Opendata, web and dolomites
OMIT SIGNED
The role of microbial Oxylipins in the MIcrobe-hosT dialogue
Total Cost €
0EC-Contrib. €
0Partnership
0Views
0OMIT project word cloud
Explore the words cloud of the OMIT project. It provides you a very rough idea of what is the project "OMIT" about.
microbial
bacteria
waters
latter
comprising
reactions
perceived
characterised
training
platforms
spectrometry
regulators
competencies
gene
oxylipins
quality
implicit
proliferation
mechanistic
dialogue
chromatography
crohns
acids
microbe
liquid
liberated
migration
healthy
function
expression
continue
diversity
microbially
interactions
additional
scientific
add
supernatants
analysed
validated
biobanked
gained
biofilm
precursor
oxidation
chemical
she
man
omit
receive
examine
faecal
functions
maturity
eicosanoids
samples
patients
mass
discovery
platform
ultra
docosanoids
microbiome
contributions
volunteers
profiling
human
economy
oxlipin
hoxy
cell
chemotaxis
contribution
building
msca
leadership
humans
secondment
performed
experiments
fatty
appreciated
vitro
octadecanoids
disease
assays
biochemical
signalling
host
signals
career
performance
bacterial
independent
co
line
headquarters
inflammation
immune
incubation
roles
professional
society
moxy
fellowships
health
uk
significantly
culture
oxylipin
ms
Project "OMIT" data sheet
The following table provides information about the project.
| Coordinator |
UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK
Organization address contact info |
| Coordinator Country | Ireland [IE] |
| Total cost | 196˙590 € |
| EC max contribution | 196˙590 € (100%) |
| Programme |
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility) |
| Code Call | H2020-MSCA-IF-2019 |
| Funding Scheme | MSCA-IF-EF-RI |
| Starting year | 2020 |
| Duration (year-month-day) | from 2020-11-09 to 2022-11-08 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK | IE (Cork) | coordinator | 196˙590.00 |
Map
Project objective
OMIT aims to examine the role of microbial Oxylipins in the MIcrobiome:hosT dialogue. Oxylipins liberated from the oxidation of fatty acids are appreciated as key chemical signals perceived by both microbe and man. Human oxylipins (hOXY), comprising eicosanoids, docosanoids and octadecanoids are well characterised; they are implicit in many biochemical and signalling pathways in humans, including cell migration, proliferation, chemotaxis, immune reactions and most importantly, they are key regulators of inflammation. However, the diversity, functions, impact and mechanistic roles of microbially derived oxylipins (mOXY) are not well understood. State-of-the-art ultra-performance liquid chromatography-mass spectrometry (MS) platforms (secondment at Waters MS Headquarters, UK) will be developed and validated for oxylipin analysis in faecal samples and bacterial supernatants derived from co-incubation experiments (i.e. bacteria and oxlipin precursor). The latter will facilitate the discovery of novel mOXY. Additional bacterial biofilm assays will be performed to examine the role of mOXY in microbe-microbe interactions. To determine the contribution of mOXY in health and disease, biobanked samples from healthy volunteers and Crohns disease patients will be analysed. In vitro cell culture experiments and gene expression profiling will determine the function of mOXY in microbe-host interactions. During this project, the applicant will receive high quality training through research that will significantly improve scientific knowledge and provide a strong platform for building an independent research career. In line with the Work Programme for the MSCA fellowships, the knowledge and competencies gained by the applicant will add to developing her potential to achieve professional maturity and leadership in the field so that she may continue to make significant contributions to society and the economy.
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The information about "OMIT" are provided by the European Opendata Portal: CORDIS opendata.
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No valid XML
lastchecktime (2024-05-11 12:20:25) correctly updated