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CholeraIndex SIGNED

Pathoecology of Vibrio cholerae to better understand cholera index cases in endemic areas

Total Cost €

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EC-Contrib. €

0

Partnership

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 CholeraIndex project word cloud

Explore the words cloud of the CholeraIndex project. It provides you a very rough idea of what is the project "CholeraIndex" about.

humans    annually    sessile    transmissibility    ingestion    barrier    biofilm    ing    exerted    incredibly    environment    transmission    unclear    niches    leaves    structures    microbiota    adaptive    id    bacterium    advantage    environmental    planktonic    gap    countries    circuits    stomach    surfaces    colonizing    co    bacteria    contaminated    epidemic    overcome    world    infectious    ecosystem    colonization    intestinal    elucidate    symptoms    water    warfare    summary    burden    onset    diseases    outbreak    chitinous    human    reported    estimates    fill    endemic    index    facilitated    provides    chitin    imposed    disease    cholera    competitive    health    volunteer    trait    causative    acidic    hypothesize    community    cholerae    interbacterial    prime    century    passage    oldest    pathogens    biotic    first    contrast    19th    fosters    agent    pathogen    vastly    dose    mechanism    attached    regulatory    lifestyle    infection    suggested    organization    natural    vibrio    million   

Project "CholeraIndex" data sheet

The following table provides information about the project.

Coordinator
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE 

Organization address
address: BATIMENT CE 3316 STATION 1
city: LAUSANNE
postcode: 1015
website: www.epfl.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 1˙999˙988 €
 EC max contribution 1˙999˙988 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-COG
 Funding Scheme ERC-COG
 Starting year 2018
 Duration (year-month-day) from 2018-02-01   to  2023-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE CH (LAUSANNE) coordinator 1˙999˙988.00

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 Project objective

Cholera is one of the oldest infectious diseases known and remains a major burden in many developing countries. The World Health Organization estimates that up to 4 million cases of cholera occur annually. The transmission of cholera by contaminated water, particularly under epidemic conditions, was first reported in the 19th century. However, early volunteer studies suggested that an incredibly high infectious dose (ID) is required to produce disease symptoms, in contrast to most other intestinal pathogens. Therefore, the mechanism of infection of index cases at the onset of an outbreak is unclear. This proposal aims to fill this knowledge gap by studying how the environmental lifestyle of the causative agent of the disease, the bacterium Vibrio cholerae, may prime the pathogen for intestinal colonization. We hypothesize that one of the natural niches of the bacterium (chitinous surfaces) fosters biofilm formation and provides a competitive advantage over co-colonizing bacteria. As an adaptive trait, passage of chitin-attached sessile V. cholerae through the acidic environment of the human stomach might be vastly facilitated compared to planktonic bacteria. Moreover, interbacterial warfare exerted by V. cholerae on these biotic surfaces may help the pathogen overcome the colonization barrier imposed by the human microbiota upon ingestion. The mechanism by which V. cholerae leaves the sessile lifestyle and the regulatory circuits involved in this process will also be investigated in this project. In summary, our goal is to elucidate the environmental community structures of V. cholerae that may enhance transmissibility from the ecosystem to humans in endemic areas resulting in the infection of index cases.

 Publications

year authors and title journal last update
List of publications.
2019 David Dubnau, Melanie Blokesch
Mechanisms of DNA Uptake by Naturally Competent Bacteria
published pages: ePub ahead of pr, ISSN: 0066-4197, DOI: 10.1146/annurev-genet-112618-043641
Annual Review of Genetics 53/1 2020-04-24
2019 Noémie Matthey, Sandrine Stutzmann, Candice Stoudmann, Nicolas Guex, Christian Iseli, Melanie Blokesch
Neighbor predation linked to natural competence fosters the transfer of large genomic regions in Vibrio cholerae
published pages: epub ahead of rp, ISSN: 2050-084X, DOI: 10.7554/elife.48212
eLife 8 2020-04-24
2019 David W. Adams, Jorge M. Pereira, Candice Stoudmann, Sandrine Stutzmann, Melanie Blokesch
The type IV pilus protein PilU functions as a PilT-dependent retraction ATPase
published pages: e1008393, ISSN: 1553-7404, DOI: 10.1371/journal.pgen.1008393
PLOS Genetics 15/9 2020-04-24
2019 Damien Piel, Maxime Bruto, Adèle James, Yannick Labreuche, Christophe Lambert, Adrian Janicot, Sabine Chenivesse, Bruno Petton, K. Mathias Wegner, Candice Stoudmann, Melanie Blokesch, Frédérique Le Roux
Selection of Vibrio crassostreae relies on a plasmid expressing a type 6 secretion system cytotoxic for host immune cells
published pages: , ISSN: 1462-2912, DOI: 10.1111/1462-2920.14776
Environmental Microbiology ePub ahead of print 2020-04-24
2018 Charles Van der Henst, Audrey Sophie Vanhove, Natália Carolina Drebes Dörr, Sandrine Stutzmann, Candice Stoudmann, Stéphanie Clerc, Tiziana Scrignari, Catherine Maclachlan, Graham Knott, Melanie Blokesch
Molecular insights into Vibrio cholerae’s intra-amoebal host-pathogen interactions
published pages: 3460, ISSN: 2041-1723, DOI: 10.1038/s41467-018-05976-x
Nature Communications 9/1 2020-04-24
2018 Natália C. Drebes Dörr, Melanie Blokesch
Bacterial type VI secretion system facilitates niche domination
published pages: 8855-8857, ISSN: 0027-8424, DOI: 10.1073/pnas.1812776115
Proceedings of the National Academy of Sciences 115/36 2020-04-24
2019 David. W. Adams, Sandrine Stutzmann, Candice Stoudmann, Melanie Blokesch
DNA-uptake pili of Vibrio cholerae are required for chitin colonization and capable of kin recognition via sequence-specific self-interaction
published pages: , ISSN: 2058-5276, DOI: 10.1038/s41564-019-0479-5
Nature Microbiology 2020-04-24
2019 Lisa C. Metzger, Noémie Matthey, Candice Stoudmann, Esther J. Collas, Melanie Blokesch
Ecological implications of gene regulation by TfoX and TfoY among diverse Vibrio species
published pages: 2231-2247, ISSN: 1462-2912, DOI: 10.1111/1462-2920.14562
Environmental Microbiology 21/7 2020-04-24

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The information about "CHOLERAINDEX" are provided by the European Opendata Portal: CORDIS opendata.

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