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AND-PD SIGNED

COMORBIDITY MECHANISMS OF ANXIETY AND PARKINSON’S DISEASE

Total Cost €

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EC-Contrib. €

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Partnership

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AND-PD project word cloud

Explore the words cloud of the AND-PD project. It provides you a very rough idea of what is the project "AND-PD" about.

molecular morbid link diagnosis genetic counteract neurotransmission brain patients central phenotype prove dysfunction mechanisms selectively rodent databases causative mental human fmri striatal beneficiaries caused behavioural secondary circuits rna imaging assignment encoding anatomical interventions causality markers gap cells preclinical nucleus co neuropathology correlate morbidity dopamine microcircuit function bridge damage neurotoxin dopaminergic degeneration signs drn underlie valence clinical translational experiments pet serotonergic pd cohort biobank models retrospective samples regions dysfunctional comorbidities patient morbidities primate emotional reproduce pathological motor neurons investigates treatment aberrant dorsal hypothesis depression posits causalities anxiety biomarkers physiological alter inform raphe functional

Project "AND-PD" data sheet

The following table provides information about the project.

Coordinator	AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS Organization address address: CALLE SERRANO 117 city: MADRID postcode: 28006 website: http://www.csic.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Spain [ES]
Total cost	5˙995˙848 €
EC max contribution	5˙995˙848 € (100%)
Programme	1. H2020-EU.3.1.1. (Understanding health, wellbeing and disease)
Code Call	H2020-SC1-2019-Two-Stage-RTD
Funding Scheme	RIA
Starting year	2020
Duration (year-month-day)	from 2020-01-01 to 2023-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS Organization address address: CALLE SERRANO 117 city: MADRID postcode: 28006 website: http://www.csic.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (MADRID)	coordinator	630˙906.00
2	KAROLINSKA INSTITUTET KAROLINSKA INSTITUTET Organization address address: Nobels Vag 5 city: STOCKHOLM postcode: 17177 website: www.ki.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (STOCKHOLM)	participant	1˙058˙867.00
3	FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA Organization address address: VIA MOREGO 30 city: GENOVA postcode: 16163 website: www.iit.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (GENOVA)	participant	820˙976.00
4	KING'S COLLEGE LONDON KING'S COLLEGE LONDON Organization address address: STRAND city: LONDON postcode: WC2R 2LS website: www.kcl.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	participant	748˙286.00
5	Motac France Motac France Organization address address: 30 avenue des mondaults city: Floirac postcode: 33270 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (Floirac)	participant	690˙735.00
6	THE HEBREW UNIVERSITY OF JERUSALEM THE HEBREW UNIVERSITY OF JERUSALEM Organization address address: EDMOND J SAFRA CAMPUS GIVAT RAM city: JERUSALEM postcode: 91904 website: www.huji.ac.il contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IL (JERUSALEM)	participant	531˙372.00
7	UNIVERSITE DE BORDEAUX UNIVERSITE DE BORDEAUX Organization address address: PLACE PEY BERLAND 35 city: BORDEAUX postcode: 33000 website: www.nouvelle-univ-bordeaux.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (BORDEAUX)	participant	531˙250.00
8	UNIVERSITY COLLEGE LONDON UNIVERSITY COLLEGE LONDON Organization address address: GOWER STREET city: LONDON postcode: WC1E 6BT website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	participant	448˙984.00
9	TRANSINE THERAPEUTICS LIMITED TRANSINE THERAPEUTICS LIMITED Organization address address: 1 MIDDLE DRIFT city: ROYSTON postcode: SG8 5BU website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (ROYSTON)	participant	250˙000.00
10	MODUS RESEARCH AND INNOVATION LIMITED MODUS RESEARCH AND INNOVATION LIMITED Organization address address: 7-11 MELVILLE STREET city: EDINBURGH postcode: EH3 7PE website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (EDINBURGH)	participant	153˙845.00
11	FUNDACION PARA LA INVESTIGACION MEDICA APLICADA FIMA FUNDACION PARA LA INVESTIGACION MEDICA APLICADA FIMA Organization address address: AVENIDA DE PIO XII 55 city: PAMPLONA postcode: 31008 website: www.cima.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (PAMPLONA)	participant	130˙625.00

Map

Project objective

AND-PD investigates causative mechanisms of anxiety (with or without depression) as a non-motor co-morbidity of PD. The central hypothesis posits that degeneration of dopaminergic neurons in the dorsal raphe nucleus (DRN) affects the activity of serotonergic cells which could alter DRN microcircuit and neurotransmission to target brain regions encoding for emotional valence. Dysfunction of DRN circuits and aberrant assignment of emotional valence, secondary to dopamine loss in the DRN of PD patients, may underlie PD-related anxiety. Using models of mental comorbidities of PD, AND-PD will investigate functional changes in the DRN-striatal circuits and establish the link between anxiety phenotype and degeneration of dopaminergic neurons in the DRN. Findings will be used to inform pre-clinical (rodent, non-human primate and biobank samples) and clinical research (fMRI and PET imaging, behavioural analysis, retrospective cohort analysis) to identify and correlate causalities between dysfunctional DRN activity and co-morbid anxiety of PD. To prove causality, AND-PD will i) analyse anxiety in neurotoxin and genetic models of PD; ii) assess the physiological impact and behavioural effects of interventions that selectively reproduce the damage caused by PD in the DRN; and iii) determine the ability of RNA based approaches targeting the DRN to counteract anxiety associated with PD. To demonstrate the link in human patients, AND-PD will analyse patient databases and correlate measures of anxiety with: 1) signs of neuropathology in PD brain samples’ DRN and 2) clinical and functional biomarkers of dopamine and serotonergic function through DRN imaging in patients. AND-PD beneficiaries’ experience in translational research will help ‘bridge the gap’ between preclinical and clinical experiments and help identify new anatomical targets and markers (molecular, functional and pathological,) to support better diagnosis, management and treatment of co-morbidities in PD patients.

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