FNS-4-NAMOSAT
Development of fluorescence nanospectroscopy to elucidate the roles of nanoscale molecular segregation in the activation of T-cells
Total Cost €
0EC-Contrib. €
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Project "FNS-4-NAMOSAT" data sheet
The following table provides information about the project.
| Coordinator |
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
Organization address contact info |
| Coordinator Country | United Kingdom [UK] |
| Total cost | 195˙454 € |
| EC max contribution | 195˙454 € (100%) |
| Programme |
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility) |
| Code Call | H2020-MSCA-IF-2015 |
| Funding Scheme | MSCA-IF-EF-ST |
| Starting year | 2016 |
| Duration (year-month-day) | from 2016-10-01 to 2018-09-30 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD | UK (OXFORD) | coordinator | 195˙454.00 |
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Project objective
BACKGROUND Nanoscale protein and lipid heterogeneities, e.g. lipid rafts, have been detected in numerous membrane-related cellular processes, including the initiation of the immune response upon T-cell activation. However, the interplay of protein and lipid segregation remains unclear.
PROBLEM Super-resolution fluorescence microscopy can localize such supramolecular structures, but reveals little information on their identity. In contrast, (micro)spectroscopies with environment-sensitive probes can identify local molecular properties, but lack the appropriate spatial resolution for their localization.
AIM The main research goal of the Action is to establish an original method with suitable resolution and sensitivity to improve our understanding of lipid reorganization during the activation of T-cells.
SOLUTION We will develop fluorescence nanospectroscopy (FNS) by combining STED microscopy, spectral detection, and environment-sensitive probes, to achieve the sensitivity to local molecular properties with nanoscale spatial resolution.
IMPACT Besides new insights into molecular mechanisms of immunity, FNS will importantly complement the available methods by probing local molecular order, facilitating FRET measurements, super-resolved spectral imaging etc. It will enable further advances in numerous fields of molecular and cell biology where membrane proteins and lipids act in a precisely coordinated manner.
TRAINING The Researcher will be enrolled in the world-leading environment in the fields of STED microscopy, membrane structure and dynamics, and immunology. The acquired deep knowledge on the subjects of research, gained solid experimental and leadership skills from the Supervisor, invaluable experience from a cross-sectoral visit in the collaborating company, as well as his integration into the network within the scientific communities of planned multidisciplinary research activities, will decisively boost his future career as an independent life scientist.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2017 |
Erdinc Sezgin, Falk Schneider, Victoria Zilles, Iztok UrbanÄiÄ, Esther Garcia, Dominic Waithe, Andrey S. Klymchenko, Christian Eggeling Polarity-Sensitive Probes for Superresolution Stimulated Emission Depletion Microscopy published pages: 1321-1330, ISSN: 0006-3495, DOI: 10.1016/j.bpj.2017.06.050 |
Biophysical Journal 113/6 | 2019-04-18 |
| 2018 |
Iztok UrbanÄiÄ, Juliane Brun, Dilip Shrestha, Dominic Waithe, Christian Eggeling, Jakub Chojnacki Lipid Composition but not Curvature Is the Determinant Factor for the Low Molecular Mobility Observed on the Membrane of Virus-Like Vesicles published pages: 415, ISSN: 1999-4915, DOI: 10.3390/v10080415 |
Viruses 10/8 | 2019-04-18 |
| 2018 |
Ana Mafalda Santos, Aleks Ponjavic, Marco Fritzsche, Ricardo A. Fernandes, Jorge Bernardino de la Serna, Martin J. Wilcock, Falk Schneider, Iztok UrbanÄiÄ, James McColl, Consuelo Anzilotti, Kristina A. Ganzinger, Meike Aßmann, David Depoil, Richard J. Cornall, Michael L. Dustin, David Klenerman, Simon J. Davis, Christian Eggeling, Steven F. Lee Capturing resting T cells: the perils of PLL published pages: 203-205, ISSN: 1529-2908, DOI: 10.1038/s41590-018-0048-8 |
Nature Immunology 19/3 | 2019-04-18 |
| 2018 |
Iztok UrbanÄiÄ, Maja Garvas, BoÅ¡tjan Kokot, Hana Majaron, Polona Umek, Hilary Cassidy, Miha Å karabot, Falk Schneider, Silvia Galiani, Zoran Arsov, Tilen Koklic, David Matallanas, Miran ÄŒeh, Igor MuÅ¡eviÄ, Christian Eggeling, Janez Å trancar Nanoparticles Can Wrap Epithelial Cell Membranes and Relocate Them Across the Epithelial Cell Layer published pages: 5294-5305, ISSN: 1530-6984, DOI: 10.1021/acs.nanolett.8b02291 |
Nano Letters 18/8 | 2019-04-18 |
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