Explore the words cloud of the ICRED project. It provides you a very rough idea of what is the project "ICRED" about.
The following table provides information about the project.
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
|Coordinator Country||United Kingdom [UK]|
|Total cost||195˙454 €|
|EC max contribution||195˙454 € (100%)|
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
|Duration (year-month-day)||from 2016-07-11 to 2018-07-10|
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|1||THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD||UK (OXFORD)||coordinator||195˙454.00|
The aim of this fellowship is to develop new reductive cyclization cascades of lactams and amides that establish these feedstock chemicals as important chemical precursors to reactive iminium ions which can be intercepted by pendant nucleophiles and exploited in carbon-carbon bond formation. A range of indole nucleophiles linked to amide and lactam functionality will be investigated for performance in the iridium catalyzed reductive cyclization cascades, and, based on successful proof of concept studies already performed in the Dixon group, a range of semi-saturated nitrogen-containing polycyclic structures possessing one or more stereocentres distributed over an architecturally complex framework should result. As well as studying diastereocontrol in the cascades, catalytic enantioselective variants will also be investigated. Finally, the application of the indole (spiro)cyclization reaction to the total synthesis of aspidospermidine will showcase the utility of the developed chemistry. This multidisciplinary Fellowship, based on high-quality and novel research at the University of Oxford, one of the top-research centres worldwide, will complement Dr Xie’s skills and knowledge to improve his career possibilities and at the same time, Dr Xie’s experience in creating catalytically active transition metal complexes will be critical for developing chiral versions of the iridium catalyst during the development of a catalytic asymmetric version of the reductive cyclization cascade.
|year||authors and title||journal||last update|
Lan-Gui Xie, Darren J. Dixon
Tertiary amine synthesis via reductive coupling of amides with Grignard reagents
published pages: 7492-7497, ISSN: 2041-6520, DOI: 10.1039/c7sc03613b
|Chem. Sci. 8/11||2019-06-13|
Lan-Gui Xie and Darren J. Dixon
Iridium-catalyzed reductive Ugi-type reactions of tertiary amides
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-05192-7
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The information about "ICRED" are provided by the European Opendata Portal: CORDIS opendata.
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