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HYPOXFLU

[18F]Fluorination of alkylCF3 and alkylCF2CF3 chains-Application to hypoxia biomarkers for PET imaging.

Total Cost €

0

EC-Contrib. €

0

Partnership

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Project "HYPOXFLU" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD 

Organization address
address: WELLINGTON SQUARE UNIVERSITY OFFICES
city: OXFORD
postcode: OX1 2JD
website: www.ox.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website http://users.ox.ac.uk/
 Total cost 195˙454 €
 EC max contribution 195˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-03-16   to  2017-03-15

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD UK (OXFORD) coordinator 195˙454.00

Map

 Project objective

The first objective of this proposal is to provide a solution to a well recognized problem in 18F-radiochemistry: the direct [18F]fluorination of trifluoromethylated and perfluorinated (CF2-CF3) alkyl chains. We propose to investigate a copper-mediated fluorination of alkyl boronic species using [18F]fluoride. The value of this new radiochemistry will be challenged with the synthesis and the labelling of two well-known and promising biomarkers for hypoxia, EF3 and EF5. We propose to develop an automated protocol for the production of their radiolabelled counterparts, and to perform a pre-clinical comparative study of [18F]EF3 and [18F]EF5 with [18F]FMISO, the current hypoxia biomarker used for PET imaging.

 Publications

year authors and title journal last update
List of publications.
2015 Miriam O’Duill, Emmanuelle Dubost, Lukas Pfeifer, and Veronique Gouverneur
Cross-Coupling of [2-Aryl-1,1,2,2-tetrafluoroethyl](trimethyl)silaneswith Aryl Halides
published pages: , ISSN: 1523-7060, DOI: 10.1021/acs.orglett.5b01510
Organic letters 2019-07-24

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The information about "HYPOXFLU" are provided by the European Opendata Portal: CORDIS opendata.

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