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Fit-The-Fat

IMMUNOMETABOLISM IN HUMAN OBESITY

Total Cost €

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EC-Contrib. €

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Partnership

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Project "Fit-The-Fat" data sheet

The following table provides information about the project.

Coordinator
OSPEDALE SAN RAFFAELE SRL 

Organization address
address: VIA OLGETTINA 60
city: MILANO
postcode: 20132
website: www.hsr.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Project website https://dri.hsr.it
 Total cost 180˙277 €
 EC max contribution 180˙277 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-09-01   to  2019-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    OSPEDALE SAN RAFFAELE SRL IT (MILANO) coordinator 180˙277.00

Map

 Project objective

The incidence of obesity and type 2 diabetes (T2D) are inexorably increasing and elevated healthcare costs related to the higher disease-associated morbidity are affecting European and extra-European countries. Obesity is associated with resistance to the action of insulin (called insulin-resistance) in adipocytes, which is thought to be induced by a low-grade inflammation present in the adipose tissue. Bariatric surgery has been described as the most effective treatment for obesity; however, the pursuit of non-invasive strategies to override obesity-induced insulin-resistance, promote weight loss and restoration of glycemic control is highly needed. In this project will be investigated the hypothesis that T cells residing in the visceral adipose tissue (VAT) are endowed with immunological and metabolic properties that are altered in obese patients and that, in turn, induce insulin-resistance in adipocytes. The following specific Objectives will be accomplished during the fellowship: I. Determine identity, metabolic demands and immunological functions of human VAT-T cells in obese patients and lean subjects; II. Assess the metabolic properties of human VAT-T cells in obese patients and lean subjects; III. Target VAT-T cell-mediated mechanisms of insulin-resistance. In this project, clinical expertise on diabetes and competences in tissue-specific T cell immunology will be merged with cutting-edge technologies in the cellular and molecular biology of diabetes as well as active support from a broad network of collaborators in the field of cell metabolism. The proposed research project has the scientific, structural and institutional support to bring new knowledge on T cell metabolic demand and functional properties in human obesity and lead to the discovery of new pathways involved in the induction of insulin-resistance, ultimately fostering advances in the field of Immunometabolism as well as the applicant’s career development.

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The information about "FIT-THE-FAT" are provided by the European Opendata Portal: CORDIS opendata.

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