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Kidney-Treg SIGNED
Characterisation and impact of kidney-resident Tregs in kidney physiology and pathologies
Total Cost €
0EC-Contrib. €
0Partnership
0Views
0Kidney-Treg project word cloud
Explore the words cloud of the Kidney-Treg project. It provides you a very rough idea of what is the project "Kidney-Treg" about.
tregs
impacts
expansion
tools
subtype
tolerance
skills
located
career
me
mapping
resident
innovative
physiology
constitute
laboratory
cell
molecular
repair
expand
therapies
functionally
effect
models
promotion
circulation
give
biology
supplementation
techniques
immunosuppressive
therapeutic
critical
induction
autoimmunity
diseases
personal
tissue
academia
treg
transplantation
inducing
pursue
unknown
gained
uniquely
harnessing
injury
exerting
photoactivatable
depletion
mouse
scrnaseq
model
scientific
cells
feasible
cre
alternative
population
systemic
kidney
distinction
manipulation
impacting
resides
first
immune
fate
phenotypically
characterise
nature
functions
host
recombinase
protection
vital
exploring
prevent
pathologies
combined
highlighting
suppression
Project "Kidney-Treg" data sheet
The following table provides information about the project.
| Coordinator |
THE BABRAHAM INSTITUTE
Organization address contact info |
| Coordinator Country | United Kingdom [UK] |
| Total cost | 224˙933 € |
| EC max contribution | 224˙933 € (100%) |
| Programme |
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility) |
| Code Call | H2020-MSCA-IF-2019 |
| Funding Scheme | MSCA-IF-EF-ST |
| Starting year | 2020 |
| Duration (year-month-day) | from 2020-04-01 to 2022-03-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | THE BABRAHAM INSTITUTE | UK (CAMBRIDGE) | coordinator | 224˙933.00 |
Map
Project objective
Tregs are a subtype of T cells exerting immunosuppressive functions that are vital to prevent autoimmunity. Recently, tissue-resident Tregs have been proposed to be phenotypically and functionally distinct from the generic Tregs in circulation. Systemic Treg supplementation and depletion studies strongly support a role for Tregs in protection from injury and promotion of tissue repair in models of kidney diseases, highlighting the potential of harnessing Tregs in these pathologies. However, due to the systemic nature of the Treg manipulation in these studies, it is unknown if the effect resides in systemic impacts or in tissue-based impacts. The aim of this project is to characterise Tregs located in the kidney and to expand the kidney-resident Treg population, without impacting the systemic population, in order to evaluate their specific impact on the physiology and pathologies of the kidney. First, I will characterise the kidney-resident Tregs using state-of-the-art molecular biology techniques, such as scRNAseq, and an innovative mouse model of cell fate mapping based on a photoactivatable Cre-recombinase. Second, I will evaluate their specific functions in physiology and pathologies of the kidney using a mouse model of tissue-specific Treg expansion uniquely available in the host laboratory. As well as the novel biology exploring the potential functions of kidney-resident Tregs, the distinction between systemic and kidney-based effects is critical to develop new therapeutic tools aiming to target kidney-resident Tregs. The induction of tissue-specific tolerance for kidney autoimmunity or transplantation, without inducing systemic immune suppression, constitute a promising and feasible alternative to existing immunosuppressive therapies. The knowledge and experience gained from this project combined with my scientific and personal development will give me all the skills I need to achieve my objective to pursue an exciting scientific career in academia.
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The information about "KIDNEY-TREG" are provided by the European Opendata Portal: CORDIS opendata.
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