Opendata, web and dolomites

COSMOS SIGNED

Control and measurement of single macromolecules in space and time

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 COSMOS project word cloud

Explore the words cloud of the COSMOS project. It provides you a very rough idea of what is the project "COSMOS" about.

snapshot    stable    confinement    representing    experimentally    reveals    destructive    size    desire    trap    microscopy    traced    dynamics    tweezing    transport    conformation    catalog    platform    external    throughput    physical    examine    back    fluidic    temperature    basis    cell    fundamental    solution    time    electrostatic    structure    particles    macromolecules    conformational    proteome    frequency    differences    generating    function    suspend    measuring    macromolecule    transcriptome    diaries    radio    single    perturb    rely    3d    free    biological    trapped    interactions    structural    temporal    macromolecular    potentially    room    sensors    analytics    biomolecules    closely    dimension    200    ultrasensitive    integrity    molecules    link    lichtenberg    detection    fluids    colloidal    biomedical    molecular    nearly    space    shift    ion    invented    paradigm    isoforms    traps    supports    century    first    electrostatically    molecule    turn    spatio    minute    electrical    charge    signatures    optical    constituents    read   

Project "COSMOS" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD 

Organization address
address: WELLINGTON SQUARE UNIVERSITY OFFICES
city: OXFORD
postcode: OX1 2JD
website: www.ox.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 2˙124˙965 €
 EC max contribution 2˙124˙965 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-COG
 Funding Scheme ERC-COG
 Starting year 2018
 Duration (year-month-day) from 2018-06-01   to  2023-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD UK (OXFORD) coordinator 2˙124˙965.00
2    UNIVERSITAT ZURICH CH (Zürich) participant 0.00

Map

Leaflet | Map data © OpenStreetMap contributors, CC-BY-SA, Imagery © Mapbox

 Project objective

The desire to “freely suspend the constituents of matter” in order to study their behaviour can be traced back over 200 years to Lichtenberg’s diaries. From radio-frequency ion traps to optical tweezing of colloidal particles, existing methods to trap matter in free space or solution rely on the use of external fields that often strongly perturb the integrity of a macromolecule in solution. Recently, I invented the ‘electrostatic fluidic trap’, a “field-free” principle that supports stable, non-destructive confinement of single macromolecules in room temperature fluids, representing a paradigm shift in a nearly century-old field. The spatio-temporal dynamics of a single electrostatically trapped molecule reveals fundamental information on its properties, e.g., size and electrical charge. The charge of a macromolecule is in turn a strong function of its 3D conformation - the molecular basis of biological function. I now aim to develop a new platform to study 3D macromolecular structure and temporal conformation by measuring the electrical charge of a single trapped molecule in real time, using both optical microscopy and electrical detection. Beyond the conformational dynamics of a single molecule, we will also examine interactions between two or more molecules, and the detection of minute structural differences between closely related molecular isoforms. We will further develop a novel approach to electrical transport measurements on single molecules aimed at generating for the first time a catalog of ‘electrical signatures’ for biomolecules in solution. The ability to experimentally link electrical charge and molecular structure will not only open up a new physical dimension in our understanding of macromolecules, but also advance the development of ultrasensitive, high-throughput molecular sensors for biomedical detection and analytics, potentially enabling an optical or electrical “single-snapshot” read-out of the proteome or transcriptome of a single cell.

 Publications

year authors and title journal last update
List of publications.
2019 Maria I Bespalova, Sushanta Mahanta, Madhavi Krishnan
Single-molecule trapping and measurement in solution
published pages: 113-121, ISSN: 1367-5931, DOI: 10.1016/j.cbpa.2019.05.013
Current Opinion in Chemical Biology 51 2020-02-04

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "COSMOS" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "COSMOS" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

EVOCELFATE (2019)

Evolution of cell fate specification modes in spiral cleavage

Read More  

HydroLieve (2018)

A long-lasting non-migrating hydrogel for relieving chronic pain

Read More  

Diverge (2019)

Generation of ultra-deep libraries of transcriptional activators for gene therapy

Read More