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Magnetic Solid Lipid Nanoparticles as a Multifunctional Platform against Glioblastoma Multiforme

Total Cost €


EC-Contrib. €






 SLaMM project word cloud

Explore the words cloud of the SLaMM project. It provides you a very rough idea of what is the project "SLaMM" about.

ing       attack    outcomes    barrier    nanoparticles    surface    therapeutic    synergic    performed    payload    envisioned    external    internalization    possibilities    hyperthermia    extensive    slns    proposing    thanks    multiforme    poor    chemical    prognosis    guidance    mortality    effectiveness    bbb    allowed    inside    drive    blood    solutions    platform    crossing    undergo    cancer    radiofrequency    magnetic    tumors    dramatically    nanotechnology    owing    morbidity    longer    healthcare    live    pharmaceutical    drug    standard    selective    poses    incomplete    tumor    glioblastoma    combined    human    treatment    considering    lipid    accumulation    demonstrating    cerebral    survival    huge    aggressive    nature    worldwide    therapeutics    regression    cns    central    enter    infiltration    lethal    resection    infiltrative    functional    parenchyma    diseases    appropriate    protocols    cells    gbm    median    chemotherapeutic    easily    obstacle    ligands    multifunctional    loaded    sln    solid    cross    consisting    patients    endothelium    limited    brain    14    months    nervous    release    physical   

Project "SLaMM" data sheet

The following table provides information about the project.


Organization address
address: VIA MOREGO 30
city: GENOVA
postcode: 16163

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 1˙499˙997 €
 EC max contribution 1˙499˙997 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-STG
 Funding Scheme ERC-STG
 Starting year 2017
 Duration (year-month-day) from 2017-03-01   to  2022-02-28


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Central nervous system (CNS) tumors are an important cause of morbidity and mortality worldwide. Among them, glioblastoma multiforme (GBM) is the most aggressive and lethal, characterized by extensive infiltration into the brain parenchyma. Under the standard treatment protocols, GBM patients can expect a median survival of 14.6 months, while less than 5% of patients live longer than 5 years. This poor prognosis is due to several factors, including the highly aggressive and infiltrative nature of GBM, resulting in incomplete resection, and the limited delivery of therapeutics across the blood-brain-barrier (BBB). The present project aims at addressing these therapeutic challenges by proposing a nanotechnology-based approach for the treatment of GBM, focused on the selective uptake of drug-loaded multifunctional magnetic solid lipid nanoparticles (SLNs). An external magnetic guidance will help the SLN accumulation on the cerebral endothelium, where, owing to their lipid nature, they will be allowed to enter the CNS. Here, appropriate surface ligands will drive their internalization inside cancer cells. The chemotherapeutic payload will undergo release, allowing a targeted pharmaceutical treatment that will be combined to hyperthermia upon appropriate radiofrequency application. A synergic attack against GBM will thus be performed, consisting of a chemical attack thanks to the drug, and a physical attack thanks to hyperthermia, that will dramatically enhance the possibilities of therapeutic success. By demonstrating the effectiveness of the platform to cross the BBB and to support tumor regression, a huge impact on human healthcare is envisioned. Moreover, further outcomes of this project are expected by considering the development of nanotechnology-based, multi-functional solutions that can easily be adapted to many other high-impact diseases, in particular at the brain level, where BBB crossing poses a crucial obstacle to many therapeutic approaches.


year authors and title journal last update
List of publications.
2020 Christos Tapeinos, Attilio Marino, Gianni Ciofani
Editorial: Advanced Theranostic Nanomedicine in Oncology
published pages: , ISSN: 2296-4185, DOI: 10.3389/fbioe.2020.00142
Frontiers in Bioengineering and Biotechnology 8 2020-03-13
2020 Carlotta Pucci, Chiara Martinelli, Gianni Ciofani
What does the future hold for chemotherapy with the use of lipid-based nanocarriers?
published pages: 81-84, ISSN: 1479-6694, DOI: 10.2217/fon-2019-0767
Future Oncology 16/5 2020-03-13
2019 Andrea Degl\'Innocenti, Nicoletta di Leo, Gianni Ciofani
Genetic Hallmarks and Heterogeneity of Glioblastoma in the Single‐Cell Omics Era
published pages: 1900152, ISSN: 2366-3987, DOI: 10.1002/adtp.201900152
Advanced Therapeutics 3/1 2020-01-30
2019 Attilio Marino, Alice Camponovo, Andrea Degl\'Innocenti, Martina Bartolucci, Christos Tapeinos, Chiara Martinelli, Daniele De Pasquale, Francesca Santoro, Valentina Mollo, Satoshi Arai, Madoka Suzuki, Yoshie Harada, Andrea Petretto, Gianni Ciofani
Multifunctional temozolomide-loaded lipid superparamagnetic nanovectors: dual targeting and disintegration of glioblastoma spheroids by synergic chemotherapy and hyperthermia treatment
published pages: 21227-21248, ISSN: 2040-3364, DOI: 10.1039/c9nr07976a
Nanoscale 11/44 2019-12-16
2019 Carlotta Pucci, Chiara Martinelli, Gianni Ciofani
Innovative approaches for cancer treatment: current perspectives and new challenges
published pages: 961, ISSN: 1754-6605, DOI: 10.3332/ecancer.2019.961
ecancermedicalscience 13 2019-10-01
2018 Attilio Marino, Omar Tricinci, Matteo Battaglini, Carlo Filippeschi, Virgilio Mattoli, Edoardo Sinibaldi, Gianni Ciofani
A 3D Real-Scale, Biomimetic, and Biohybrid Model of the Blood-Brain Barrier Fabricated through Two-Photon Lithography
published pages: 1702959, ISSN: 1613-6810, DOI: 10.1002/smll.201702959
Small 14/6 2019-07-25
2017 Giada Graziana Genchi, Attilio Marino, Christos Tapeinos, Gianni Ciofani
Smart Materials Meet Multifunctional Biomedical Devices: Current and Prospective Implications for Nanomedicine
published pages: 8, ISSN: 2296-4185, DOI: 10.3389/fbioe.2017.00080
Frontiers in Bioengineering and Biotechnology 5 2019-07-25
2017 Agostina Grillone, Gianni Ciofani
Magnetic Nanotransducers in Biomedicine
published pages: 16109-16114, ISSN: 0947-6539, DOI: 10.1002/chem.201703660
Chemistry - A European Journal 23/64 2019-07-25
2019 Chiara Martinelli, Carlotta Pucci, Gianni Ciofani
Nanostructured carriers as innovative tools for cancer diagnosis and therapy
published pages: 11502, ISSN: 2473-2877, DOI: 10.1063/1.5079943
APL Bioengineering 3/1 2019-07-25
2019 Agostina Grillone, Matteo Battaglini, Stefania Moscato, Letizia Mattii, César de Julián Fernández, Alice Scarpellini, Mario Giorgi, Edoardo Sinibaldi, Gianni Ciofani
Nutlin-loaded magnetic solid lipid nanoparticles for targeted glioblastoma treatment
published pages: 727-752, ISSN: 1743-5889, DOI: 10.2217/nnm-2018-0436
Nanomedicine 14/6 2019-07-25
2019 Attilio Marino, Enrico Almici, Simone Migliorin, Christos Tapeinos, Matteo Battaglini, Valentina Cappello, Marco Marchetti, Giuseppe de Vito, Riccardo Cicchi, Francesco Saverio Pavone, Gianni Ciofani
Piezoelectric barium titanate nanostimulators for the treatment of glioblastoma multiforme
published pages: 449-461, ISSN: 0021-9797, DOI: 10.1016/j.jcis.2018.12.014
Journal of Colloid and Interface Science 538 2019-07-25
2019 Christos Tapeinos, Attilio Marino, Matteo Battaglini, Simone Migliorin, Rosaria Brescia, Alice Scarpellini, César De Julián Fernández, Mirko Prato, Filippo Drago, Gianni Ciofani
Stimuli-responsive lipid-based magnetic nanovectors increase apoptosis in glioblastoma cells through synergic intracellular hyperthermia and chemotherapy
published pages: 72-88, ISSN: 2040-3364, DOI: 10.1039/C8NR05520C
Nanoscale 11/1 2019-07-25
2017 Christos Tapeinos, Matteo Battaglini, Gianni Ciofani
Advances in the design of solid lipid nanoparticles and nanostructured lipid carriers for targeting brain diseases
published pages: 306-332, ISSN: 0168-3659, DOI: 10.1016/j.jconrel.2017.08.033
Journal of Controlled Release 264 2019-07-25
2019 Christos Tapeinos, Francesca Tomatis, Matteo Battaglini, Aitor Larrañaga, Attilio Marino, Iker Aguirrezabal Telleria, Makis Angelakeris, Doriana Debellis, Filippo Drago, Francesca Brero, Paolo Arosio, Alessandro Lascialfari, Andrea Petretto, Edoardo Sinibaldi, Gianni Ciofani
Cell Membrane‐Coated Magnetic Nanocubes with a Homotypic Targeting Ability Increase Intracellular Temperature due to ROS Scavenging and Act as a Versatile Theranostic System for Glioblastoma Multiforme
published pages: 1900612, ISSN: 2192-2640, DOI: 10.1002/adhm.201900612
Advanced Healthcare Materials 2019-08-29

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