Opendata, web and dolomites
MiMoZa SIGNED
Microbiota modulation through horizontal gene transfer.
Total Cost €
0EC-Contrib. €
0Partnership
0Views
0MiMoZa project word cloud
Explore the words cloud of the MiMoZa project. It provides you a very rough idea of what is the project "MiMoZa" about.
transgenes
agricultural
my
prokaryotes
material
competition
infection
immune
abundances
human
influencing
despite
microbes
ways
hgt
gene
horizontal
strain
cocktails
alternative
ilana
led
brito
stay
functions
lab
metagenomic
probiotic
bodies
rates
possibilities
resident
modulation
experimentally
nor
genetic
gut
selective
tract
fellowship
transfer
intimately
transfers
successful
realization
stimulate
jeroen
transit
microbiota
sizes
animal
dna
lifestyle
gm
msca
composition
difficile
health
limit
exchange
function
policies
residing
contacted
small
intestinal
natural
little
environments
initial
host
datasets
successes
modulate
gastro
connected
altering
relative
fecal
strategies
engraftment
treatment
pressure
antibiotic
changing
additional
effect
implications
examine
difficult
dietary
serve
species
microbiome
raes
myriad
time
medication
diet
spread
Project "MiMoZa" data sheet
The following table provides information about the project.
| Coordinator |
VIB
Organization address contact info |
| Coordinator Country | Belgium [BE] |
| Total cost | 266˙425 € |
| EC max contribution | 266˙425 € (100%) |
| Programme |
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility) |
| Code Call | H2020-MSCA-IF-2019 |
| Funding Scheme | MSCA-IF-GF |
| Starting year | 2020 |
| Duration (year-month-day) | from 2020-08-01 to 2023-07-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | VIB | BE (ZWIJNAARDE - GENT) | coordinator | 266˙425.00 |
| 2 | CORNELL UNIVERSITY | US (ITHACA NY) | partner | 0.00 |
Map
Project objective
My goal is to determine horizontal gene transfer (HGT) rates of specific functions within the gut microbiome. The microbes on and within our bodies, especially within our gastro-intestinal tract, are intimately connected with our immune system and promote health in myriad ways. Altering our gut microbiota (GM) composition and/or function might thus improve health. My research in the Jeroen Raes lab led to the realization that changing species abundances through dietary or lifestyle modulation may be difficult because of the small effect sizes of the factors influencing GM composition (e.g. diet, medication, or transit time). In addition, host-selection and competition of resident microbes, might limit the strain engraftment necessary for the effect of fecal transfers and probiotic cocktails. Despite initial successes (e.g. C. difficile infection treatment), current modulation strategies might therefore be less successful with other conditions. I contacted Ilana Brito, in order to find out whether HGT - a process in which prokaryotes exchange genetic material - may serve as an alternative way to modulate the residing GM. Little is known about the features that affect HGT rates within natural environments nor the role of selection in that process. If these were well-understood, it would allow to assess the possibilities of extending the gut microbiome with additional functions. During my research stay, I will experimentally determine HGT rates within the animal gut under natural and HGT-enhancing conditions. In addition, I will develop methods to examine HGT in metagenomic datasets and determine the relative importance of the factors influencing HGT (selective pressure, host health and DNA delivery method). The knowledge generated through this MSCA-fellowship will stimulate the development of novel GM modulation strategies and will have important implications for human health and agricultural policies (e.g. antibiotic use, spread of transgenes).
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The information about "MIMOZA" are provided by the European Opendata Portal: CORDIS opendata.
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