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ExoDia SIGNED

Cross-talk between skeletal muscle and pancreatic islets: impact of exosomes

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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0

 ExoDia project word cloud

Explore the words cloud of the ExoDia project. It provides you a very rough idea of what is the project "ExoDia" about.

inter    mass    expertise    mode    technologies    individuals    innovative    collaborations    resistant    function    area    perfectly    profile    beta    determined    communication    accounts    islets    omic    therapies    post    relative    career    survival    nevertheless    insights    stone    t2d    skeletal    secretion    rna    energy    resistance    microvesicles    leader    disease    micro    50    prevalence    cell    translational    complement    etiology    precise    peptides    decreased    muscle    worldwide    glucose    mechanism    centres    rare    prandial    candidate    physiology    trained    secreted    insulin    obesity    deficiency    successful    underlying    independent    stepping    populations    total    cells    create    million    ed    proliferation    conversation    implications    functional    people    organ    370    exosomes    communicable    diabetes    edge    cutting    negatively    explosion    certain    gt    suggests    myokines    metabolism    obese    demonstrated    biology   

Project "ExoDia" data sheet

The following table provides information about the project.

Coordinator
CENTRE EUROPEEN D'ETUDE DU DIABETE 

Organization address
address: BOULEVARD RENE LERICHE
city: STRASBOURG
postcode: 67200
website: www.ceed-diabete.org

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 185˙076 €
 EC max contribution 185˙076 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-SE
 Starting year 2018
 Duration (year-month-day) from 2018-01-02   to  2020-01-01

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE EUROPEEN D'ETUDE DU DIABETE FR (STRASBOURG) coordinator 185˙076.00

Map

 Project objective

The worldwide explosion of obesity has resulted in an ever-increasing prevalence of type 2 diabetes (T2D), a non-communicable disease that affects more than 370 million people worldwide. T2D is characterized by insulin resistance with a relative deficiency in insulin secretion. It is now recognized that there is decreased beta-cell function and mass in T2D but the precise underlying mechanism remains to be determined. Skeletal muscle accounts for >50% of the total glucose uptake in the post-prandial state, it is also the largest organ in non-obese individuals. Recent studies demonstrated that there is conversation between skeletal muscle and beta-cells, and that certain peptides (i.e. myokines) secreted by insulin-resistant skeletal muscle cells may impact negatively on beta-cell function, proliferation and survival in T2D. Nevertheless, other factors than myokines could also be involved in this inter-organ communication. A novel concept suggests microvesicles, such as exosomes, as a new cell-to-cell communication mode. The major goal of the project will be to characterize the different exosomes populations and their impact on islets cells. The findings may have important implications for understanding decreased functional beta-cell mass in diabetes, especially in T2D etiology, and therefore bring new insights into the development of innovative therapies. To achieve the aims of the innovative translational project, the candidate will be part of one of the European leader research centres on diabetes, trained to promising new research area in inter-organ communication, micro-RNA biology, as well as cutting-edge 'omic' technologies which will perfectly complement her strong knowledge in energy metabolism and physiology and create a rare expertise in candidate's profile. It will provide a unique stepping-stone for her independent research career in Europe and successful collaborations in the future.

 Publications

year authors and title journal last update
List of publications.
2019 Maria L. Mizgier, Rodrigo Fernández-Verdejo, Julien Cherfan, Michel Pinget, Karim Bouzakri, Jose E. Galgani
Insights on the Role of Putative Muscle-Derived Factors on Pancreatic Beta Cell Function
published pages: , ISSN: 1664-042X, DOI: 10.3389/fphys.2019.01024
Frontiers in Physiology 10 2019-11-22
2019 Sophie Rome, Alexis Forterre, Maria Luisa Mizgier, Karim Bouzakri
Skeletal Muscle-Released Extracellular Vesicles: State of the Art
published pages: , ISSN: 1664-042X, DOI: 10.3389/fphys.2019.00929
Frontiers in Physiology 10 2019-11-22

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