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ADVaNCE SIGNED

ADVerse outcome Network for non-mutagenic CarcinogEns

Total Cost €

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EC-Contrib. €

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Partnership

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Project "ADVaNCE" data sheet

The following table provides information about the project.

Coordinator
EDELWEISS CONNECT GMBH 

Organization address
address: HOCHBERGERSTRASSE 60C
city: BASEL
postcode: 4057
website: http://www.douglasconnect.com/

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Project website https://github.com/tadoktor/HCC-study
 Total cost 187˙419 €
 EC max contribution 187˙419 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-SE
 Starting year 2017
 Duration (year-month-day) from 2017-10-01   to  2019-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    EDELWEISS CONNECT GMBH CH (BASEL) coordinator 187˙419.00

Map

 Project objective

The field of toxicology is evolving from purely descriptive to a highly data‐rich science. To structure this large amount of data and in this way make the usage more effective for the safety assessors, the concept of adverse outcome pathways was established providing a means of understanding how chemicals induce adverse effects through their toxicity pathways and modes of action. However, there are some doubts if the one initiating event - one adverse outcome relationship enforced on AOPs by the OECD guideline is able to cover more complex adverse effects like hepatocellular carcinoma resulting from non-mutagenic chemical exposure. Therefore, the ADVaNCE project will demonstrate based on the just mentioned example that combining all existing knowledge into an adverse outcome network formed by interlinked AOPs is needed to cover all the pathways and intervention points activated in order to contribute to the development of hepatocellular carcinomas. Computational approaches will be used to extract important key events and their relationships from existing data sources and the relevant literature. These will be compared with existing AOPs and further experimental validation will be started. The computational and experimental result will finally guide the development of an integrated testing strategy completely based on in silico and in vitro data, which development and validation regarding regulatory usage will be continued after the project.

 Publications

year authors and title journal last update
List of publications.
2018 Oana Florean, Lucian Farcal, Noffisat Oki, Thomas Exner, Barry Hardy and Tatyana Doktorova
Use of publicly available transcriptomics data to support the steatosis AOP development
published pages: , ISSN: 1868-596X, DOI:
2020-04-14
2019 Tatyana Y. Doktorova, Noffisat O. Oki, Tomaž Mohorič, Thomas E. Exner, Barry Hardy
An automated workflow for Adverse Outcome Pathway hypothesis generation: the use case of non-genotoxic induced hepatocellular carcinoma
published pages: , ISSN: 0273-2300, DOI:
Regulatory Toxicology and Pharmacology (submitted) 2020-04-14
2019 Noffisat O. Oki, Lucian Farcal, Ahmed Abdelaziz, Oana Florean, Tatyana Y. Doktorova, Thomas Exner, Pekka Kohonen, Roland Grafström, Barry Hardy
Integrated analysis of in vitro data and the adverse outcome pathway framework for prioritization and regulatory applications: An exploratory case study using publicly available data on piperonyl butoxide and liver models
published pages: 23-32, ISSN: 0887-2333, DOI: 10.1016/j.tiv.2018.09.002
Toxicology in Vitro 54 2020-04-14

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The information about "ADVANCE" are provided by the European Opendata Portal: CORDIS opendata.

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