Opendata, web and dolomites

COSMOS SIGNED

Control and measurement of single macromolecules in space and time

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 COSMOS project word cloud

Explore the words cloud of the COSMOS project. It provides you a very rough idea of what is the project "COSMOS" about.

dynamics    molecules    electrostatically    measuring    physical    potentially    radio    ultrasensitive    throughput    size    differences    trap    charge    biological    fluidic    conformational    transcriptome    temperature    proteome    time    desire    tweezing    transport    3d    biomedical    rely    invented    optical    fundamental    basis    back    macromolecular    cell    solution    reveals    diaries    lichtenberg    traps    space    signatures    link    electrical    frequency    temporal    destructive    200    ion    trapped    traced    representing    molecule    macromolecule    conformation    examine    colloidal    electrostatic    platform    free    first    macromolecules    single    read    particles    interactions    constituents    molecular    isoforms    room    dimension    external    perturb    suspend    fluids    paradigm    analytics    generating    minute    nearly    shift    microscopy    catalog    detection    biomolecules    confinement    snapshot    turn    function    supports    closely    experimentally    structural    stable    integrity    century    sensors    structure    spatio   

Project "COSMOS" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD 

Organization address
address: WELLINGTON SQUARE UNIVERSITY OFFICES
city: OXFORD
postcode: OX1 2JD
website: www.ox.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 2˙124˙965 €
 EC max contribution 2˙124˙965 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-COG
 Funding Scheme ERC-COG
 Starting year 2018
 Duration (year-month-day) from 2018-06-01   to  2023-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD UK (OXFORD) coordinator 2˙124˙965.00
2    UNIVERSITAT ZURICH CH (Zürich) participant 0.00

Map

 Project objective

The desire to “freely suspend the constituents of matter” in order to study their behaviour can be traced back over 200 years to Lichtenberg’s diaries. From radio-frequency ion traps to optical tweezing of colloidal particles, existing methods to trap matter in free space or solution rely on the use of external fields that often strongly perturb the integrity of a macromolecule in solution. Recently, I invented the ‘electrostatic fluidic trap’, a “field-free” principle that supports stable, non-destructive confinement of single macromolecules in room temperature fluids, representing a paradigm shift in a nearly century-old field. The spatio-temporal dynamics of a single electrostatically trapped molecule reveals fundamental information on its properties, e.g., size and electrical charge. The charge of a macromolecule is in turn a strong function of its 3D conformation - the molecular basis of biological function. I now aim to develop a new platform to study 3D macromolecular structure and temporal conformation by measuring the electrical charge of a single trapped molecule in real time, using both optical microscopy and electrical detection. Beyond the conformational dynamics of a single molecule, we will also examine interactions between two or more molecules, and the detection of minute structural differences between closely related molecular isoforms. We will further develop a novel approach to electrical transport measurements on single molecules aimed at generating for the first time a catalog of ‘electrical signatures’ for biomolecules in solution. The ability to experimentally link electrical charge and molecular structure will not only open up a new physical dimension in our understanding of macromolecules, but also advance the development of ultrasensitive, high-throughput molecular sensors for biomedical detection and analytics, potentially enabling an optical or electrical “single-snapshot” read-out of the proteome or transcriptome of a single cell.

 Publications

year authors and title journal last update
List of publications.
2019 Maria I Bespalova, Sushanta Mahanta, Madhavi Krishnan
Single-molecule trapping and measurement in solution
published pages: 113-121, ISSN: 1367-5931, DOI: 10.1016/j.cbpa.2019.05.013
Current Opinion in Chemical Biology 51 2020-02-04

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "COSMOS" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "COSMOS" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

DISINTEGRATION (2019)

The Mass Politics of Disintegration

Read More  

PROGRESS (2019)

The Enemy of the Good: Towards a Theory of Moral Progress

Read More  

Neurovulnerability (2019)

Molecular mechanisms underlying selective neuronal death in motor neuron diseases

Read More