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GrapheneBiosensor SIGNED

Electrochemical Graphene Sensors as Early Alert Tools for Algal Toxin Detection in Water

Total Cost €

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EC-Contrib. €

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Partnership

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 GrapheneBiosensor project word cloud

Explore the words cloud of the GrapheneBiosensor project. It provides you a very rough idea of what is the project "GrapheneBiosensor" about.

warming    expensive    fit    concentration    demanding    massive    alternatives    liver    damage    waste    electrochemical    conventional    area    solutions    drinking    consuming    situ    run    biosensors    harmful    organization    mc    global    limit    sensitive    instruments    physical    had    portable    active    protein    toxic    followed    material    detergents    immune    guideline    1998    eutrophication    chromatography    microcystin    monitoring    water    rapid    quality    prolonged    algae    world    mu    urban    phosphatases    ing    contained    worldwide    prevent    responsible    skills    anthropogenic    animals    candidate    cyanobacteria    assays    confirmed    bodies    conductivity    death    agricultural    microcystins    times    sophisticated    algal    laboratory    off    functionalization    electrochemically    hemorrhage    manufacturing    graphene    potent    pp2a    ppl    exposure    purpose    immunosensors    health    electrical    sources    blooms    aqueous    blue    mass    2a    lr    time    episodes    frequently    acute    bio    ease    probably    assigned    intrahepatic    potentials    poisonings    humans    ms    liquid    provisional    occurrence    detect    toxin    inhibiting    performance    spectrometry    biochemical    broad    hplc    surface   

Project "GrapheneBiosensor" data sheet

The following table provides information about the project.

Coordinator
SWANSEA UNIVERSITY 

Organization address
address: SINGLETON PARK
city: SWANSEA
postcode: SA2 8PP
website: www.swan.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 195˙454 €
 EC max contribution 195˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-09-26   to  2019-11-07

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    SWANSEA UNIVERSITY UK (SWANSEA) coordinator 195˙454.00

Map

 Project objective

Episodes of harmful blue algae blooms and the associated algal toxin microcystin-LR (MC-LR) occur frequently in bodies of water worldwide as consequences of eutrophication resulting from anthropogenic activities such as agricultural run-off, urban waste, and manufacturing of detergents and global warming. It had been confirmed that microcystins were responsible for some poisonings of animals and humans where water sources contained toxic cyanobacteria blooms. Microcystins were potent and specific in inhibiting protein phosphatases 1 and 2A (PPl, PP2A). Acute or prolonged exposure to microcystins would cause liver damage, followed by a massive intrahepatic hemorrhage and probably leading to death. In 1998, the provisional guideline concentration limit of 1 μg/L MC-LR in drinking water was assigned by the World Health Organization (WHO). The development of reliable methods for monitoring MC-LR in water resources is of great interest to determine the occurrence and to prevent exposure to the toxin. Several methods have been developed to detect MC-LR, such as high-performance liquid chromatography/mass spectrometry (HPLC/MS) , bio-, biochemical- and immune-assays, which require long processing times, sophisticated instruments, complex procedures, or high processing cost and are in general used in the laboratory, not in situ. A sensitive, specific, simple, and rapid method for monitoring MC-LR could help to prevent exposure to the toxin. The unique physical and electrochemical properties (e.g., high electrical conductivity, ease of functionalization, high electrochemically active surface area, and broad range of working potentials in aqueous solutions) of graphene make them a candidate material for developing novel and fit-for-purpose electrochemical biosensors/immunosensors as alternatives to the time-consuming, expensive, non-portable and often skills-demanding conventional methods of analysis involved in water quality assessment.

 Publications

year authors and title journal last update
List of publications.
2018 Wei Zhang, Mike B. Dixon, Christopher Saint, Kar Seng Teng, Hiroaki Furumai
Electrochemical Biosensing of Algal Toxins in Water: The Current State-of-the-Art
published pages: 1233-1245, ISSN: 2379-3694, DOI: 10.1021/acssensors.8b00359
ACS Sensors 3/7 2020-02-27
2018 Wei Zhang, Baoping Jia, Hiroaki Furumai
Fabrication of graphene film composite electrochemical biosensor as a pre-screening algal toxin detection tool in the event of water contamination
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-28959-w
Scientific Reports 8/1 2020-02-27

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