Opendata, web and dolomites

SYNOX

Total Synthesis of Biologically Important Pyrrolidinone Natural Products and Analogues Thereof.

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

Project "SYNOX" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD 

Organization address
address: WELLINGTON SQUARE UNIVERSITY OFFICES
city: OXFORD
postcode: OX1 2JD
website: www.ox.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website http://burton.chem.ox.ac.uk
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-09-01   to  2018-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD UK (OXFORD) coordinator 183˙454.00

Map

 Project objective

'The importance of natural products and derivatives as sources of new drugs is undeniable. Newman has stated:

'It is probably true that if one had to name the natural product that has saved the most lives.....penicillin G would be the molecule of choice' (D. J. Newman, G. M. Cragg, in Natural Product Chemistry for Drug Discovery, Chapter 1, RSC Biolmolecular Sciences No. 18, 2009).

In this proposal we will develop methodology for the synthesis of two types of closely related natural products which have wide-ranging biological activities including: anti-bacterial, anti-viral, anti-tumour and herbicidal activity; but whose biological activities have not been fully evaluated. We will use our recently developed oxidative radical cyclisation methodology to synthesise the cores of these biologically relevant natural products and develop new methodology for the direct functionalisation of certain aromatic heterocycles as part of the synthesis of the unsaturated portions of the natural products. The biological activities, particularly with respect to anti-bacterial and anti-tumour properties of all of the key synthetic intermediates (simplified analogues) and synthetic natural products themselves will be assessed. The project is divided into four work packages involving: i) development of direct functionalisation certain aromatic heterocycles; ii) synthesis of the the one type of natural product; iii) oxidative radical synthesis of natural product cores; iv) total synthesis of the second type of natural product.'

 Publications

year authors and title journal last update
List of publications.
2018 Manjeet Kumar, Liam Bromhead, Zoe Anderson, Alistair Overy, Jonathan W. Burton
Short, Tin-Free Synthesis of All Three Inthomycins
published pages: 16753-16756, ISSN: 0947-6539, DOI: 10.1002/chem.201803794
Chemistry - A European Journal 24/63 2019-05-23

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "SYNOX" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "SYNOX" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

POMOC (2019)

Charles IV and the power of marvellous objects

Read More  

SIMIS (2020)

Strongly Interacting Mass Imbalanced Superfluid with ultracold fermions

Read More  

NaWaTL (2020)

Narrative, Writing, and the Teotihuacan Language: Exploring Language History Through Phylogenetics, Epigraphy and Iconography

Read More