Opendata, web and dolomites

InflamCellDeath SIGNED

Mechanism and function of gasdermin-induced inflammatory cell death

Total Cost €


EC-Contrib. €






 InflamCellDeath project word cloud

Explore the words cloud of the InflamCellDeath project. It provides you a very rough idea of what is the project "InflamCellDeath" about.

generates    activated    antimicrobial    comprehensively    release    chronic    plasma    cytotoxic    pyroptotic    causes    family    dependent    programmed    mechanism    pathogen    cleavage    caspase    noxious    host    bacterial    platforms    cytosolic    detrimental    forms    function    pattern    gasdermin    receptors    innate    necrotic    infectious    recognition    terminal    pore    disease    signals    members    proteases    pro    single    elucidate    concomitant    regulators    inflammation    substrate    cytokines    repair    diseases    lytic    defense    gasdermins    signalling    microbial    inflammatory    fragment    characterizing    substances    membrane    effectors    restricting    infection    permeability    immune    found    larger    pores    pyroptosis    inflammasomes    inflammasome    leaderless    group    regulate    forming    assembled    appear    therapies    caspases    detection    anti    danger    injury    promotes    activation    death    regulation    protein    cell    share    caused   

Project "InflamCellDeath" data sheet

The following table provides information about the project.


Organization address
address: Quartier Unil-Centre Bâtiment Unicentre
postcode: 1015

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 1˙999˙176 €
 EC max contribution 1˙999˙176 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-COG
 Funding Scheme ERC-COG
 Starting year 2018
 Duration (year-month-day) from 2018-03-01   to  2023-02-28


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE DE LAUSANNE CH (LAUSANNE) coordinator 1˙999˙176.00


 Project objective

Pyroptosis is a lytic pro-inflammatory type of programmed cell death that is induced by inflammatory caspases, a family of proteases that control the innate immune response to infection, injury or noxious substances. Inflammatory caspases are activated within so-called inflammasomes, cytosolic signalling platforms that are assembled by pattern recognition receptors upon the detection of pathogen- or host-derived danger signals. Pyroptosis is essential for antimicrobial host defense, but also promotes the concomitant release of inflammatory danger signals and leaderless cytokines that is detrimental during chronic inflammatory disease.

Recently it was found that pyroptosis is caused by the cleavage of a single caspase substrate called gasdermin-D. This cleavage generates a cytotoxic N-terminal fragment of gasdermin-D that targets the plasma membrane, where it forms large permeability pores and thus causes pyroptotic cell death. Gasdermin-D is only one member of the larger gasdermin protein family, an emerging group of cell death effectors that share its pore-forming cytotoxic activity and that appear to be major regulators of inflammatory necrotic cell death.

The main goal of this proposal is to comprehensively characterize the function of gasdermins in anti-microbial host defense, to investigate the consequences of gasdermin-D pore formation to the host cell and to elucidate the pathways that regulate gasdermin activation. My objectives are:

1) to define the role of gasdermin-D in inflammasome-dependent anti-bacterial host defense 2) to study the role of membrane repair in restricting gasdermin-D-induced membrane 3) to characterize the function and regulation of other gasdermin family members during infection

By characterizing the mechanism and function of gasdermin-induced cell death in host-defense and inflammation this project may contribute to the development of novel therapies for infectious as well as inflammatory diseases.


year authors and title journal last update
List of publications.
2018 Sebastian Rühl, Kateryna Shkarina, Benjamin Demarco, Rosalie Heilig, José Carlos Santos, Petr Broz
ESCRT-dependent membrane repair negatively regulates pyroptosis downstream of GSDMD activation
published pages: 956-960, ISSN: 0036-8075, DOI: 10.1126/science.aar7607
Science 362/6417 2019-10-07
2019 Kaiwen W. Chen, Benjamin Demarco, Petr Broz
Pannexin‐1 promotes NLRP3 activation during apoptosis but is dispensable for canonical or noncanonical inflammasome activation
published pages: , ISSN: 0014-2980, DOI: 10.1002/eji.201948254
European Journal of Immunology 2019-10-07
2019 Kaiwen W. Chen, Dave Boucher, Petr Broz
Divide to conquer: NLRP3 is activated on dispersed trans-Golgi network
published pages: 181-182, ISSN: 1001-0602, DOI: 10.1038/s41422-018-0138-z
Cell Research 29/3 2019-10-07
2019 Kaiwen W Chen, Benjamin Demarco, Rosalie Heilig, Kateryna Shkarina, Andreas Boettcher, Christopher J Farady, Pawel Pelczar, Petr Broz
Extrinsic and intrinsic apoptosis activate pannexin‐1 to drive NLRP 3 inflammasome assembly
published pages: , ISSN: 0261-4189, DOI: 10.15252/embj.2019101638
The EMBO Journal 38/10 2019-10-07
2019 Benjamin Demarco, Kaiwen W. Chen, Petr Broz
Pannexin-1 channels bridge apoptosis to NLRP3 inflammasome activation
published pages: 1610324, ISSN: 2372-3556, DOI: 10.1080/23723556.2019.1610324
Molecular & Cellular Oncology 6/4 2019-10-07

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "INFLAMCELLDEATH" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email ( and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "INFLAMCELLDEATH" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

DINAMIX (2019)

Real-time diffusion NMR analysis of mixtures

Read More  

EAST (2020)

Using Evolutionary Algorithms to Understand and Secure Web/Enterprise Systems

Read More  

CONTROL (2019)

Laser control over crystal nucleation

Read More