Explore the words cloud of the SYNOX project. It provides you a very rough idea of what is the project "SYNOX" about.
The following table provides information about the project.
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
|Coordinator Country||United Kingdom [UK]|
|Total cost||183˙454 €|
|EC max contribution||183˙454 € (100%)|
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
|Duration (year-month-day)||from 2016-09-01 to 2018-08-31|
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|1||THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD||UK (OXFORD)||coordinator||183˙454.00|
'The importance of natural products and derivatives as sources of new drugs is undeniable. Newman has stated:
'It is probably true that if one had to name the natural product that has saved the most lives.....penicillin G would be the molecule of choice' (D. J. Newman, G. M. Cragg, in Natural Product Chemistry for Drug Discovery, Chapter 1, RSC Biolmolecular Sciences No. 18, 2009).
In this proposal we will develop methodology for the synthesis of two types of closely related natural products which have wide-ranging biological activities including: anti-bacterial, anti-viral, anti-tumour and herbicidal activity; but whose biological activities have not been fully evaluated. We will use our recently developed oxidative radical cyclisation methodology to synthesise the cores of these biologically relevant natural products and develop new methodology for the direct functionalisation of certain aromatic heterocycles as part of the synthesis of the unsaturated portions of the natural products. The biological activities, particularly with respect to anti-bacterial and anti-tumour properties of all of the key synthetic intermediates (simplified analogues) and synthetic natural products themselves will be assessed. The project is divided into four work packages involving: i) development of direct functionalisation certain aromatic heterocycles; ii) synthesis of the the one type of natural product; iii) oxidative radical synthesis of natural product cores; iv) total synthesis of the second type of natural product.'
|year||authors and title||journal||last update|
Manjeet Kumar, Liam Bromhead, Zoe Anderson, Alistair Overy, Jonathan W. Burton
Short, Tin-Free Synthesis of All Three Inthomycins
published pages: 16753-16756, ISSN: 0947-6539, DOI: 10.1002/chem.201803794
|Chemistry - A European Journal 24/63||2019-05-23|
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The information about "SYNOX" are provided by the European Opendata Portal: CORDIS opendata.
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