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SLaMM SIGNED

Magnetic Solid Lipid Nanoparticles as a Multifunctional Platform against Glioblastoma Multiforme

Total Cost €

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EC-Contrib. €

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Partnership

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 SLaMM project word cloud

Explore the words cloud of the SLaMM project. It provides you a very rough idea of what is the project "SLaMM" about.

tumor    therapeutics    live    functional    envisioned    aggressive    nervous    poses    huge    platform    cross    longer    magnetic    poor    infiltration    accumulation    drug    regression    parenchyma    possibilities    effectiveness    gbm    multiforme    owing    chemical    incomplete    hyperthermia    physical    drive    14    inside    months    brain    dramatically    infiltrative    treatment    diseases    healthcare    cancer    outcomes    pharmaceutical    median    solid    demonstrating    nature    mortality    thanks    slns    multifunctional    cells    central    obstacle    resection    surface    protocols    radiofrequency    external    patients    combined    blood    survival    enter    endothelium    internalization    selective    lethal    attack    ing    cns    synergic    easily    morbidity    payload    barrier    ligands    prognosis    crossing    limited    loaded    solutions    consisting    glioblastoma    considering    chemotherapeutic    nanoparticles    release    cerebral    proposing    guidance    nanotechnology    appropriate    therapeutic    undergo       human    bbb    lipid    allowed    extensive    worldwide    standard    performed    tumors    sln   

Project "SLaMM" data sheet

The following table provides information about the project.

Coordinator
FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA 

Organization address
address: VIA MOREGO 30
city: GENOVA
postcode: 16163
website: www.iit.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 1˙499˙997 €
 EC max contribution 1˙499˙997 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-STG
 Funding Scheme ERC-STG
 Starting year 2017
 Duration (year-month-day) from 2017-03-01   to  2022-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA IT (GENOVA) coordinator 1˙499˙997.00

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 Project objective

Central nervous system (CNS) tumors are an important cause of morbidity and mortality worldwide. Among them, glioblastoma multiforme (GBM) is the most aggressive and lethal, characterized by extensive infiltration into the brain parenchyma. Under the standard treatment protocols, GBM patients can expect a median survival of 14.6 months, while less than 5% of patients live longer than 5 years. This poor prognosis is due to several factors, including the highly aggressive and infiltrative nature of GBM, resulting in incomplete resection, and the limited delivery of therapeutics across the blood-brain-barrier (BBB). The present project aims at addressing these therapeutic challenges by proposing a nanotechnology-based approach for the treatment of GBM, focused on the selective uptake of drug-loaded multifunctional magnetic solid lipid nanoparticles (SLNs). An external magnetic guidance will help the SLN accumulation on the cerebral endothelium, where, owing to their lipid nature, they will be allowed to enter the CNS. Here, appropriate surface ligands will drive their internalization inside cancer cells. The chemotherapeutic payload will undergo release, allowing a targeted pharmaceutical treatment that will be combined to hyperthermia upon appropriate radiofrequency application. A synergic attack against GBM will thus be performed, consisting of a chemical attack thanks to the drug, and a physical attack thanks to hyperthermia, that will dramatically enhance the possibilities of therapeutic success. By demonstrating the effectiveness of the platform to cross the BBB and to support tumor regression, a huge impact on human healthcare is envisioned. Moreover, further outcomes of this project are expected by considering the development of nanotechnology-based, multi-functional solutions that can easily be adapted to many other high-impact diseases, in particular at the brain level, where BBB crossing poses a crucial obstacle to many therapeutic approaches.

 Publications

year authors and title journal last update
List of publications.
2020 Christos Tapeinos, Attilio Marino, Gianni Ciofani
Editorial: Advanced Theranostic Nanomedicine in Oncology
published pages: , ISSN: 2296-4185, DOI: 10.3389/fbioe.2020.00142
Frontiers in Bioengineering and Biotechnology 8 2020-03-13
2020 Carlotta Pucci, Chiara Martinelli, Gianni Ciofani
What does the future hold for chemotherapy with the use of lipid-based nanocarriers?
published pages: 81-84, ISSN: 1479-6694, DOI: 10.2217/fon-2019-0767
Future Oncology 16/5 2020-03-13
2019 Andrea Degl\'Innocenti, Nicoletta di Leo, Gianni Ciofani
Genetic Hallmarks and Heterogeneity of Glioblastoma in the Single‐Cell Omics Era
published pages: 1900152, ISSN: 2366-3987, DOI: 10.1002/adtp.201900152
Advanced Therapeutics 3/1 2020-01-30
2019 Attilio Marino, Alice Camponovo, Andrea Degl\'Innocenti, Martina Bartolucci, Christos Tapeinos, Chiara Martinelli, Daniele De Pasquale, Francesca Santoro, Valentina Mollo, Satoshi Arai, Madoka Suzuki, Yoshie Harada, Andrea Petretto, Gianni Ciofani
Multifunctional temozolomide-loaded lipid superparamagnetic nanovectors: dual targeting and disintegration of glioblastoma spheroids by synergic chemotherapy and hyperthermia treatment
published pages: 21227-21248, ISSN: 2040-3364, DOI: 10.1039/c9nr07976a
Nanoscale 11/44 2019-12-16
2019 Carlotta Pucci, Chiara Martinelli, Gianni Ciofani
Innovative approaches for cancer treatment: current perspectives and new challenges
published pages: 961, ISSN: 1754-6605, DOI: 10.3332/ecancer.2019.961
ecancermedicalscience 13 2019-10-01
2018 Attilio Marino, Omar Tricinci, Matteo Battaglini, Carlo Filippeschi, Virgilio Mattoli, Edoardo Sinibaldi, Gianni Ciofani
A 3D Real-Scale, Biomimetic, and Biohybrid Model of the Blood-Brain Barrier Fabricated through Two-Photon Lithography
published pages: 1702959, ISSN: 1613-6810, DOI: 10.1002/smll.201702959
Small 14/6 2019-07-25
2017 Giada Graziana Genchi, Attilio Marino, Christos Tapeinos, Gianni Ciofani
Smart Materials Meet Multifunctional Biomedical Devices: Current and Prospective Implications for Nanomedicine
published pages: 8, ISSN: 2296-4185, DOI: 10.3389/fbioe.2017.00080
Frontiers in Bioengineering and Biotechnology 5 2019-07-25
2017 Agostina Grillone, Gianni Ciofani
Magnetic Nanotransducers in Biomedicine
published pages: 16109-16114, ISSN: 0947-6539, DOI: 10.1002/chem.201703660
Chemistry - A European Journal 23/64 2019-07-25
2019 Chiara Martinelli, Carlotta Pucci, Gianni Ciofani
Nanostructured carriers as innovative tools for cancer diagnosis and therapy
published pages: 11502, ISSN: 2473-2877, DOI: 10.1063/1.5079943
APL Bioengineering 3/1 2019-07-25
2019 Agostina Grillone, Matteo Battaglini, Stefania Moscato, Letizia Mattii, César de Julián Fernández, Alice Scarpellini, Mario Giorgi, Edoardo Sinibaldi, Gianni Ciofani
Nutlin-loaded magnetic solid lipid nanoparticles for targeted glioblastoma treatment
published pages: 727-752, ISSN: 1743-5889, DOI: 10.2217/nnm-2018-0436
Nanomedicine 14/6 2019-07-25
2019 Attilio Marino, Enrico Almici, Simone Migliorin, Christos Tapeinos, Matteo Battaglini, Valentina Cappello, Marco Marchetti, Giuseppe de Vito, Riccardo Cicchi, Francesco Saverio Pavone, Gianni Ciofani
Piezoelectric barium titanate nanostimulators for the treatment of glioblastoma multiforme
published pages: 449-461, ISSN: 0021-9797, DOI: 10.1016/j.jcis.2018.12.014
Journal of Colloid and Interface Science 538 2019-07-25
2019 Christos Tapeinos, Attilio Marino, Matteo Battaglini, Simone Migliorin, Rosaria Brescia, Alice Scarpellini, César De Julián Fernández, Mirko Prato, Filippo Drago, Gianni Ciofani
Stimuli-responsive lipid-based magnetic nanovectors increase apoptosis in glioblastoma cells through synergic intracellular hyperthermia and chemotherapy
published pages: 72-88, ISSN: 2040-3364, DOI: 10.1039/C8NR05520C
Nanoscale 11/1 2019-07-25
2017 Christos Tapeinos, Matteo Battaglini, Gianni Ciofani
Advances in the design of solid lipid nanoparticles and nanostructured lipid carriers for targeting brain diseases
published pages: 306-332, ISSN: 0168-3659, DOI: 10.1016/j.jconrel.2017.08.033
Journal of Controlled Release 264 2019-07-25
2019 Christos Tapeinos, Francesca Tomatis, Matteo Battaglini, Aitor Larrañaga, Attilio Marino, Iker Aguirrezabal Telleria, Makis Angelakeris, Doriana Debellis, Filippo Drago, Francesca Brero, Paolo Arosio, Alessandro Lascialfari, Andrea Petretto, Edoardo Sinibaldi, Gianni Ciofani
Cell Membrane‐Coated Magnetic Nanocubes with a Homotypic Targeting Ability Increase Intracellular Temperature due to ROS Scavenging and Act as a Versatile Theranostic System for Glioblastoma Multiforme
published pages: 1900612, ISSN: 2192-2640, DOI: 10.1002/adhm.201900612
Advanced Healthcare Materials 2019-08-29

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