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COSMOS SIGNED

Control and measurement of single macromolecules in space and time

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 COSMOS project word cloud

Explore the words cloud of the COSMOS project. It provides you a very rough idea of what is the project "COSMOS" about.

fluidic    potentially    sensors    century    cell    closely    shift    macromolecular    size    detection    microscopy    reveals    fundamental    suspend    function    invented    conformation    external    platform    macromolecule    biomedical    link    frequency    electrostatically    dynamics    turn    temporal    traps    nearly    rely    supports    dimension    lichtenberg    differences    stable    space    200    ion    traced    fluids    experimentally    charge    ultrasensitive    read    confinement    catalog    integrity    first    electrical    physical    diaries    signatures    free    transcriptome    molecule    generating    biomolecules    measuring    trapped    molecular    interactions    spatio    electrostatic    throughput    paradigm    room    structural    snapshot    transport    constituents    particles    single    isoforms    molecules    minute    biological    tweezing    examine    radio    temperature    optical    perturb    desire    conformational    destructive    back    time    structure    proteome    trap    colloidal    3d    solution    basis    macromolecules    representing    analytics   

Project "COSMOS" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD 

Organization address
address: WELLINGTON SQUARE UNIVERSITY OFFICES
city: OXFORD
postcode: OX1 2JD
website: www.ox.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 2˙124˙965 €
 EC max contribution 2˙124˙965 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-COG
 Funding Scheme ERC-COG
 Starting year 2018
 Duration (year-month-day) from 2018-06-01   to  2023-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD UK (OXFORD) coordinator 2˙124˙965.00
2    UNIVERSITAT ZURICH CH (Zürich) participant 0.00

Map

 Project objective

The desire to “freely suspend the constituents of matter” in order to study their behaviour can be traced back over 200 years to Lichtenberg’s diaries. From radio-frequency ion traps to optical tweezing of colloidal particles, existing methods to trap matter in free space or solution rely on the use of external fields that often strongly perturb the integrity of a macromolecule in solution. Recently, I invented the ‘electrostatic fluidic trap’, a “field-free” principle that supports stable, non-destructive confinement of single macromolecules in room temperature fluids, representing a paradigm shift in a nearly century-old field. The spatio-temporal dynamics of a single electrostatically trapped molecule reveals fundamental information on its properties, e.g., size and electrical charge. The charge of a macromolecule is in turn a strong function of its 3D conformation - the molecular basis of biological function. I now aim to develop a new platform to study 3D macromolecular structure and temporal conformation by measuring the electrical charge of a single trapped molecule in real time, using both optical microscopy and electrical detection. Beyond the conformational dynamics of a single molecule, we will also examine interactions between two or more molecules, and the detection of minute structural differences between closely related molecular isoforms. We will further develop a novel approach to electrical transport measurements on single molecules aimed at generating for the first time a catalog of ‘electrical signatures’ for biomolecules in solution. The ability to experimentally link electrical charge and molecular structure will not only open up a new physical dimension in our understanding of macromolecules, but also advance the development of ultrasensitive, high-throughput molecular sensors for biomedical detection and analytics, potentially enabling an optical or electrical “single-snapshot” read-out of the proteome or transcriptome of a single cell.

 Publications

year authors and title journal last update
List of publications.
2019 Maria I Bespalova, Sushanta Mahanta, Madhavi Krishnan
Single-molecule trapping and measurement in solution
published pages: 113-121, ISSN: 1367-5931, DOI: 10.1016/j.cbpa.2019.05.013
Current Opinion in Chemical Biology 51 2020-02-04

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