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Injectable anisotropic microgel-in-hydrogel matrices for spinal cord repair

Total Cost €


EC-Contrib. €






 ANISOGEL project word cloud

Explore the words cloud of the ANISOGEL project. It provides you a very rough idea of what is the project "ANISOGEL" about.

unidirectional    signaling    scaffold    subsequently    behavior    functional    polymerization    microheterogeneous    succesful    equipped    situ    encounter    group    healing    poly    rat    technique    physiological    architectures    organization    repair    forms    engineer    ratio    organs    clinical    fraction    hydrogel    cells    breakthrough    regeneration    volume    barrel    superparamagnetic    function    effect    muscles    create    ethylene    microgels    self    pathological    nanoparticles    nerves    matrix    macroscopic    cell    extracellular    bio    minimal    mechanical    generation    biomaterial    master    anisotropy    glycol    orientation    prepared    dimensions    decisive    mold    magnetic    local    structure    fabrication    hydrogels    matrices    microgel    tissues    directional    alignment    shape    vivo    crosslinking    lack    injury    animal    assemble    vitro    optimize    invasive    cord    realize    interlocked    structural    biomimetic    experiments    injectable    spinal    density    composites    mimic    tissue    anisotropic    injected    biological    fabricated    oriented   

Project "ANISOGEL" data sheet

The following table provides information about the project.


Organization address
city: AACHEN
postcode: 52074

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website
 Total cost 1˙435˙396 €
 EC max contribution 1˙435˙396 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-STG
 Funding Scheme ERC-STG
 Starting year 2015
 Duration (year-month-day) from 2015-03-01   to  2021-02-28


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

This project will engineer an injectable biomaterial that forms an anisotropic microheterogeneous structure in vivo. Injectable hydrogels enable a minimal invasive in situ generation of matrices for the regeneration of tissues and organs, but currently lack structural organization and unidirectional orientation. The anisotropic, injectable hydrogels to be developed will mimic local extracellular matrix architectures that cells encounter in complex tissues (e.g. nerves, muscles). This project aims for the development of a biomimetic scaffold for spinal cord regeneration. To realize such a major breakthrough, my group will focus on three research objectives. i) Poly(ethylene glycol) microgel-in-hydrogel matrices will be fabricated with the ability to create macroscopic order due to microgel shape anisotropy and magnetic alignment. Barrel-like microgels will be prepared using an in-mold polymerization technique. Their ability to self-assemble will be investigated in function of their dimensions, aspect ratio, crosslinking density, and volume fraction. Superparamagnetic nanoparticles will be included into the microgels to enable unidirectional orientation by means of a magnetic field. Subsequently, the oriented microgels will be interlocked within a master hydrogel. ii) The microgel-in-hydrogel matrices will be equipped with (bio)functional properties for spinal cord regeneration, i.e., to control and optimize mechanical anisotropy and biological signaling by in vitro cell growth experiments. iii) Selected hydrogel composites will be injected after rat spinal cord injury and directional tissue growth and animal functional behavior will be analyzed. Succesful fabrication of the proposed microgel-in-hydrogel matrix will provide a new type of biomaterial, which enables investigating the effect of an anisotropic structure on physiological and pathological processes in vivo. This is a decisive step towards creating a clinical healing matrix for anisotropic tissue repair.


year authors and title journal last update
List of publications.
2017 Abdolrahman Omidinia-Anarkoli, Sarah Boesveld, Urandelger Tuvshindorj, Jonas C. Rose, Tamás Haraszti, Laura De Laporte
An Injectable Hybrid Hydrogel with Oriented Short Fibers Induces Unidirectional Growth of Functional Nerve Cells
published pages: 1702207, ISSN: 1613-6810, DOI: 10.1002/smll.201702207
Small 13/36 2020-01-24
2018 Jonas C. Rose, Laura De Laporte
Hierarchical Design of Tissue Regenerative Constructs
published pages: 1701067, ISSN: 2192-2640, DOI: 10.1002/adhm.201701067
Advanced Healthcare Materials 2020-01-24
2017 Jonas C. Rose, María Cámara-Torres, Khosrow Rahimi, Jens Köhler, Martin Möller, Laura De Laporte
Nerve Cells Decide to Orient inside an Injectable Hydrogel with Minimal Structural Guidance
published pages: 3782-3791, ISSN: 1530-6984, DOI: 10.1021/acs.nanolett.7b01123
Nano Letters 17/6 2020-01-24
2018 Jonas C. Rose, David B. Gehlen, Tamás Haraszti, Jens Köhler, Christopher J. Licht, Laura De Laporte
Biofunctionalized aligned microgels provide 3D cell guidance to mimic complex tissue matrices
published pages: 128-141, ISSN: 0142-9612, DOI: 10.1016/j.biomaterials.2018.02.001
Biomaterials 163 2020-01-24

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