Foetal Interface: Impact on Preeclampsia and Offspring's Immune Development

Total Cost €

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EC-Contrib. €

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Partnership

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 DaPhNIs project word cloud

Explore the words cloud of the DaPhNIs project. It provides you a very rough idea of what is the project "DaPhNIs" about.

identification    tackle    independent    reliably    translational    hosting    actions    accomplished    implications    cohort    prevented    captures    zeitgeist    women    arising    country    she    urgent    interface    synergistic    organ    relevance    biomarkers    scientific    scope    placental    complementary    foetal    immunity    laboratory    additional    disseminated    host    independence    public    usa    largely    rescigno    health    giugliano    boundaries    reside    mechanisms    emerge    immune    hypotheses    home    audiences    academic    elusive    primary    incumbent    pharmacologic    expert    class    mucosal    mortality    microbiota    amenable    social    immunologist    world    silvia    science    prime    outcomes    formerly    potentially    pursuit    recruited    microbes    milan    suited    skills    enterprise    morbidity    prof    expertise    pathogenesis    italy    dr    kick    transition    capability    create    ideally    offspring    off    maternal    nor    patients    researcher    er    tolerance    maria    pregnancy    preeclampsia    molecular    responsibility    oncology    intervention    predicted    community    thought    issue   

Project "DaPhNIs" data sheet

The following table provides information about the project.

Coordinator
HUMANITAS MIRASOLE SPA 

Organization address
address: VIA MANZONI 56
city: ROZZANO (MI)
postcode: 20100
website: www.humanitas.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 168˙277 €
 EC max contribution 168˙277 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-SE
 Starting year 2019
 Duration (year-month-day) from 2019-07-16   to  2021-07-15

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    HUMANITAS MIRASOLE SPA IT (ROZZANO (MI)) coordinator 168˙277.00

Map

 Project objective

Preeclampsia is a leading cause of morbidity and mortality in pregnancy. Although the pathogenesis remains largely elusive, it is thought to reside in loss of immune-tolerance at the maternal-foetal interface. At present, preeclampsia can neither be reliably predicted nor prevented. Scope of this research project is to investigate how changes in microbiota during pregnancy impact immune responses at the maternal-foetal interface, and to determine the consequences on pregnancy outcomes as well as development of offspring’s immunity. Translational relevance of findings specifically to preeclampsia will be evaluated in a large cohort of patients, with implications potentially arising from the identification of novel biomarkers and of molecular mechanisms amenable to pharmacologic intervention. The Experienced Researcher (ER) of this study, Dr. Silvia Giugliano, is an accomplished immunologist with primary expertise in organ-specific immune responses to microbes. Formerly an independent academic researcher in the USA, she was recently recruited to work at the European Institute of Oncology (Milan, Italy) by Prof. Maria Rescigno, a world-class expert in the field of microbiota and mucosal immunity, specifically to advance the hosting laboratory’s expertise in placental immunity. There is an urgent call for actions aimed at improving women’s health, and it is incumbent on the scientific community to tackle this issue. Thus, the present proposal captures the current zeitgeist and social responsibility of Science. Complementary, prime expertise between the ER and host laboratory will create a synergistic enterprise, ideally suited to the pursuit of this ambitious research goal. Findings and hypotheses generated in this process will kick off additional, related projects, and will be disseminated beyond the boundaries of the scientific community and to public audiences. The ER will emerge with new skills, and the capability to transition to independence in her home country.

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The information about "DAPHNIS" are provided by the European Opendata Portal: CORDIS opendata.

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