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DNA-DOCK SIGNED

Precision Docking of Very Large DNA Cargos in Mammalian Genomes

Total Cost €

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EC-Contrib. €

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Partnership

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 DNA-DOCK project word cloud

Explore the words cloud of the DNA-DOCK project. It provides you a very rough idea of what is the project "DNA-DOCK" about.

provides    vitro    accelerate    sites    goals    generally    virus    gene    integration    genomic    code    crispr    generate    transduction    techniques    fine    utilize    parallelized    applicable    capability    representing    ease    bottleneck    human    safe    once    efficiency    catalysing    genomes    cargos    revolution    array    precision    producing    complemented    resolving    capacities    edits    resolve    dna    multicomponent    genes    largely    remained    designer    breaking    synthesis    exceptionally    local    vital    genome    small    unlock    circuitry    insert    unparalleled    affordable    programmable    flexible    base    edit    rational    assembly    equal    carry    communities    date    interface    disrupt    worldwide    multifunctional    breath    broad    industrial    biomedical    technologies    pairs    rewrite    cell    pair    unprecedented    synthetic    evolution    speed    functions    capacity    aspire    sophisticated    nanodevices    ground    tools    medical    scientific    mammalian    insertions    darwinian    functionalities    unmet    cas9    circuits    editing    tool    unmatched    thousands    docking    rewarding    full    unaddressed    tuneable    engineering   

Project "DNA-DOCK" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY OF BRISTOL 

Organization address
address: BEACON HOUSE QUEENS ROAD
city: BRISTOL
postcode: BS8 1QU
website: www.bristol.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 2˙498˙578 €
 EC max contribution 2˙498˙578 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-ADG
 Funding Scheme ERC-ADG
 Starting year 2019
 Duration (year-month-day) from 2019-09-01   to  2024-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF BRISTOL UK (BRISTOL) coordinator 2˙498˙578.00

Map

 Project objective

Gene editing has developed at breath-taking speed. In particular CRISPR/Cas9 provides a tool-set thousands of researchers worldwide now utilize with unprecedented ease to edit genes, catalysing a broad range of biomedical and industrial applications. Gene synthesis technologies producing thousands of base pairs of synthetic DNA have become affordable. Current gene editing technology is highly effective for local, small genomic DNA edits and insertions. To unlock the full potential of this revolution, however, our capacities to disrupt or rewrite small local elements of code must be complemented by equal capacities to efficiently insert very large synthetic DNA cargos with a wide range of functions into genomic sites. Large designer cargos would carry multicomponent DNA circuitry including programmable and fine-tuneable functionalities, representing the vital interface between gene editing which is the state-of-the-art at present, and genome engineering, which is the future. This challenge remained largely unaddressed to date.

We aspire to resolve this bottleneck by creating ground-breaking, generally applicable, easy-to-use technology to enable docking of large DNA cargos with base pair precision and unparalleled efficiency into mammalian genomes. To achieve our ambitious goals, we will apply a whole array of sophisticated tools. We will unlock a small non-human virus to rational design, creating safe, flexible and easy-to-produce, large capacity DNA delivery nanodevices with unmatched transduction capability. We will exploit a range of techniques including Darwinian in vitro selection/evolution to accomplish unprecedented precision DNA integration efficiency into genomic sites. We will use parallelized DNA assembly methods to generate multifunctional circuits, to accelerate T cell engineering, resolving unmet needs. Once we accomplish our tasks, our technology has the potential to be exceptionally rewarding to the scientific, industrial and medical communities.

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The information about "DNA-DOCK" are provided by the European Opendata Portal: CORDIS opendata.

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