Explore the words cloud of the CholeraIndex project. It provides you a very rough idea of what is the project "CholeraIndex" about.
The following table provides information about the project.
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
|Coordinator Country||Switzerland [CH]|
|Total cost||1˙999˙988 €|
|EC max contribution||1˙999˙988 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2018-02-01 to 2023-01-31|
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|1||ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE||CH (LAUSANNE)||coordinator||1˙999˙988.00|
Cholera is one of the oldest infectious diseases known and remains a major burden in many developing countries. The World Health Organization estimates that up to 4 million cases of cholera occur annually. The transmission of cholera by contaminated water, particularly under epidemic conditions, was first reported in the 19th century. However, early volunteer studies suggested that an incredibly high infectious dose (ID) is required to produce disease symptoms, in contrast to most other intestinal pathogens. Therefore, the mechanism of infection of index cases at the onset of an outbreak is unclear. This proposal aims to fill this knowledge gap by studying how the environmental lifestyle of the causative agent of the disease, the bacterium Vibrio cholerae, may prime the pathogen for intestinal colonization. We hypothesize that one of the natural niches of the bacterium (chitinous surfaces) fosters biofilm formation and provides a competitive advantage over co-colonizing bacteria. As an adaptive trait, passage of chitin-attached sessile V. cholerae through the acidic environment of the human stomach might be vastly facilitated compared to planktonic bacteria. Moreover, interbacterial warfare exerted by V. cholerae on these biotic surfaces may help the pathogen overcome the colonization barrier imposed by the human microbiota upon ingestion. The mechanism by which V. cholerae leaves the sessile lifestyle and the regulatory circuits involved in this process will also be investigated in this project. In summary, our goal is to elucidate the environmental community structures of V. cholerae that may enhance transmissibility from the ecosystem to humans in endemic areas resulting in the infection of index cases.
|year||authors and title||journal||last update|
David Dubnau, Melanie Blokesch
Mechanisms of DNA Uptake by Naturally Competent Bacteria
published pages: ePub ahead of pr, ISSN: 0066-4197, DOI: 10.1146/annurev-genet-112618-043641
|Annual Review of Genetics 53/1||2020-04-24|
NoÃ©mie Matthey, Sandrine Stutzmann, Candice Stoudmann, Nicolas Guex, Christian Iseli, Melanie Blokesch
Neighbor predation linked to natural competence fosters the transfer of large genomic regions in Vibrio cholerae
published pages: epub ahead of rp, ISSN: 2050-084X, DOI: 10.7554/elife.48212
David W. Adams, Jorge M. Pereira, Candice Stoudmann, Sandrine Stutzmann, Melanie Blokesch
The type IV pilus protein PilU functions as a PilT-dependent retraction ATPase
published pages: e1008393, ISSN: 1553-7404, DOI: 10.1371/journal.pgen.1008393
|PLOS Genetics 15/9||2020-04-24|
Damien Piel, Maxime Bruto, AdÃ¨le James, Yannick Labreuche, Christophe Lambert, Adrian Janicot, Sabine Chenivesse, Bruno Petton, K. Mathias Wegner, Candice Stoudmann, Melanie Blokesch, FrÃ©dÃ©rique Le Roux
Selection of Vibrio crassostreae relies on a plasmid expressing a type 6 secretion system cytotoxic for host immune cells
published pages: , ISSN: 1462-2912, DOI: 10.1111/1462-2920.14776
|Environmental Microbiology ePub ahead of print||2020-04-24|
Charles Van der Henst, Audrey Sophie Vanhove, NatÃ¡lia Carolina Drebes DÃ¶rr, Sandrine Stutzmann, Candice Stoudmann, StÃ©phanie Clerc, Tiziana Scrignari, Catherine Maclachlan, Graham Knott, Melanie Blokesch
Molecular insights into Vibrio choleraeâ€™s intra-amoebal host-pathogen interactions
published pages: 3460, ISSN: 2041-1723, DOI: 10.1038/s41467-018-05976-x
|Nature Communications 9/1||2020-04-24|
NatÃ¡lia C. Drebes DÃ¶rr, Melanie Blokesch
Bacterial type VI secretion system facilitates niche domination
published pages: 8855-8857, ISSN: 0027-8424, DOI: 10.1073/pnas.1812776115
|Proceedings of the National Academy of Sciences 115/36||2020-04-24|
David. W. Adams, Sandrine Stutzmann, Candice Stoudmann, Melanie Blokesch
DNA-uptake pili of Vibrio cholerae are required for chitin colonization and capable of kin recognition via sequence-specific self-interaction
published pages: , ISSN: 2058-5276, DOI: 10.1038/s41564-019-0479-5
Lisa C. Metzger, NoÃ©mie Matthey, Candice Stoudmann, Esther J. Collas, Melanie Blokesch
Ecological implications of gene regulation by TfoX and TfoY among diverse Vibrio species
published pages: 2231-2247, ISSN: 1462-2912, DOI: 10.1111/1462-2920.14562
|Environmental Microbiology 21/7||2020-04-24|
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