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MicroRepro SIGNED

Medical microbots to support new assisted reproduction techniques

Total Cost €

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EC-Contrib. €

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Partnership

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 MicroRepro project word cloud

Explore the words cloud of the MicroRepro project. It provides you a very rough idea of what is the project "MicroRepro" about.

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Project "MicroRepro" data sheet

The following table provides information about the project.

Coordinator
LEIBNIZ-INSTITUT FUER FESTKOERPER- UND WERKSTOFFFORSCHUNG DRESDEN E.V. 

Organization address
address: HELMHOLTZSTRASSE 20
city: DRESDEN
postcode: 1069
website: www.ifw-dresden.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 2˙496˙141 €
 EC max contribution 2˙496˙141 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-ADG
 Funding Scheme ERC-ADG
 Starting year 2019
 Duration (year-month-day) from 2019-11-01   to  2024-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    LEIBNIZ-INSTITUT FUER FESTKOERPER- UND WERKSTOFFFORSCHUNG DRESDEN E.V. DE (DRESDEN) coordinator 2˙496˙141.00

Map

 Project objective

Infertility is a health issue with sociological and psychological implications that affects approximately 50 million couples worldwide and therefore receives global attention. Among fertility issues, male infertility is diagnosed in about 40% of all cases and the major causes are poor motility of spermatozoa (asthenospermia), low sperm count (oligospermia), abnormal sperm morphology (teratospermia) and/or combinations of these, leading to their inability to fertilize an oocyte. Such problems have been mainly addressed by artificial insemination (AI) and in vitro fertilization (IVF). AI involves introducing sperms into a woman’s uterus with a medical instrument, but its applicability is limited and its success rate is below 30%. In contrast, IVF and intracytoplasmic sperm injection can be more effective but implicate more invasive procedures such as removing oocytes from a woman’s ovaries, fertilize them outside of the body and then transfer the embryos back to the uterus a few days later. These difficulties demand rethinking of assisted fertilization and the sought after novel approaches that offer more natural procedures with high success rate. Hence, we propose untethered medical microbots to assist sperm cells to fertilize an oocyte in living organisms (mice model). The MicroRepro project will bring advances in areas such as bioimaging, nanomaterials science and fundamental biology, boosting the whole field of medical microbots in the process, as was recently highlighted by the PI in an extended comment [Nature 545, 406(2017)]. The PI has decisively contributed to the field of microrobotics and invented the sperm-robot (Spermbot) concept together with his team in two previous patent applications and several publications. The mere concept has attracted worldwide attention. However, even in vitro fertilization has never been achieved – therefore, targeting the challenges leading to the first spermbot fertilization will be the main objective of this project.

 Publications

year authors and title journal last update
List of publications.
2019 Azaam Aziz, Mariana Medina-Sánchez, Jing Claussen, Oliver G. Schmidt
Real-Time Optoacoustic Tracking of Single Moving Micro-objects in Deep Phantom and Ex Vivo Tissues
published pages: 6612-6620, ISSN: 1530-6984, DOI: 10.1021/acs.nanolett.9b02869
Nano Letters 19/9 2019-11-25
2019 Lukas Schwarz, Mariana Medina-Sanchez, Oliver G. Schmidt
Sperm-hybrid micromotors: on-board assistance for nature\'s bustling swimmers
published pages: , ISSN: 1470-1626, DOI: 10.1530/rep-19-0096
Reproduction 2019-11-25
2019 Azaam Aziz, Mariana Medina‐Sánchez, Nektarios Koukourakis, Jiawei Wang, Robert Kuschmierz, Hannes Radner, Jürgen W. Czarske, Oliver G. Schmidt
Real‐Time IR Tracking of Single Reflective Micromotors through Scattering Tissues
published pages: 1905272, ISSN: 1616-301X, DOI: 10.1002/adfm.201905272
Advanced Functional Materials 2019-11-25

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The information about "MICROREPRO" are provided by the European Opendata Portal: CORDIS opendata.

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