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mARs SIGNED

mARs: Mobile DNA driven antibiotic resistance spreading: molecular strategies, control and evolution for broad distribution

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 mARs project word cloud

Explore the words cloud of the mARs project. It provides you a very rough idea of what is the project "mARs" about.

situ    implications    mechanisms    occurs    mobile    resistant    chart    preventive    ar    antibiotic    spreading    gene    elucidate    promotes    multidrug    drugs    humans    transposons    molecular    communities    interaction    interplay    era    last    structure    biology    spread    draw    drive    pathogens    broad    carriers    microbiology    genes    dissect    determinants    diversity    bacterial    genetics    prevalence    intervention    resistance    virulent    reducing    gut    microbial    regulation    mechanistic    model    bioinformatic    movies    significance    health    functional    gained    underlying    annotated    reveal    promiscuous    superbugs    data    view    unclear    functionally    integrons    disciplines    sparse    meta    vitro    machineries    limited    evolution    clinical    hotspots    protein    bacteria    confer    natural    bridging    combining    biochemical    quests    drug    movement    environments    cells    dna    biochemistry    structural    resort    insights    genomic    bioinformatics    transfer    care    rare    strategies   

Project "mARs" data sheet

The following table provides information about the project.

Coordinator
EUROPEAN MOLECULAR BIOLOGY LABORATORY 

Organization address
address: Meyerhofstrasse 1
city: HEIDELBERG
postcode: 69117
website: http://www.embl.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙999˙118 €
 EC max contribution 1˙999˙118 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-COG
 Funding Scheme ERC-COG
 Starting year 2021
 Duration (year-month-day) from 2021-01-01   to  2025-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    EUROPEAN MOLECULAR BIOLOGY LABORATORY DE (HEIDELBERG) coordinator 1˙999˙118.00

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 Project objective

Antibiotic resistance (AR) is spreading rapidly, leading to the development of highly virulent pathogens and multidrug-resistant ‘superbugs’, a major health concern of our era. Mobile DNA elements, transposons and integrons, effectively drive the spread of AR genes in microbial interaction hotspots, such as bacterial communities in humans and natural environments. Yet, our knowledge of their mechanisms remains very sparse. It is unclear how DNA movement occurs on the molecular level and how it is controlled in cells and communities; biochemical and structural data are rare and our view on their diversity and evolution is limited. Here I propose an integrated approach combining bioinformatics, genetics, microbiology, biochemistry, and structural biology to elucidate the mechanisms and diversity of mobile DNA driven resistance spreading. I want to (a) investigate the molecular mechanisms and regulation of AR gene movement in vitro, in model bacteria and in gut bacterial communities; (b) dissect the structure of the underlying molecular machineries to reveal how protein-DNA interplay promotes gene transfer; and (c) characterize the diversity, evolution and functional success of distinct molecular pathways. Mechanistic work will focus on selected mobile elements that confer resistance to last resort drugs and promiscuous gene carriers with high prevalence in health care. Bioinformatic quests will draw on recent (meta)genomic data to chart the clinical significance of molecular insights in situ. By bridging disciplines, I want to provide functionally annotated molecular movies of gene movement and explain how specific molecular strategies evolved to enable broad dissemination of resistance determinants. The insights gained in this research will provide in-depth knowledge on major AR transfer pathways and will have key implications for the development of novel intervention strategies and preventive measures aimed at reducing dissemination of drug resistance in bacteria.

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