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2O2ACTIVATION SIGNED

Development of Direct Dehydrogenative Couplings mediated by Dioxygen

Total Cost €

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EC-Contrib. €

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Partnership

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 2O2ACTIVATION project word cloud

Explore the words cloud of the 2O2ACTIVATION project. It provides you a very rough idea of what is the project "2O2ACTIVATION" about.

chemical    costly    environment    oxidative    ing    reactions    water    techniques    lasting    decrease    building    inactivated    event    pace    preserving    commodities    coupling    functionalization    sustainability    sustainable    catalysts    readily    poorly    direct    propene    hypervalent    efficient    undermining    constitutes    functionalizations    blocks    oxidant    chemistry    thereby    bypass    catalyzed    dehydrogenative    analogues    metalating    consequently    catalysis    lines    2o2activation    clear    terminal    rely    bonds    exponential    easily    synthesis    technologies    regulations    routes    last    appeals    shortcut    synthetic    dramatically    metal    oxidants    efficiency    scalable    15    certain    industry    seriously    forming    utilizing    activation    extremely    moderate    breakthroughs    divided    sole    halide    chemicals    pioneer    restrictions    atom    philosophy    waste    motive    novels    usually    o2    bond    propenoids    thermodynamically    organic    couplings    ultra    unprotected    reactivity    cross   

Project "2O2ACTIVATION" data sheet

The following table provides information about the project.

Coordinator
RHEINISCH-WESTFAELISCHE TECHNISCHE HOCHSCHULE AACHEN 

Organization address
address: TEMPLERGRABEN 55
city: AACHEN
postcode: 52062
website: www.rwth-aachen.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙489˙822 €
 EC max contribution 1˙489˙822 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-STG
 Funding Scheme ERC-STG
 Starting year 2017
 Duration (year-month-day) from 2017-03-01   to  2022-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    RHEINISCH-WESTFAELISCHE TECHNISCHE HOCHSCHULE AACHEN DE (AACHEN) coordinator 1˙080˙832.00
2    TECHNISCHE UNIVERSITAET KAISERSLAUTERN DE (KAISERSLAUTERN) participant 408˙989.00

Map

 Project objective

The field of C-H bond activation has evolved at an exponential pace in the last 15 years. What appeals most in those novel synthetic techniques is clear: they bypass the pre-activation steps usually required in traditional cross-coupling chemistry by directly metalating C-H bonds. Many C-H bond functionalizations today however, rely on poorly atom and step efficient oxidants, leading to significant and costly chemical waste, thereby seriously undermining the overall sustainability of those methods. As restrictions in sustainability regulations will further increase, and the cost of certain chemical commodities will rise, atom efficiency in organic synthesis remains a top priority for research.

The aim of 2O2ACTIVATION is to develop novel technologies utilizing O2 as sole terminal oxidant in order to allow useful, extremely sustainable, thermodynamically challenging, dehydrogenative C-N and C-O bond forming coupling reactions. However, the moderate reactivity of O2 towards many catalysts constitutes a major challenge. 2O2ACTIVATION will pioneer the design of new catalysts based on the ultra-simple propene motive, capable of direct activation of O2 for C-H activation based cross-couplings. The project is divided into 3 major lines: O2 activation using propene and its analogues (propenoids), 1) without metal or halide, 2) with hypervalent halide catalysis, 3) with metal catalyzed C-H activation. The philosophy of 2O2ACTIVATION is to focus C-H functionalization method development on the oxidative event.

Consequently, 2O2ACTIVATION breakthroughs will dramatically shortcut synthetic routes through the use of inactivated, unprotected, and readily available building blocks; and thus should be easily scalable. This will lead to a strong decrease in the costs related to the production of many essential chemicals, while preserving the environment (water as terminal by-product). The resulting novels coupling methods will thus have a lasting impact on the chemical industry.

 Publications

year authors and title journal last update
List of publications.
2019 Christian K. Rank, Alexander W. Jones, Tatjana Wall, Patrick Di Martino-Fumo, Sarah Schröck, Markus Gerhards, Frederic W. Patureau
An intermolecular C–H oxidizing strategy to access highly fused carbazole skeletons from simple naphthylamines
published pages: , ISSN: 1359-7345, DOI: 10.1039/c9cc05240b
Chemical Communications 2019-11-07
2019 Congjun Yu, Frederic W. Patureau
Regioselective Oxidative Arylation of Fluorophenols
published pages: , ISSN: 1433-7851, DOI: 10.1002/anie.201910352
Angewandte Chemie International Edition 2019-11-07
2019 Frederic W. Patureau
The Phenol-Phenothiazine Coupling: an Oxidative Click Concept
published pages: , ISSN: 1867-3880, DOI: 10.1002/cctc.201900152
ChemCatChem 2019-10-08
2018 Annika Bernhardt, Harald Kelm, Frederic W. Patureau
The Strong β−CF 3 Shielding Effect in Hexafluoroisopropanol and 100 Other Organic Solvents Revisited with 17 O NMR Spectroscopy
published pages: 1547-1551, ISSN: 1867-3880, DOI: 10.1002/cctc.201701721
ChemCatChem 10/7 2019-06-13
2018 Rongwei Jin, Christina L. Bub, Frederic W. Patureau
Phenothiazinimides: Atom-Efficient Electrophilic Amination Reagents
published pages: 2884-2887, ISSN: 1523-7060, DOI: 10.1021/acs.orglett.8b00914
Organic Letters 20/10 2019-06-13
2017 A. Malekafzali, K. Malinovska, F. W. Patureau
The cumene/O 2 system: a very simple tool for the radical chain oxidation of some functional groups
published pages: 6981-6985, ISSN: 1144-0546, DOI: 10.1039/C7NJ01666B
New Journal of Chemistry 41/15 2019-06-13
2018 Alexander W. Jones, Christian K. Rank, Yanik Becker, Christian Malchau, Ignacio Funes-Ardoiz, Feliu Maseras, Frederic W. Patureau
Accelerated Ru-Cu Trinuclear Cooperative C−H Bond Functionalization of Carbazoles: A Kinetic and Computational Investigation
published pages: , ISSN: 0947-6539, DOI: 10.1002/chem.201802886
Chemistry - A European Journal 2019-06-13
2018 Monalisa Goswami, Alexander Konkel, Maryam Rahimi, Marie-Laure Louillat-Habermeyer, Harald Kelm, Rongwei Jin, Bas de Bruin, Frederic W. Patureau
Mechanism of the Dehydrogenative Phenothiazination of Phenols
published pages: 11936-11943, ISSN: 0947-6539, DOI: 10.1002/chem.201800730
Chemistry - A European Journal 24/46 2019-06-13
2018 Congjun Yu, Frederic W. Patureau
Cu-Catalyzed Cross-Dehydrogenative ortho -Aminomethylation of Phenols
published pages: 11807-11811, ISSN: 1433-7851, DOI: 10.1002/anie.201804829
Angewandte Chemie International Edition 57/36 2019-06-13

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