Explore the words cloud of the ExoDia project. It provides you a very rough idea of what is the project "ExoDia" about.
The following table provides information about the project.
CENTRE EUROPEEN D'ETUDE DU DIABETE
|Coordinator Country||France [FR]|
|Total cost||185˙076 €|
|EC max contribution||185˙076 € (100%)|
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
|Duration (year-month-day)||from 2018-01-02 to 2020-01-01|
Take a look of project's partnership.
|1||CENTRE EUROPEEN D'ETUDE DU DIABETE||FR (STRASBOURG)||coordinator||185˙076.00|
The worldwide explosion of obesity has resulted in an ever-increasing prevalence of type 2 diabetes (T2D), a non-communicable disease that affects more than 370 million people worldwide. T2D is characterized by insulin resistance with a relative deficiency in insulin secretion. It is now recognized that there is decreased beta-cell function and mass in T2D but the precise underlying mechanism remains to be determined. Skeletal muscle accounts for >50% of the total glucose uptake in the post-prandial state, it is also the largest organ in non-obese individuals. Recent studies demonstrated that there is conversation between skeletal muscle and beta-cells, and that certain peptides (i.e. myokines) secreted by insulin-resistant skeletal muscle cells may impact negatively on beta-cell function, proliferation and survival in T2D. Nevertheless, other factors than myokines could also be involved in this inter-organ communication. A novel concept suggests microvesicles, such as exosomes, as a new cell-to-cell communication mode. The major goal of the project will be to characterize the different exosomes populations and their impact on islets cells. The findings may have important implications for understanding decreased functional beta-cell mass in diabetes, especially in T2D etiology, and therefore bring new insights into the development of innovative therapies. To achieve the aims of the innovative translational project, the candidate will be part of one of the European leader research centres on diabetes, trained to promising new research area in inter-organ communication, micro-RNA biology, as well as cutting-edge 'omic' technologies which will perfectly complement her strong knowledge in energy metabolism and physiology and create a rare expertise in candidate's profile. It will provide a unique stepping-stone for her independent research career in Europe and successful collaborations in the future.
|year||authors and title||journal||last update|
Maria L. Mizgier, Rodrigo FernÃ¡ndez-Verdejo, Julien Cherfan, Michel Pinget, Karim Bouzakri, Jose E. Galgani
Insights on the Role of Putative Muscle-Derived Factors on Pancreatic Beta Cell Function
published pages: , ISSN: 1664-042X, DOI: 10.3389/fphys.2019.01024
|Frontiers in Physiology 10||2019-11-22|
Sophie Rome, Alexis Forterre, Maria Luisa Mizgier, Karim Bouzakri
Skeletal Muscle-Released Extracellular Vesicles: State of the Art
published pages: , ISSN: 1664-042X, DOI: 10.3389/fphys.2019.00929
|Frontiers in Physiology 10||2019-11-22|
Are you the coordinator (or a participant) of this project? Plaese send me more information about the "EXODIA" project.
For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.
Send me an email (email@example.com) and I put them in your project's page as son as possible.
Thanks. And then put a link of this page into your project's website.
The information about "EXODIA" are provided by the European Opendata Portal: CORDIS opendata.
Increasing the scope of CO2-utilising photoreactions: asymmetric photosynthesis of amino acidsRead More
Multi-color and single-molecule fluorescence imaging of intraflagellar transport in the phasmid chemosensory cilia of C. ElegansRead More
Mathematics AnalogiesRead More