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MEFISTO SIGNED

MEFISTO - Meniscal functionalised scaffold to prevent knee Osteoarthritis onset after meniscectomy

Total Cost €

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EC-Contrib. €

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Partnership

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MEFISTO project word cloud

Explore the words cloud of the MEFISTO project. It provides you a very rough idea of what is the project "MEFISTO" about.

native act lies benefits innovation biologically burden predict social meniscus knee environment osteoarthritis unloading meniscal inflammation morbidity nanoparticles device scaffold metal personalized post interact sacrificing healthcare mechanical morphological economic articular receiving revascularization technological whilst micro solutions prosthesis profiling compartment reconstructive osteoarthritic patients capacity strategy complete risk population inner interventions mefisto drug bioactive undergone clear undergo surrounding clinical degeneration tissues leaving functionalization nanobiomaterials substitutes tissue reducing active peripheral treat preventing modulation prevent functionalized vital ing socio efficacy meniscectomy onset vascularized oa zone patient avascular younger strategies reflecting inflammatory resection regenerate modulate levels biodegradable joint epidemic

Project "MEFISTO" data sheet

The following table provides information about the project.

Coordinator	GEISTLICH BIOMATERIALS VERTRIEBSGESELLSCHAFT MBH Organization address address: SCHNEIDWEG 5 city: BADEN-BADEN postcode: 76534 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Germany [DE]
Total cost	5˙996˙590 €
EC max contribution	5˙996˙590 € (100%)
Programme	1. H2020-EU.2.1.3. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies - Advanced materials) 2. H2020-EU.2.1.2. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies – Nanotechnologies)
Code Call	H2020-NMBP-TR-IND-2018
Funding Scheme	RIA
Starting year	2019
Duration (year-month-day)	from 2019-04-01 to 2023-11-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	GEISTLICH BIOMATERIALS VERTRIEBSGESELLSCHAFT MBH GEISTLICH BIOMATERIALS VERTRIEBSGESELLSCHAFT MBH Organization address address: SCHNEIDWEG 5 city: BADEN-BADEN postcode: 76534 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (BADEN-BADEN)	coordinator	361˙250.00
2	ACTIVE IMPLANTS BV ACTIVE IMPLANTS BV Organization address address: ZIJLWEG 148B 0301, 3HG city: HAARLEM postcode: 2015 BJ website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (HAARLEM)	participant	852˙762.00
3	HUMANITAS UNIVERSITY HUMANITAS UNIVERSITY Organization address address: VIA RITA LEVI MONTALCINI SNC city: PIEVE EMANUELE postcode: 20090 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (PIEVE EMANUELE)	participant	847˙375.00
4	UNIVERSITAIR MEDISCH CENTRUM UTRECHT UNIVERSITAIR MEDISCH CENTRUM UTRECHT Organization address address: HEIDELBERGLAAN 100 city: UTRECHT postcode: 3584 CX website: www.umcutrecht.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (UTRECHT)	participant	559˙442.00
5	KLINIKUM DER UNIVERSITAET REGENSBURG KLINIKUM DER UNIVERSITAET REGENSBURG Organization address address: FRANS JOSEF STRAUSS ALLEE 11 city: REGENSBURG postcode: 93053 website: www-cgi.uni-regensburg.de/Klinik/Klinikum/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (REGENSBURG)	participant	543˙750.00
6	UNIVERSITEIT ANTWERPEN UNIVERSITEIT ANTWERPEN Organization address address: PRINSSTRAAT 13 city: ANTWERPEN postcode: 2000 website: www.ua.ac.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (ANTWERPEN)	participant	498˙562.00
7	UNIVERSIDAD DE SANTIAGO DE COMPOSTELA UNIVERSIDAD DE SANTIAGO DE COMPOSTELA Organization address address: COLEXIO DE SAN XEROME PRAZA DO OBRADOIRO S/N city: SANTIAGO DE COMPOSTELA postcode: 15782 website: http://www.usc.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (SANTIAGO DE COMPOSTELA)	participant	482˙197.00
8	CONSIGLIO NAZIONALE DELLE RICERCHE CONSIGLIO NAZIONALE DELLE RICERCHE Organization address address: PIAZZALE ALDO MORO 7 city: ROMA postcode: 185 website: www.cnr.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (ROMA)	participant	461˙875.00
9	TISSUE CLICK LTD TISSUE CLICK LTD Organization address address: 28 SYCAMORE CLOSE city: BRIGHTON postcode: BN2 6SJ website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (BRIGHTON)	participant	381˙250.00
10	SCIPROM SARL SCIPROM SARL Organization address address: RUE DU CENTRE 70 city: SAINT SULPICE postcode: 1025 website: http://www.sciprom.ch contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (SAINT SULPICE)	participant	290˙000.00
11	ORTHOKEY ITALIA SRL ORTHOKEY ITALIA SRL Organization address address: PIAZZA NAZIONI UNITE 15 city: CARRARA MS postcode: 54033 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (CARRARA MS)	participant	253˙125.00
12	AIM GMBH - ASSESSMENT IN MEDICINE RESEARCH AND CONSULTING AIM GMBH - ASSESSMENT IN MEDICINE RESEARCH AND CONSULTING Organization address address: MARIE CURIE STR. 8 city: LORRACH postcode: 79539 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (LORRACH)	participant	248˙125.00
13	ETABLISSEMENT FRANCAIS DU SANG ETABLISSEMENT FRANCAIS DU SANG Organization address address: AVENUE DU STADE DE FRANCE 20 city: LA PLAINE SAINT DENIS postcode: 93210 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (LA PLAINE SAINT DENIS)	participant	216˙875.00

Map

Project objective

MEFISTO will develop two novel solutions to treat meniscus loss as a strategy for preventing the onset of an epidemic of post-meniscectomy knee osteoarthritis (OA) in Europe. Morphological profiling will identify the population of patients who, after meniscal resection, are at higher risk of early compartment degeneration, providing a personalized approach for the patient. The two different reconstructive strategies are: i) a controlled vascularized bioactive biodegradable meniscal scaffold, which will regenerate the native meniscus. This strategy will address younger patients with early osteoarthritic changes. ii) a bioactive non-biodegradable meniscal prosthesis, which will act as a mechanical unloading device and a drug delivery system, with the capacity to modulate the inflammatory environment. This strategy will address patients with advanced OA. A socio-economic analysis of the efficacy of existing meniscal substitutes will complete the project. This analysis is of vital importance for the European healthcare system, as it will provide a clear understanding of the costs and benefits of current clinical practice and predict the impact of the two new interventions. The technological innovation lies in the development of biologically active functionalized nanobiomaterials that can interact with the surrounding articular tissues. The biodegradable scaffold will promote revascularization in the peripheral zone, while leaving the inner zone avascular, reflecting the native meniscal tissue and functionalization with drug delivery micro/nanoparticles of the non-biodegradable device will provide modulation of inflammation. The impact is expected to be significant as so many patients have undergone or will undergo meniscectomy. The interventions developed in MEFISTO will prevent these patients from receiving joint-sacrificing procedures such as metal prosthesis whilst reducing the social burden, associated costs and high levels of morbidity resulting from OA.

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The information about "MEFISTO" are provided by the European Opendata Portal: CORDIS opendata.

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