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COAGULANT SIGNED

CK2-dependent cytoskeletal regulation and molecular signaling of Neutrophil Extracellular Trap (NET) formation

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 COAGULANT project word cloud

Explore the words cloud of the COAGULANT project. It provides you a very rough idea of what is the project "COAGULANT" about.

belong    intermediate    thrombosis    cardiovascular    ischemic    decondensed    thrombotic    kinase    enormous    subset    fibrosis    structures    upstream    molecule    rearrangements    abundant    neutrophils    events    nothing    beside    occlusive    immune    morbidity    occlusions    acknowledged    personalized    primary    filaments    nets    trap    envelope    care    neutrophil    tissue    acute    regulators    prerequisite    underlying    extracellular    stability    casein    50    mainly    union    incorporated    elastases    mechanisms    cytoskeleton    thereby    platelets    inducer    microtubules    tubulin    causing    molecular    cardiac    hitherto    pro    vivo    disability    critically    cells    arterial    leukocytes    infarction    thrombo    identification    ubiquitous    effect    maintaining    crucially    activation    hemostasis    net    ing    diseases    play    almost    nuclear    dynamics    stroke    damage    inflammatory    suitable    variety    release    last    ck2    celly    atherothrombosis    integrity    treatment    chromatin    myocardial    microtubule    histones    filament    health   

Project "COAGULANT" data sheet

The following table provides information about the project.

Coordinator
EBERHARD KARLS UNIVERSITAET TUEBINGEN 

Organization address
address: GESCHWISTER-SCHOLL-PLATZ
city: TUEBINGEN
postcode: 72074
website: www.uni-tuebingen.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 239˙860 €
 EC max contribution 239˙860 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-GF
 Starting year 2018
 Duration (year-month-day) from 2018-09-01   to  2021-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    EBERHARD KARLS UNIVERSITAET TUEBINGEN DE (TUEBINGEN) coordinator 239˙860.00
2    CHILDREN'S HOSPITAL CORPORATION US (BOSTON) partner 0.00

Map

 Project objective

Platelets play an essential role in hemostasis but are also critically involved in acute arterial thrombotic occlusions leading to myocardial infarction or ischemic stroke and associated tissue fibrosis which are still the major cause of morbidity and disability in the European Union thus causing enormous costs in the health care system. In the last years there is increasing evidence that primary hemostasis and inflammatory atherothrombosis are crucially affected by leukocytes. Thereby the neutrophils represent the most abundant type of immune celly as almost 50% of all leukocytes belong to the neutrophil subset. The neutrophil extracellular trap (NET) formation is mainly know as pro-thrombotic factor in arterial thrombosis and is characterized by release of decondensed chromatin with incorporated histones and neutrophil elastases after neutrophil activation. Beside their pro-thrombotic effect, NETs were also recently described as inducer of tissue fibrosis in vivo thus contributing to cardiac tissue damage. Although tubulin and intermediate filament rearrangements in the cytoskeleton and nuclear envelope are a prerequisite for NET formation and chromatin release, nothing is know about the underlying molecular mechanisms and targets hitherto. Tubulin dynamics and microtubules are known regulators of intermediate filaments in the nuclear envelope thus maintaining the nuclear integrity of cells. Thereby, the ubiquitous Casein kinase 2 (CK2) is an acknowledged upstream molecule of microtubule dynamics and stability in a wide variety of cells. For this reason, the role of the CK2 in microtubule and intermediate filament dynamics during NET formation and its impact on thrombo-occlusive tissue fibrosis in cardiovascular diseases will be investigated resulting in the identification of new molecular structures suitable for improved and personalized treatment of thrombo-occlusive events like myocardial infarction and ischemic stroke.

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The information about "COAGULANT" are provided by the European Opendata Portal: CORDIS opendata.

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