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EVOMORPHYS SIGNED

Identifying how Evolution exploits physical properties of tissues to generate the complexity and diversity of Life

Total Cost €

0

EC-Contrib. €

0

Partnership

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 EVOMORPHYS project word cloud

Explore the words cloud of the EVOMORPHYS project. It provides you a very rough idea of what is the project "EVOMORPHYS" about.

imaging    experiments    reaction    captures    latter    space    compute    pattern    species    numerical    layered    biological    model    ended    geometries    answering    constitute    alife    morphological    physical    migration    evolutionary    explores    first    algorithm    symmetry    coupling    effect    polymeric    scaleless    life    morphogenesis    patterns    simulations    multiple    crispr    darwinian    claim    evolution    laboratory    artificial    phenotypes    gels    mutants    my    modify    exploits    evomorphys    diffusion    mechanics    skin    fundamental    embryonic    correspondences    complexity    principles    combine    newtonian    3d    generating    interactions    configurations    mathematical    explored    generates    functional    morphologies    proliferation    cas9    cell    biology    generate    living    breaking    geometry    signalling    framework    models    forms    colour    question    silico    lizard    genetic    patterning    physics    squamate    performing    synthesis    events    diversity    systematically    extensive    drivers    explore   

Project "EVOMORPHYS" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITE DE GENEVE 

Organization address
address: RUE DU GENERAL DUFOUR 24
city: GENEVE
postcode: 1211
website: www.unige.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 2˙499˙070 €
 EC max contribution 2˙499˙070 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-ADG
 Funding Scheme ERC-ADG
 Starting year 2019
 Duration (year-month-day) from 2019-08-01   to  2024-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE DE GENEVE CH (GENEVE) coordinator 2˙499˙070.00

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 Project objective

My project focuses on answering one fundamental question: what are the drivers of Life’s morphological complexity and diversity? I claim that this question can only be addressed by a Newtonian-Darwinian synthesis that considers how Evolution exploits the physical properties of living matter. I will investigate how the evolutionary process explores the phase space of possible interactions between physical (mechanics, reaction-diffusion) and biological (cell signalling, proliferation, migration) processes and generates configurations that compute functional phenotypes. In particular, I will combine experiments in biology and physics, as well as mathematical models and Artificial-Life (ALife) numerical simulations. The latter will be based on physics’ first principles, symmetry-breaking processes and a genetic algorithm. First, I will investigate how geometry affects signalling by (i) imaging the embryonic development of colour patterns and skin geometries of multiple squamate species with various scale-to-colour pattern correspondences, (ii) generating CRISPR/Cas9 scaleless mutants in two lizard species to study the effect of skin 3D geometry on colour patterning, and (iii) performing ALife experiments to explore how the evolutionary process can modify signalling events and exploit geometry to generate new patterns. Second, I will analyse how growth can affect geometry by (i) performing in-silico experiments where coupling between growth and morphogenesis is systematically explored and (ii) evaluating how much the in-silico model captures morphologies generated with physics laboratory experiments using 3D layered polymeric gels. Third, I will build a Newtonian-Darwinian framework by coupling geometry, signalling, growth and mechanics in extensive open-ended ALife experiments. The results of the EVOMORPHYS project will constitute a novel framework for understanding how Evolution exploits physics to generate the morphological diversity and complexity of Life forms.

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The information about "EVOMORPHYS" are provided by the European Opendata Portal: CORDIS opendata.

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