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COAGULANT SIGNED

CK2-dependent cytoskeletal regulation and molecular signaling of Neutrophil Extracellular Trap (NET) formation

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 COAGULANT project word cloud

Explore the words cloud of the COAGULANT project. It provides you a very rough idea of what is the project "COAGULANT" about.

tubulin    neutrophils    cardiovascular    subset    almost    thereby    molecular    decondensed    thrombo    thrombosis    activation    envelope    abundant    chromatin    50    suitable    trap    acute    regulators    histones    myocardial    cardiac    microtubules    nothing    integrity    prerequisite    personalized    upstream    primary    identification    filaments    microtubule    hemostasis    incorporated    mechanisms    last    filament    arterial    inducer    elastases    ck2    thrombotic    care    variety    effect    release    infarction    crucially    nuclear    inflammatory    kinase    stability    rearrangements    treatment    immune    beside    critically    ing    underlying    leukocytes    ubiquitous    occlusive    celly    cells    casein    enormous    stroke    maintaining    union    fibrosis    structures    morbidity    cytoskeleton    vivo    atherothrombosis    platelets    diseases    neutrophil    events    damage    mainly    molecule    tissue    ischemic    nets    play    disability    causing    occlusions    intermediate    pro    acknowledged    health    dynamics    net    extracellular    hitherto    belong   

Project "COAGULANT" data sheet

The following table provides information about the project.

Coordinator
EBERHARD KARLS UNIVERSITAET TUEBINGEN 

Organization address
address: GESCHWISTER-SCHOLL-PLATZ
city: TUEBINGEN
postcode: 72074
website: www.uni-tuebingen.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 239˙860 €
 EC max contribution 239˙860 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-GF
 Starting year 2018
 Duration (year-month-day) from 2018-09-01   to  2021-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    EBERHARD KARLS UNIVERSITAET TUEBINGEN DE (TUEBINGEN) coordinator 239˙860.00
2    CHILDREN'S HOSPITAL CORPORATION US (BOSTON) partner 0.00

Map

 Project objective

Platelets play an essential role in hemostasis but are also critically involved in acute arterial thrombotic occlusions leading to myocardial infarction or ischemic stroke and associated tissue fibrosis which are still the major cause of morbidity and disability in the European Union thus causing enormous costs in the health care system. In the last years there is increasing evidence that primary hemostasis and inflammatory atherothrombosis are crucially affected by leukocytes. Thereby the neutrophils represent the most abundant type of immune celly as almost 50% of all leukocytes belong to the neutrophil subset. The neutrophil extracellular trap (NET) formation is mainly know as pro-thrombotic factor in arterial thrombosis and is characterized by release of decondensed chromatin with incorporated histones and neutrophil elastases after neutrophil activation. Beside their pro-thrombotic effect, NETs were also recently described as inducer of tissue fibrosis in vivo thus contributing to cardiac tissue damage. Although tubulin and intermediate filament rearrangements in the cytoskeleton and nuclear envelope are a prerequisite for NET formation and chromatin release, nothing is know about the underlying molecular mechanisms and targets hitherto. Tubulin dynamics and microtubules are known regulators of intermediate filaments in the nuclear envelope thus maintaining the nuclear integrity of cells. Thereby, the ubiquitous Casein kinase 2 (CK2) is an acknowledged upstream molecule of microtubule dynamics and stability in a wide variety of cells. For this reason, the role of the CK2 in microtubule and intermediate filament dynamics during NET formation and its impact on thrombo-occlusive tissue fibrosis in cardiovascular diseases will be investigated resulting in the identification of new molecular structures suitable for improved and personalized treatment of thrombo-occlusive events like myocardial infarction and ischemic stroke.

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The information about "COAGULANT" are provided by the European Opendata Portal: CORDIS opendata.

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