Explore the words cloud of the SLaMM project. It provides you a very rough idea of what is the project "SLaMM" about.
The following table provides information about the project.
FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA
|Coordinator Country||Italy [IT]|
|Total cost||1˙499˙997 €|
|EC max contribution||1˙499˙997 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2017-03-01 to 2022-02-28|
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|1||FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA||IT (GENOVA)||coordinator||1˙499˙997.00|
Central nervous system (CNS) tumors are an important cause of morbidity and mortality worldwide. Among them, glioblastoma multiforme (GBM) is the most aggressive and lethal, characterized by extensive infiltration into the brain parenchyma. Under the standard treatment protocols, GBM patients can expect a median survival of 14.6 months, while less than 5% of patients live longer than 5 years. This poor prognosis is due to several factors, including the highly aggressive and infiltrative nature of GBM, resulting in incomplete resection, and the limited delivery of therapeutics across the blood-brain-barrier (BBB). The present project aims at addressing these therapeutic challenges by proposing a nanotechnology-based approach for the treatment of GBM, focused on the selective uptake of drug-loaded multifunctional magnetic solid lipid nanoparticles (SLNs). An external magnetic guidance will help the SLN accumulation on the cerebral endothelium, where, owing to their lipid nature, they will be allowed to enter the CNS. Here, appropriate surface ligands will drive their internalization inside cancer cells. The chemotherapeutic payload will undergo release, allowing a targeted pharmaceutical treatment that will be combined to hyperthermia upon appropriate radiofrequency application. A synergic attack against GBM will thus be performed, consisting of a chemical attack thanks to the drug, and a physical attack thanks to hyperthermia, that will dramatically enhance the possibilities of therapeutic success. By demonstrating the effectiveness of the platform to cross the BBB and to support tumor regression, a huge impact on human healthcare is envisioned. Moreover, further outcomes of this project are expected by considering the development of nanotechnology-based, multi-functional solutions that can easily be adapted to many other high-impact diseases, in particular at the brain level, where BBB crossing poses a crucial obstacle to many therapeutic approaches.
|year||authors and title||journal||last update|
Christos Tapeinos, Attilio Marino, Gianni Ciofani
Editorial: Advanced Theranostic Nanomedicine in Oncology
published pages: , ISSN: 2296-4185, DOI: 10.3389/fbioe.2020.00142
|Frontiers in Bioengineering and Biotechnology 8||2020-03-13|
Carlotta Pucci, Chiara Martinelli, Gianni Ciofani
What does the future hold for chemotherapy with the use of lipid-based nanocarriers?
published pages: 81-84, ISSN: 1479-6694, DOI: 10.2217/fon-2019-0767
|Future Oncology 16/5||2020-03-13|
Andrea Degl\'Innocenti, Nicoletta di Leo, Gianni Ciofani
Genetic Hallmarks and Heterogeneity of Glioblastoma in the Singleâ€Cell Omics Era
published pages: 1900152, ISSN: 2366-3987, DOI: 10.1002/adtp.201900152
|Advanced Therapeutics 3/1||2020-01-30|
Attilio Marino, Alice Camponovo, Andrea Degl\'Innocenti, Martina Bartolucci, Christos Tapeinos, Chiara Martinelli, Daniele De Pasquale, Francesca Santoro, Valentina Mollo, Satoshi Arai, Madoka Suzuki, Yoshie Harada, Andrea Petretto, Gianni Ciofani
Multifunctional temozolomide-loaded lipid superparamagnetic nanovectors: dual targeting and disintegration of glioblastoma spheroids by synergic chemotherapy and hyperthermia treatment
published pages: 21227-21248, ISSN: 2040-3364, DOI: 10.1039/c9nr07976a
Carlotta Pucci, Chiara Martinelli, Gianni Ciofani
Innovative approaches for cancer treatment: current perspectives and new challenges
published pages: 961, ISSN: 1754-6605, DOI: 10.3332/ecancer.2019.961
Attilio Marino, Omar Tricinci, Matteo Battaglini, Carlo Filippeschi, Virgilio Mattoli, Edoardo Sinibaldi, Gianni Ciofani
A 3D Real-Scale, Biomimetic, and Biohybrid Model of the Blood-Brain Barrier Fabricated through Two-Photon Lithography
published pages: 1702959, ISSN: 1613-6810, DOI: 10.1002/smll.201702959
Giada Graziana Genchi, Attilio Marino, Christos Tapeinos, Gianni Ciofani
Smart Materials Meet Multifunctional Biomedical Devices: Current and Prospective Implications for Nanomedicine
published pages: 8, ISSN: 2296-4185, DOI: 10.3389/fbioe.2017.00080
|Frontiers in Bioengineering and Biotechnology 5||2019-07-25|
Agostina Grillone, Gianni Ciofani
Magnetic Nanotransducers in Biomedicine
published pages: 16109-16114, ISSN: 0947-6539, DOI: 10.1002/chem.201703660
|Chemistry - A European Journal 23/64||2019-07-25|
Chiara Martinelli, Carlotta Pucci, Gianni Ciofani
Nanostructured carriers as innovative tools for cancer diagnosis and therapy
published pages: 11502, ISSN: 2473-2877, DOI: 10.1063/1.5079943
|APL Bioengineering 3/1||2019-07-25|
Agostina Grillone, Matteo Battaglini, Stefania Moscato, Letizia Mattii, CÃ©sar de JuliÃ¡n FernÃ¡ndez, Alice Scarpellini, Mario Giorgi, Edoardo Sinibaldi, Gianni Ciofani
Nutlin-loaded magnetic solid lipid nanoparticles for targeted glioblastoma treatment
published pages: 727-752, ISSN: 1743-5889, DOI: 10.2217/nnm-2018-0436
Attilio Marino, Enrico Almici, Simone Migliorin, Christos Tapeinos, Matteo Battaglini, Valentina Cappello, Marco Marchetti, Giuseppe de Vito, Riccardo Cicchi, Francesco Saverio Pavone, Gianni Ciofani
Piezoelectric barium titanate nanostimulators for the treatment of glioblastoma multiforme
published pages: 449-461, ISSN: 0021-9797, DOI: 10.1016/j.jcis.2018.12.014
|Journal of Colloid and Interface Science 538||2019-07-25|
Christos Tapeinos, Attilio Marino, Matteo Battaglini, Simone Migliorin, Rosaria Brescia, Alice Scarpellini, CÃ©sar De JuliÃ¡n FernÃ¡ndez, Mirko Prato, Filippo Drago, Gianni Ciofani
Stimuli-responsive lipid-based magnetic nanovectors increase apoptosis in glioblastoma cells through synergic intracellular hyperthermia and chemotherapy
published pages: 72-88, ISSN: 2040-3364, DOI: 10.1039/C8NR05520C
Christos Tapeinos, Matteo Battaglini, Gianni Ciofani
Advances in the design of solid lipid nanoparticles and nanostructured lipid carriers for targeting brain diseases
published pages: 306-332, ISSN: 0168-3659, DOI: 10.1016/j.jconrel.2017.08.033
|Journal of Controlled Release 264||2019-07-25|
Christos Tapeinos, Francesca Tomatis, Matteo Battaglini, Aitor LarraÃ±aga, Attilio Marino, Iker Aguirrezabal Telleria, Makis Angelakeris, Doriana Debellis, Filippo Drago, Francesca Brero, Paolo Arosio, Alessandro Lascialfari, Andrea Petretto, Edoardo Sinibaldi, Gianni Ciofani
Cell Membraneâ€Coated Magnetic Nanocubes with a Homotypic Targeting Ability Increase Intracellular Temperature due to ROS Scavenging and Act as a Versatile Theranostic System for Glioblastoma Multiforme
published pages: 1900612, ISSN: 2192-2640, DOI: 10.1002/adhm.201900612
|Advanced Healthcare Materials||2019-08-29|
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