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5D Heart Patch SIGNED

A Functional, Mature In vivo Human Ventricular Muscle Patch for Cardiomyopathy

Total Cost €

EC-Contrib. €

Partnership

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5D Heart Patch project word cloud

Explore the words cloud of the 5D Heart Patch project. It provides you a very rough idea of what is the project "5D Heart Patch" about.

strategies differentiation arrhythmogenic vascularized extracellular surface difficult medicine generation vascularization infarction captalize pure muscle paracrine human models self mature regeneration autonomous model cell expression chimeric compensate cells developing post grafting hpsc maturation epicardial massive heart functional central proven survival purified drive purification hvps found protocol cardiac experimental paradigm implantation disease optimize matrix vitro cardiomyopathy facs hvp graft localized ischemic biology assembly engineers cardiomyocytes ventricular therapeutic stem tissue generate progenitors modrna injured assemble organ identification pluripotent billions patch myocardial expansion 3d receptors vivo

Project "5D Heart Patch" data sheet

The following table provides information about the project.

Coordinator	KAROLINSKA INSTITUTET Organization address address: Nobels Vag 5 city: STOCKHOLM postcode: 17177 website: www.ki.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Sweden [SE]
Total cost	2˙149˙227 €
EC max contribution	2˙149˙227 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2016-ADG
Funding Scheme	ERC-ADG
Starting year	2017
Duration (year-month-day)	from 2017-12-01 to 2022-11-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	KAROLINSKA INSTITUTET KAROLINSKA INSTITUTET Organization address address: Nobels Vag 5 city: STOCKHOLM postcode: 17177 website: www.ki.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (STOCKHOLM)	coordinator	2˙149˙227.00

Map

Project objective

Developing new therapeutic strategies for heart regeneration is a major goal for cardiac biology and medicine. While cardiomyocytes can be generated from human pluripotent stem (hPSC) cells in vitro, it has proven difficult to use these cells to generate a large scale, mature human heart ventricular muscle graft on the injured heart in vivo. The central objective of this proposal is to optimize the generation of a large-scale pure, fully functional human ventricular muscle patch in vivo through the self-assembly of purified human ventricular progenitors and the localized expression of defined paracrine factors that drive their expansion, differentiation, vascularization, matrix formation, and maturation. Recently, we have found that purified hPSC-derived ventricular progenitors (HVPs) can self-assemble in vivo on the epicardial surface into a 3D vascularized, and functional ventricular patch with its own extracellular matrix via a cell autonomous pathway. A two-step protocol and FACS purification of HVP receptors can generate billions of pure HVPs- The current proposal will lead to the identification of defined paracrine pathways to enhance the survival, grafting/implantation, expansion, differentiation, matrix formation, vascularization and maturation of the graft in vivo. We will captalize on our unique HVP system and our novel modRNA technology to deliver therapeutic strategies by using the in vivo human ventricular muscle to model in vivo arrhythmogenic cardiomyopathy, and optimize the ability of the graft to compensate for the massive loss of functional muscle during ischemic cardiomyopathy and post-myocardial infarction. The studies will lead to new in vivo chimeric models of human cardiac disease and an experimental paradigm to optimize organ-on-organ cardiac tissue engineers of an in vivo, functional mature ventricular patch for cardiomyopathy

Publications

List of publications.
year	authors and title	journal	last update
2018	Kylie S. Foo, Miia L. Lehtinen, Chuen Yan Leung, Xiaojun Lian, Jiejia Xu, Wendy Keung, Lin Geng, Terje R.S. Kolstad, Sebastian Thams, Andy On-tik Wong, Nicodemus Wong, Kristine Bylund, Chikai Zhou, Xiaobing He, Shao-Bo Jin, Jonathan Clarke, Urban Lendahl, Ronald A. Li, William E. Louch, Kenneth R. Chien Human ISL1 + Ventricular Progenitors Self-Assemble into an InÂ Vivo Functional Heart Patch and Preserve Cardiac Function Post Infarction published pages: 1644-1659, ISSN: 1525-0016, DOI: 10.1016/j.ymthe.2018.02.012	Molecular Therapy 26/7	2019-08-29

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The information about "5D HEART PATCH" are provided by the European Opendata Portal: CORDIS opendata.