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ANISOGEL SIGNED

Injectable anisotropic microgel-in-hydrogel matrices for spinal cord repair

Total Cost €

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EC-Contrib. €

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Partnership

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 ANISOGEL project word cloud

Explore the words cloud of the ANISOGEL project. It provides you a very rough idea of what is the project "ANISOGEL" about.

cell    encounter    biological    muscles    architectures    matrices    animal    nerves    prepared    fabricated    biomimetic    alignment    oriented    magnetic    directional    poly    vivo    nanoparticles    unidirectional    lack    breakthrough    anisotropy    extracellular    equipped    regeneration    generation    mechanical    create    anisotropic    master    subsequently    fabrication    mold    forms    local    glycol    macroscopic    organization    cord    organs    engineer    realize    polymerization    hydrogels    repair    scaffold    tissues    microgels    physiological    matrix    mimic    invasive    ethylene    density    technique    situ    hydrogel    biomaterial    ratio    fraction    function    experiments    barrel    decisive    composites    clinical    group    optimize    microgel    effect    interlocked    bio    cells    dimensions    tissue    spinal    succesful    healing    structure    injectable    superparamagnetic    shape    structural    volume    pathological    injected    functional    minimal    assemble    microheterogeneous    injury    orientation    behavior    self    signaling    rat    vitro    crosslinking   

Project "ANISOGEL" data sheet

The following table provides information about the project.

Coordinator
DWI LEIBNIZ-INSTITUT FUR INTERAKTIVE MATERIALIEN EV 

Organization address
address: FORCKENBECKSTRASSE 50
city: AACHEN
postcode: 52074
website: www.dwi.rwth-aachen.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website https://www.dwi.rwth-aachen.de/index.php
 Total cost 1˙435˙396 €
 EC max contribution 1˙435˙396 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-STG
 Funding Scheme ERC-STG
 Starting year 2015
 Duration (year-month-day) from 2015-03-01   to  2021-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    DWI LEIBNIZ-INSTITUT FUR INTERAKTIVE MATERIALIEN EV DE (AACHEN) coordinator 1˙435˙396.00

Map

 Project objective

This project will engineer an injectable biomaterial that forms an anisotropic microheterogeneous structure in vivo. Injectable hydrogels enable a minimal invasive in situ generation of matrices for the regeneration of tissues and organs, but currently lack structural organization and unidirectional orientation. The anisotropic, injectable hydrogels to be developed will mimic local extracellular matrix architectures that cells encounter in complex tissues (e.g. nerves, muscles). This project aims for the development of a biomimetic scaffold for spinal cord regeneration. To realize such a major breakthrough, my group will focus on three research objectives. i) Poly(ethylene glycol) microgel-in-hydrogel matrices will be fabricated with the ability to create macroscopic order due to microgel shape anisotropy and magnetic alignment. Barrel-like microgels will be prepared using an in-mold polymerization technique. Their ability to self-assemble will be investigated in function of their dimensions, aspect ratio, crosslinking density, and volume fraction. Superparamagnetic nanoparticles will be included into the microgels to enable unidirectional orientation by means of a magnetic field. Subsequently, the oriented microgels will be interlocked within a master hydrogel. ii) The microgel-in-hydrogel matrices will be equipped with (bio)functional properties for spinal cord regeneration, i.e., to control and optimize mechanical anisotropy and biological signaling by in vitro cell growth experiments. iii) Selected hydrogel composites will be injected after rat spinal cord injury and directional tissue growth and animal functional behavior will be analyzed. Succesful fabrication of the proposed microgel-in-hydrogel matrix will provide a new type of biomaterial, which enables investigating the effect of an anisotropic structure on physiological and pathological processes in vivo. This is a decisive step towards creating a clinical healing matrix for anisotropic tissue repair.

 Publications

year authors and title journal last update
List of publications.
2017 Abdolrahman Omidinia-Anarkoli, Sarah Boesveld, Urandelger Tuvshindorj, Jonas C. Rose, Tamás Haraszti, Laura De Laporte
An Injectable Hybrid Hydrogel with Oriented Short Fibers Induces Unidirectional Growth of Functional Nerve Cells
published pages: 1702207, ISSN: 1613-6810, DOI: 10.1002/smll.201702207
Small 13/36 2020-01-24
2018 Jonas C. Rose, Laura De Laporte
Hierarchical Design of Tissue Regenerative Constructs
published pages: 1701067, ISSN: 2192-2640, DOI: 10.1002/adhm.201701067
Advanced Healthcare Materials 2020-01-24
2017 Jonas C. Rose, María Cámara-Torres, Khosrow Rahimi, Jens Köhler, Martin Möller, Laura De Laporte
Nerve Cells Decide to Orient inside an Injectable Hydrogel with Minimal Structural Guidance
published pages: 3782-3791, ISSN: 1530-6984, DOI: 10.1021/acs.nanolett.7b01123
Nano Letters 17/6 2020-01-24
2018 Jonas C. Rose, David B. Gehlen, Tamás Haraszti, Jens Köhler, Christopher J. Licht, Laura De Laporte
Biofunctionalized aligned microgels provide 3D cell guidance to mimic complex tissue matrices
published pages: 128-141, ISSN: 0142-9612, DOI: 10.1016/j.biomaterials.2018.02.001
Biomaterials 163 2020-01-24

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The information about "ANISOGEL" are provided by the European Opendata Portal: CORDIS opendata.

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