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SQUALAC

Preclinical development of squalenic acid and gemcitabine squalene nanomedicine

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 SQUALAC project word cloud

Explore the words cloud of the SQUALAC project. It provides you a very rough idea of what is the project "SQUALAC" about.

cancer    compound    incidentally    display    moiety    synthesis    nanomedicines    overcome    excessive    shown    triggered    innovation    yield    excipient    remarkably    drug    confers    construct    spacer    pharmaceutical    folded    employed    course    parent    hunting    first    clinic    bioconjugates    pancreatic    sq    lipid    regulatory    disease    laquo    remarkable    lock    linkage    gem    reaction    goals    candidate    sqco2h    grant    acceptable    economical    acid    drugs    bioconjugate    shark    itself    conformation    cosmetics    chemical    ing    chemistry    environmental    translation    resistance    platform    clinical    squalenoylation    perform    deserve    total    green    discovered    anticancer    treatment    tumor    raquo    experimental    self    template    tamelen    nanomedicine    tumors    cro3    impressive    gemcitabine    ternanomed    preparation    nanoparticles    therapy    squalene    release    never    squalenic    molecular    natural    efficient    van    loading    erc    data    assemble    property    devastating    poor    toxic   

Project "SQUALAC" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITE PARIS-SUD 

Organization address
address: RUE GEORGES CLEMENCEAU 15
city: ORSAY CEDEX
postcode: 91405
website: www.u-psud.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 150˙000 €
 EC max contribution 150˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-PoC
 Funding Scheme ERC-POC
 Starting year 2015
 Duration (year-month-day) from 2015-03-01   to  2016-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE PARIS-SUD FR (ORSAY CEDEX) coordinator 150˙000.00

Map

 Project objective

'In the course of the ERC Advanced Grant TERNANOMED, we have discovered that the linkage of squalene (a natural lipid) to many drugs, confers to the resulting bioconjugates the remarkable property to self-assemble as nanoparticles, due to the folded molecular conformation of squalene. This approach is unique and has never been used before. The so called 'squalenoylation' technology may be considered as a generic platform to construct nanomedicines with high drug loading and targeted drug release triggered by the spacer between the drug and the squalene moiety. Remarkably, it was shown that these nanomedicines were more efficient and less toxic than the parent drugs. The gemcitabine-squalene (Gem-SQ) nanomedicine, our first candidate for further pharmaceutical developments, was shown not only to display an impressive anticancer activity in experimental tumors but also to overcome drug resistance, thus addressing a major challenge in tumor therapy. These pre-clinical data deserve further development towards translation into the clinic for the treatment of the pancreatic cancer, a devastating disease. However, the squalenic acid (SQCO2H), the chemical template essential for the synthesis of the Gem-SQ bioconjugate, is currently obtained through the Van Tamelen reaction which cannot be employed for the preparation of a clinical sample of Gem-SQ, because of the use of CrO3 (a toxic compound) and the poor yield of the reaction. Therefore, the synthesis of SQCO2H represents a lock for further clinical development of our Gem-SQ nanomedicine. The goals of the present proposal are : (i) to perform the total synthesis of SQCO2H through a new « green » chemistry way (which represents in itself a real innovation) allowing (ii) further regulatory acceptable preparation of Gem-SQ nanoparticles. Incidentally, the total synthesis of SQCO2H will avoid environmental concern due to excessive shark hunting and represents by itself some economical value as excipient for the cosmetics.'

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The information about "SQUALAC" are provided by the European Opendata Portal: CORDIS opendata.

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