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GlyCANswer SIGNED

Decoding the Cancer Glycoproteome Driven Immune Response

Total Cost €

EC-Contrib. €

Partnership

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GlyCANswer project word cloud

Explore the words cloud of the GlyCANswer project. It provides you a very rough idea of what is the project "GlyCANswer" about.

regulation explore innovative therapeutic cancer majority cells glycomics mouse dictates cell undergone despite map glycoproteomics cutting immunotherapy unresectable formidable modern interplay edge continues biomarkers deaths culture glycan immunotherapeutics frequent benefit glycosylation predictive combination progress mediated elucidate immune breast advent immunomodulatory recognition models treatment exists mechanisms paradigm strategies glycanswer envisions shift predict lung biomarker profiling unravel medicine therapy patients glycoproteome worldwide malignancies

Project "GlyCANswer" data sheet

The following table provides information about the project.

Coordinator	INSTITUT FUER MOLEKULARE BIOTECHNOLOGIE GMBH Organization address address: DR BOHRGASSE 3 city: WIEN postcode: 1030 website: www.imba.oeaw.ac.at contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Austria [AT]
Total cost	174˙167 €
EC max contribution	174˙167 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2018
Funding Scheme	MSCA-IF-EF-SE
Starting year	2019
Duration (year-month-day)	from 2019-05-15 to 2021-05-14

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	INSTITUT FUER MOLEKULARE BIOTECHNOLOGIE GMBH INSTITUT FUER MOLEKULARE BIOTECHNOLOGIE GMBH Organization address address: DR BOHRGASSE 3 city: WIEN postcode: 1030 website: www.imba.oeaw.ac.at contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AT (WIEN)	coordinator	174˙167.00

Map

Project objective

Cancer continues to be the most formidable challenge in modern medicine and the second leading cause of deaths worldwide. However, in recent years, the treatment of unresectable cancer has undergone a paradigm shift with the advent of immunotherapy. Yet, despite the great progress in the field, the majority of cancer patients still do not respond to any of the available immunotherapeutics and no reliable biomarker exists to predict those patients that would benefit from it.

In order to facilitate the development of new strategies for immunotherapy, and to identify improved predictive biomarkers for treatment response, the GlyCANswer project envisions to elucidate how the cancer glycoproteome dictates the immune response. The GlyCANswer project aims to unravel the interplay between the cancer cell glycoproteome and immune recognition in the two most frequent malignancies worldwide, namely lung and breast cancer. By using a combination of cutting-edge glycoproteomics, glycomics and immune profiling approaches in innovative mouse models and cell culture systems, the GlyCANswer project will 1) map the immunomodulatory glycosylation of cancer cells 2) explore the detailed mechanisms of glycan-mediated immune regulation 3) identify new biomarkers and provide new therapeutic targets for immune therapy.

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The information about "GLYCANSWER" are provided by the European Opendata Portal: CORDIS opendata.