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LC-FMRI SIGNED

Deciphering the effects of locus coeruleus activity on whole-brain dynamics and neurovascular coupling

Total Cost €

EC-Contrib. €

Partnership

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LC-FMRI project word cloud

Explore the words cloud of the LC-FMRI project. It provides you a very rough idea of what is the project "LC-FMRI" about.

endpoint imaging brain clinical resonance imperative psychiatric performed neurons vital broad connections autonomous astrocytic groups behavior translation network calcium neural optical human simultaneous functional modulates lc fmri anesthesia mice vascular function coupling locus functions perform awake coeruleus dynamics regulates stimulation magnetic optogenetic circumvent sensory downstream comprehensively recordings confounding disease small lay neurovascular health reconfiguration effect neurodegenerative contributions experiments foundation cognitive ultra acquire gained disorders decipher context

Project "LC-FMRI" data sheet

The following table provides information about the project.

Coordinator	FUNDACAO D. ANNA SOMMER CHAMPALIMAUD E DR. CARLOS MONTEZ CHAMPALIMAUD Organization address address: AVENIDA BRASILIA, CENTRO DE INVESTIGACAO DA FUNDACAO CHAMPALIMAUD city: LISBOA postcode: 1400-038 website: http://fchampalimaud.org/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Portugal [PT]
Total cost	147˙815 €
EC max contribution	147˙815 € (100%)
Programme	1. H2020-EU.4. (SPREADING EXCELLENCE AND WIDENING PARTICIPATION)
Code Call	H2020-WF-01-2018
Funding Scheme	MSCA-IF-EF-ST
Starting year	2019
Duration (year-month-day)	from 2019-09-01 to 2021-08-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	FUNDACAO D. ANNA SOMMER CHAMPALIMAUD E DR. CARLOS MONTEZ CHAMPALIMAUD FUNDACAO D. ANNA SOMMER CHAMPALIMAUD E DR. CARLOS MONTEZ CHAMPALIMAUD Organization address address: AVENIDA BRASILIA, CENTRO DE INVESTIGACAO DA FUNDACAO CHAMPALIMAUD city: LISBOA postcode: 1400-038 website: http://fchampalimaud.org/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	PT (LISBOA)	coordinator	147˙815.00

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Project objective

Locus coeruleus (LC) regulates vital autonomous and cognitive functions and has recently gained interest as a clinical target in neurodegenerative and psychiatric disorders. Previous studies have investigated the effect of LC activity on small groups of neurons and on endpoint behavior. However, LC’s widespread connections and broad downstream effects make a systems-level approach imperative for comprehensively understanding LC function. In LC-FMRI, we will perform highly specific optogenetic LC stimulation in mice and assess whole-brain responses and functional network reconfiguration using ultra-high field functional magnetic resonance imaging (fMRI). To decipher neural, astrocytic and vascular contributions to LC-induced fMRI responses, we will acquire simultaneous optical calcium recordings during fMRI. Experiments will be performed in awake mice to circumvent confounding effects of anesthesia on LC function. Finally, we will investigate how LC stimulation affects whole-brain dynamics and neurovascular coupling in the context of sensory processing. Our project will lay the foundation for studying how LC modulates whole-brain dynamics in health and disease using fMRI, with high potential for translation to human applications.

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The information about "LC-FMRI" are provided by the European Opendata Portal: CORDIS opendata.