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SIGNAL SIGNED

Sensing Neuro-immune Activation in the Lung microenvironment

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 SIGNAL project word cloud

Explore the words cloud of the SIGNAL project. It provides you a very rough idea of what is the project "SIGNAL" about.

modulation    cues    multidisciplinary    neurons    compartmentalization    superficial    specialization    immune    lung    models    plays    chemogenetics    coordinators    lymphoid    ignore    immunity    pivotal    single    defense    disorders    signal    asthma    forming    neutrophils    microenvironmental    neuropeptides    neural    tolerance    signals    entirely    connections    suggest    power    function    specialized    influence    neuro    myself    elucidate    comprehensiveness    combining    ilc    integrating    vivo    resident    dendritic    homeostasis    obstructive    allergy    context    stromal    lack    networks    potentially    neuroimmune    curb    discovering    act    mouse    genomics    treating    discover    infections    detection    sentinel    unbiased    interactions    tissue    innate    bridging    adaptive    precision    gain    reactions    setup    selectiveness    linked    unknown    antigen    shown    cell    chronic    detect    neurological    tissues    indispensable    optogenetics    translate    nsilc    responsible    cells   

Project "SIGNAL" data sheet

The following table provides information about the project.

Coordinator
UNITED KINGDOM RESEARCH AND INNOVATION 

Organization address
address: POLARIS HOUSE NORTH STAR AVENUE
city: SWINDON
postcode: SN2 1FL
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 224˙933 €
 EC max contribution 224˙933 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2019
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2020
 Duration (year-month-day) from 2020-04-01   to  2022-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNITED KINGDOM RESEARCH AND INNOVATION UK (SWINDON) coordinator 224˙933.00

Map

 Project objective

The immune system is indispensable for our defense against infections, and plays an essential role in homeostasis, where compartmentalization and specialization are key aspects of every immune cell. Microenvironmental cues (e.g. stromal cell-derived signals) are integrated by the cell networks forming the immune system to maintain immune tolerance or promote immunity against an antigen. Recent findings suggest that neurons also contribute to curb the immune response; they produce neuropeptides that act directly on immune cells such as dendritic cells and neutrophils. However, our understanding of neuroimmune interactions is superficial: we ignore whether specialized cell subsets are responsible for integrating neural cues, we lack precision when studying these connections, and it is unknown whether neuroimmune exchanges are relevant in different tissues and immune reactions, as with the case of lung immune responses related to allergy and chronic obstructive disorders. Asthma has been shown to present a neurological component not yet entirely linked to the immune system. To gain insight into neuroimmune modulation, SIGNAL aims to elucidate the presence and function of neuro-sentinel innate lymphoid cells (nsILC) in the lung: ILC dedicated to detect and translate neuro-derived signals. ILC are tissue resident immune cells which are pivotal coordinators of immune homeostasis, bridging the innate and the adaptive immune system. Using a multidisciplinary approach by combining the selectiveness of optogenetics and chemogenetics with the unbiased power of detection of single cell genomics, and the comprehensiveness of mouse in vivo models, I have setup myself to discover and define nsILC in the context of type-2 responses in the lung. My work will develop our understanding of neuroimmune interactions, and their influence in allergy and asthma, potentially discovering pathways which will provide the context for new approaches in treating this type of disorders.

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The information about "SIGNAL" are provided by the European Opendata Portal: CORDIS opendata.

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