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AD-gut SIGNED

Alzheimer Disease - gut connection

Total Cost €

0

EC-Contrib. €

0

Partnership

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Project "AD-gut" data sheet

The following table provides information about the project.

Coordinator
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE 

Organization address
address: BATIMENT CE 3316 STATION 1
city: LAUSANNE
postcode: 1015
website: www.epfl.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Project website http://adgut.eu/
 Total cost 7˙686˙620 €
 EC max contribution 5˙092˙886 € (66%)
 Programme 1. H2020-EU.2.1.3. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies - Advanced materials)
 Code Call H2020-NMP-2015-two-stage
 Funding Scheme RIA
 Starting year 2016
 Duration (year-month-day) from 2016-04-01   to  2020-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE CH (LAUSANNE) coordinator 0.00
2    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (MUENCHEN) participant 1˙551˙003.00
3    KATHOLIEKE UNIVERSITEIT LEUVEN BE (LEUVEN) participant 1˙499˙810.00
4    LUNDS UNIVERSITET SE (LUND) participant 1˙287˙403.00
5    VIB VZW BE (ZWIJNAARDE - GENT) participant 754˙668.00
6    UNIVERSITAET BERN CH (BERN) participant 0.00

Map

 Project objective

Alzheimer’s disease (AD) is the leading cause of dementia in the Western world and to date no cure nor any preventive strategy are available for this neurodegenerative disorder. Bacterial 16S rRNA sequencing from fecal samples revealed a remarkable shift in the gut microbiota of conventionally-raised AD mice compared to healthy, wild-type mice. Based on these findings, we generated germ-free Alzheimer (GF-AD) mouse model and discovered a drastic reduction of cerebral Aβ amyloid pathology when compared to control AD mice with natural intestinal microbiota. In contrast, fecal transplantation of GF-AD with harvested microbiota from conventionally-raised AD mice dramatically increased cerebral Aβ pathology.

Altogether, these results strongly support a microbial involvement in the development of AD and show how gut microbiome modulation can slow down or halt its onset. This paves the road to new indirect diagnostic and therapeutic approaches for AD prevention, based on gut microbiota modulation through probiotic cocktails.

Based on these findings, the present proposal aims at designing and optimizing an efficient encapsulation strategy to guarantee the survival and the delivery of probiotic strains in the gut as opposed to standard strategies targeting directly the brain. A successful accomplishment of this goal will also allow to derive AD risk factors and to establish an objective baseline setting for AD diagnosis. Ultimately, the present project will open new horizons in biomedical diagnostics and personalized medicine through the marketing of these technologies and therapeutic concepts.

 Deliverables

List of deliverables.
Production of m-MOOCs Websites, patent fillings, videos etc. 2019-08-29 13:02:42
Workshop Websites, patent fillings, videos etc. 2019-08-29 13:02:41
Creation of website Websites, patent fillings, videos etc. 2019-08-29 13:02:41
Mid-term press release Websites, patent fillings, videos etc. 2019-08-29 13:02:42

Take a look to the deliverables list in detail:  detailed list of AD-gut deliverables.

 Publications

year authors and title journal last update
List of publications.
2018 Christiane Seidler, Maksymilian Marek Zegota, Marco Raabe, Seah Ling Kuan, David Y. W. Ng, Tanja Weil
Dynamic Core-Shell Bioconjugates for Targeted Protein Delivery and Release
published pages: 3474-3479, ISSN: 1861-4728, DOI: 10.1002/asia.201800843
Chemistry - An Asian Journal 13/22 2019-06-06
2019 M. Pieszka, A. M. Sobota, J. Gačanin, T. Weil, D. Y. W. Ng
Orthogonally Stimulated Assembly/Disassembly of Depsi‐peptides by Rational Chemical Design
published pages: , ISSN: 1439-7633, DOI: 10.1002/cbic.201800781m
ChemBioChem 2019-05-15
2019 Wang, Y.; Horlamus, F.; Henkel, M.; Kovacic, F.; Schlaefle, S.; Hausmann, R.; Wittgens, A.; Rosenau, F.
Growth of engineered Pseudomonas putida KT2440 on glucose, xylose, and arabinose: Hemicellulose hydrolysates and their major sugars as sustainable carbon sources
published pages: , ISSN: 1757-1693, DOI: 10.1111/gcbb.12590
GCB Bioenergy 11 2019-05-15
2018 K. D’hoe, S. Vet, K. Faust, F. Moens, G. Falony, D. Gonze, V. Llorens-Rico, L. Gelens, J. Danckaert, L. De Vuyst and J. Raes
Integrated culturing, modeling and transcriptomics uncovers complex interactions and emergent behavior in a three-species synthetic gut community
published pages: , ISSN: 2050-084X, DOI: 10.7554/elife.37090
eLife 2019-05-15
2017 T. Harach, N. Marungruang, N. Duthilleul, V. Cheatham, K. D. Mc Coy, G. Frisoni, J. J. Neher, F. Fåk, M. Jucker, T. Lasser, T. Bolmont
Reduction of Abeta amyloid pathology in APPPS1 transgenic mice in the absence of gut microbiota
published pages: , ISSN: 2045-2322, DOI: 10.1038/srep41802
Scientific Reports 7/1 2019-05-15
2018 G. R. B. Huys, J. Raes
Go with the flow or solitary confinement: a look inside the single-cell toolbox for isolation of rare and uncultured microbes
published pages: 1/8, ISSN: 1369-5274, DOI: 10.1016/j.mib.2018.05.002
Current Opinion in Microbiology Vol. 44 2019-05-15
2019 Gačanin, J.; Hedrich, J.; Sieste, S.; Glasser, G.; Lieberwirth, I.; Schilling, C.; Fischer, S.; Barth, H.; Knoell, B.; Synatschke, C.; Weil, T.
Autonomous Ultrafast Self-Healing Hydrogels by pH-Responsive Functional Nanofiber Gelators as Cell Matrices
published pages: , ISSN: 0935-9648, DOI: 10.1002/adma.201805044
Advanced Materials 31 2019-05-15

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The information about "AD-GUT" are provided by the European Opendata Portal: CORDIS opendata.

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