Explore the words cloud of the AD-gut project. It provides you a very rough idea of what is the project "AD-gut" about.
The following table provides information about the project.
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
|Coordinator Country||Switzerland [CH]|
|Total cost||7˙686˙620 €|
|EC max contribution||5˙092˙886 € (66%)|
1. H2020-EU.2.1.3. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies - Advanced materials)
|Duration (year-month-day)||from 2016-04-01 to 2020-03-31|
Take a look of project's partnership.
|1||ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE||CH (LAUSANNE)||coordinator||0.00|
|2||MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV||DE (MUENCHEN)||participant||1˙551˙003.00|
|3||KATHOLIEKE UNIVERSITEIT LEUVEN||BE (LEUVEN)||participant||1˙499˙810.00|
|4||LUNDS UNIVERSITET||SE (LUND)||participant||1˙287˙403.00|
|5||VIB VZW||BE (ZWIJNAARDE - GENT)||participant||754˙668.00|
|6||UNIVERSITAET BERN||CH (BERN)||participant||0.00|
Alzheimer’s disease (AD) is the leading cause of dementia in the Western world and to date no cure nor any preventive strategy are available for this neurodegenerative disorder. Bacterial 16S rRNA sequencing from fecal samples revealed a remarkable shift in the gut microbiota of conventionally-raised AD mice compared to healthy, wild-type mice. Based on these findings, we generated germ-free Alzheimer (GF-AD) mouse model and discovered a drastic reduction of cerebral Aβ amyloid pathology when compared to control AD mice with natural intestinal microbiota. In contrast, fecal transplantation of GF-AD with harvested microbiota from conventionally-raised AD mice dramatically increased cerebral Aβ pathology.
Altogether, these results strongly support a microbial involvement in the development of AD and show how gut microbiome modulation can slow down or halt its onset. This paves the road to new indirect diagnostic and therapeutic approaches for AD prevention, based on gut microbiota modulation through probiotic cocktails.
Based on these findings, the present proposal aims at designing and optimizing an efficient encapsulation strategy to guarantee the survival and the delivery of probiotic strains in the gut as opposed to standard strategies targeting directly the brain. A successful accomplishment of this goal will also allow to derive AD risk factors and to establish an objective baseline setting for AD diagnosis. Ultimately, the present project will open new horizons in biomedical diagnostics and personalized medicine through the marketing of these technologies and therapeutic concepts.
|Production of m-MOOCs||Websites, patent fillings, videos etc.||2019-08-29 13:02:42|
|Workshop||Websites, patent fillings, videos etc.||2019-08-29 13:02:41|
|Creation of website||Websites, patent fillings, videos etc.||2019-08-29 13:02:41|
|Mid-term press release||Websites, patent fillings, videos etc.||2019-08-29 13:02:42|
Take a look to the deliverables list in detail: detailed list of AD-gut deliverables.
|year||authors and title||journal||last update|
Christiane Seidler, Maksymilian Marek Zegota, Marco Raabe, Seah Ling Kuan, David Y. W. Ng, Tanja Weil
Dynamic Core-Shell Bioconjugates for Targeted Protein Delivery and Release
published pages: 3474-3479, ISSN: 1861-4728, DOI: 10.1002/asia.201800843
|Chemistry - An Asian Journal 13/22||2019-06-06|
M. Pieszka, A. M. Sobota, J. GaÄanin, T. Weil, D. Y. W. Ng
Orthogonally Stimulated Assembly/Disassembly of Depsiâ€peptides by Rational Chemical Design
published pages: , ISSN: 1439-7633, DOI: 10.1002/cbic.201800781m
Wang, Y.; Horlamus, F.; Henkel, M.; Kovacic, F.; Schlaefle, S.; Hausmann, R.; Wittgens, A.; Rosenau, F.
Growth of engineered Pseudomonas putida KT2440 on glucose, xylose, and arabinose: Hemicellulose hydrolysates and their major sugars as sustainable carbon sources
published pages: , ISSN: 1757-1693, DOI: 10.1111/gcbb.12590
|GCB Bioenergy 11||2019-05-15|
K. Dâ€™hoe, S. Vet, K. Faust, F. Moens, G. Falony, D. Gonze, V. Llorens-Rico, L. Gelens, J. Danckaert, L. De Vuyst and J. Raes
Integrated culturing, modeling and transcriptomics uncovers complex interactions and emergent behavior in a three-species synthetic gut community
published pages: , ISSN: 2050-084X, DOI: 10.7554/elife.37090
T. Harach, N. Marungruang, N. Duthilleul, V. Cheatham, K. D. Mc Coy, G. Frisoni, J. J. Neher, F. FÃ¥k, M. Jucker, T. Lasser, T. Bolmont
Reduction of Abeta amyloid pathology in APPPS1 transgenic mice in the absence of gut microbiota
published pages: , ISSN: 2045-2322, DOI: 10.1038/srep41802
|Scientific Reports 7/1||2019-05-15|
G. R. B. Huys, J. Raes
Go with the flow or solitary confinement: a look inside the single-cell toolbox for isolation of rare and uncultured microbes
published pages: 1/8, ISSN: 1369-5274, DOI: 10.1016/j.mib.2018.05.002
|Current Opinion in Microbiology Vol. 44||2019-05-15|
GaÄanin, J.; Hedrich, J.; Sieste, S.; Glasser, G.; Lieberwirth, I.; Schilling, C.; Fischer, S.; Barth, H.; Knoell, B.; Synatschke, C.; Weil, T.
Autonomous Ultrafast Self-Healing Hydrogels by pH-Responsive Functional Nanofiber Gelators as Cell Matrices
published pages: , ISSN: 0935-9648, DOI: 10.1002/adma.201805044
|Advanced Materials 31||2019-05-15|
Are you the coordinator (or a participant) of this project? Plaese send me more information about the "AD-GUT" project.
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The information about "AD-GUT" are provided by the European Opendata Portal: CORDIS opendata.
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