CONQUER project deliverables
The page lists 16 deliverables related to the research project "CONQUER".
List of Deliverables
| title and desprition | type | last update |
|---|---|---|
Extended quantum-mechanical modelTheoretical models and simulations for systems containing QN and paramagnetic ions, different kinds of QN, will be developed to explore the possibilities offered by multi-quantum effects. Although a comprehensive model is necessary for predicting in detail the contrast properties of the CA, we will also develop simplified, phenomenological ‗master rules‘ relating the shape of the NQR-CR peaks with structural and dynamical parameters. Due to their complexity the developed models will be thoroughly tested against experiments Programme: H2020-EU.1.2.1. - Topic(s): FETOPEN-RIA-2014-2015 |
Documents, reports | 2019-05-31 |
Relaxometry data base tuned NPs1H NMR Field Cycling studies for the final, fine-tuned compounds synthetised by WPs 3 and 4 will be carried out. The results will again be documented and stored in a database. Programme: H2020-EU.1.2.1. - Topic(s): FETOPEN-RIA-2014-2015 |
Documents, reports | 2019-05-31 |
ZF-NQRS databaseZero field NQRS of promising prototype compounds from WP3 will be carried out. From the spectra the resonance frequencies and the facor eta will be deduced and the quantum-chemical computations in WP3 will be validated. The relative strength of the NQR peaks and the NQR relaxation times will be characterised to study the magnitude of the effects in different compounds. All data will be stored in a database. Programme: H2020-EU.1.2.1. - Topic(s): FETOPEN-RIA-2014-2015 |
Documents, reports | 2019-05-31 |
Relaxometry database prototyping1H NMR Field Cycling studies for selected prototype compounds synthesised by WPs 3 and 4 will be carried out. Preliminary measurements will be carried out in parallel to the theoretical simulations. The preliminary studies will be followed by detailed experimental investigations of specific systems selected on the basis of simulations to confirm or negate their potential as CA. All experimental results will be documented and stored in a database. Programme: H2020-EU.1.2.1. - Topic(s): FETOPEN-RIA-2014-2015 |
Documents, reports | 2019-05-31 |
Report on publications and eventsReport on publications (journal and book articles, patents etc. as well as events such as workshops and mini-symposia on conferences. Programme: H2020-EU.1.2.1. - Topic(s): FETOPEN-RIA-2014-2015 |
Documents, reports | 2019-05-31 |
Cytotoxicity, uptake, inflammationCell cultures for MRI experiments will be prepared. Absence of biological contamination, sufficient cellular uptake and lack of adverse cellular effects will be shown with endothelial cells and blood cells. Contamination will be detected by subjecting the NPs to limulus amoebocyte lysate assay to test endotoxin levels Cytotoxicity and potential influence on the immune system will be studied and documented. Programme: H2020-EU.1.2.1. - Topic(s): FETOPEN-RIA-2014-2015 |
Documents, reports | 2019-05-31 |
Dextran based NPs characterisedImmobilisation of the most promising candidates from WP3 (TUG) in terms of NQR frequencies onto dextranes differing in molecular weight and the degree of branching. The immobilisation will be performed by reacting the Bi compounds bearing a functional spacer group (e.g. carboxylic groups) with the polymers. For example, carbodiimide chemistry is a well-known procedure for coupling OH with COOH groups in a very efficient way, and several literature procedures are known. Programme: H2020-EU.1.2.1. - Topic(s): FETOPEN-RIA-2014-2015 |
Documents, reports | 2019-05-31 |
Modified MRI scanner characterised\"The existing clinical 3T scanner will be equipped with a coil insert for shifting B0 so as to change the NQR-CR (custom manufacturing by \"\"Resonance Research\"\"). The RF coils used will be dedicated animal coils. Programme: H2020-EU.1.2.1. - Topic(s): FETOPEN-RIA-2014-2015 |
Documents, reports | 2019-05-31 |
Tuned NPs characterisedAfter optimisation of the prototype particle system (size, chemistry and hydrophilicity the NQR properties will be tuned in order to fulfil the 3T conditions. Thus a fine tuning of the particle size, shape and slight chemical modifications may be required. Programme: H2020-EU.1.2.1. - Topic(s): FETOPEN-RIA-2014-2015 |
Documents, reports | 2019-05-31 |
Scientific papers of reporting period 28 Scientific papers planned on theoretical modelling, synthesis of NQR-CR compounds and their characterisation as well as on toxicology and imaging results. Papers on the proof of concept. Programme: H2020-EU.1.2.1. - Topic(s): FETOPEN-RIA-2014-2015 |
Documents, reports | 2019-05-31 |
Data management planDetailed rules for data management, enabling data exchange by supplying appropriate channels and assurance of data security (server management). Programme: H2020-EU.1.2.1. - Topic(s): FETOPEN-RIA-2014-2015 |
Open Research Data Pilot | 2019-05-31 |
Evaluation of NQR-CR with MRITest of uptake of particles into endothelial cells and into human PBMCs by microscopy and MRI. MRI will be done after cells have been incubated with different dilutions of the NPs and embedded in agarose. Contrast changes due to switching of B0 in phantoms and in cell cultures after cellular uptake will be studied and documented. Programme: H2020-EU.1.2.1. - Topic(s): FETOPEN-RIA-2014-2015 |
Documents, reports | 2019-05-31 |
Scientific papers of reporting period 13 Scientific papers planned on theoretical modelling, synthesis of NQR-CR compounds and their characterisation. Programme: H2020-EU.1.2.1. - Topic(s): FETOPEN-RIA-2014-2015 |
Documents, reports | 2019-05-31 |
Quantum-mechanical model 1An NQR-modeling approach which has been developed for solids will be extended towards different motional scenarios to account for rotational, translational and internal dynamics as well as exchange processes. Existing numerical tools will be used for initial simulations but the software will be continuously developed to account for the complex relaxation scenario. Optimisation is likely to be required as the computational complexity increases significantly for high spin (9/2) nuclei. Where necessary, the quantum-mechanical models will be combined with molecular dynamics simulations. Programme: H2020-EU.1.2.1. - Topic(s): FETOPEN-RIA-2014-2015 |
Documents, reports | 2019-05-31 |
NQR-CR polymers characterisedImmobilisation of the most promising candidates from WP3 in terms of NQR frequencies onto PEG differing in molecular weight and the degree of branching. The immobilisation will be performed by reacting the Bi compounds bearing a functional spacer group (e.g. carboxylic groups) with the polymers. For example, carbodiimide chemistry is a well-known procedure for coupling OH with COOH groups in a very efficient way, and several literature procedures are known. Programme: H2020-EU.1.2.1. - Topic(s): FETOPEN-RIA-2014-2015 |
Documents, reports | 2019-05-30 |
Webpage with open access databaseDesign and implementation of a webpage for communicating general information and results, providing open access to data and for facilitating networking activities. Programme: H2020-EU.1.2.1. - Topic(s): FETOPEN-RIA-2014-2015 |
Other | 2019-05-31 |