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SQUALAC

Preclinical development of squalenic acid and gemcitabine squalene nanomedicine

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 SQUALAC project word cloud

Explore the words cloud of the SQUALAC project. It provides you a very rough idea of what is the project "SQUALAC" about.

green    remarkably    compound    folded    toxic    template    clinic    efficient    conformation    sq    pancreatic    data    tumor    loading    cro3    first    translation    preparation    bioconjugates    acceptable    squalene    yield    acid    overcome    treatment    shark    lipid    parent    display    excipient    cosmetics    gem    ing    incidentally    discovered    assemble    gemcitabine    moiety    nanomedicine    synthesis    deserve    goals    poor    grant    devastating    economical    cancer    tumors    therapy    drugs    experimental    resistance    confers    reaction    innovation    total    employed    raquo    molecular    never    lock    release    construct    pharmaceutical    van    nanomedicines    squalenic    perform    environmental    erc    remarkable    drug    ternanomed    course    triggered    nanoparticles    bioconjugate    anticancer    chemical    regulatory    chemistry    natural    linkage    candidate    disease    impressive    squalenoylation    laquo    clinical    hunting    property    tamelen    excessive    platform    sqco2h    itself    spacer    self    shown   

Project "SQUALAC" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITE PARIS-SUD 

Organization address
address: RUE GEORGES CLEMENCEAU 15
city: ORSAY CEDEX
postcode: 91405
website: www.u-psud.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 150˙000 €
 EC max contribution 150˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-PoC
 Funding Scheme ERC-POC
 Starting year 2015
 Duration (year-month-day) from 2015-03-01   to  2016-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE PARIS-SUD FR (ORSAY CEDEX) coordinator 150˙000.00

Map

 Project objective

'In the course of the ERC Advanced Grant TERNANOMED, we have discovered that the linkage of squalene (a natural lipid) to many drugs, confers to the resulting bioconjugates the remarkable property to self-assemble as nanoparticles, due to the folded molecular conformation of squalene. This approach is unique and has never been used before. The so called 'squalenoylation' technology may be considered as a generic platform to construct nanomedicines with high drug loading and targeted drug release triggered by the spacer between the drug and the squalene moiety. Remarkably, it was shown that these nanomedicines were more efficient and less toxic than the parent drugs. The gemcitabine-squalene (Gem-SQ) nanomedicine, our first candidate for further pharmaceutical developments, was shown not only to display an impressive anticancer activity in experimental tumors but also to overcome drug resistance, thus addressing a major challenge in tumor therapy. These pre-clinical data deserve further development towards translation into the clinic for the treatment of the pancreatic cancer, a devastating disease. However, the squalenic acid (SQCO2H), the chemical template essential for the synthesis of the Gem-SQ bioconjugate, is currently obtained through the Van Tamelen reaction which cannot be employed for the preparation of a clinical sample of Gem-SQ, because of the use of CrO3 (a toxic compound) and the poor yield of the reaction. Therefore, the synthesis of SQCO2H represents a lock for further clinical development of our Gem-SQ nanomedicine. The goals of the present proposal are : (i) to perform the total synthesis of SQCO2H through a new « green » chemistry way (which represents in itself a real innovation) allowing (ii) further regulatory acceptable preparation of Gem-SQ nanoparticles. Incidentally, the total synthesis of SQCO2H will avoid environmental concern due to excessive shark hunting and represents by itself some economical value as excipient for the cosmetics.'

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The information about "SQUALAC" are provided by the European Opendata Portal: CORDIS opendata.

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