Explore the words cloud of the HYPOXFLU project. It provides you a very rough idea of what is the project "HYPOXFLU" about.
The following table provides information about the project.
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
|Coordinator Country||United Kingdom [UK]|
|Total cost||195˙454 €|
|EC max contribution||195˙454 € (100%)|
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
|Duration (year-month-day)||from 2015-03-16 to 2017-03-15|
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|1||THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD||UK (OXFORD)||coordinator||195˙454.00|
The first objective of this proposal is to provide a solution to a well recognized problem in 18F-radiochemistry: the direct [18F]fluorination of trifluoromethylated and perfluorinated (CF2-CF3) alkyl chains. We propose to investigate a copper-mediated fluorination of alkyl boronic species using [18F]fluoride. The value of this new radiochemistry will be challenged with the synthesis and the labelling of two well-known and promising biomarkers for hypoxia, EF3 and EF5. We propose to develop an automated protocol for the production of their radiolabelled counterparts, and to perform a pre-clinical comparative study of [18F]EF3 and [18F]EF5 with [18F]FMISO, the current hypoxia biomarker used for PET imaging.
|year||authors and title||journal||last update|
Miriam Oâ€™Duill, Emmanuelle Dubost, Lukas Pfeifer, and Veronique Gouverneur
Cross-Coupling of [2-Aryl-1,1,2,2-tetrafluoroethyl](trimethyl)silaneswith Aryl Halides
published pages: , ISSN: 1523-7060, DOI: 10.1021/acs.orglett.5b01510
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The information about "HYPOXFLU" are provided by the European Opendata Portal: CORDIS opendata.
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