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MicroMOUPE SIGNED

Microscopy - Making optimal use of photons and electrons

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 MicroMOUPE project word cloud

Explore the words cloud of the MicroMOUPE project. It provides you a very rough idea of what is the project "MicroMOUPE" about.

microscopy    molecules    specimens    aberration    ponderomotive    technologically    evading    optimal    resolution    vienna    dna    pattern    switch    enhancement    modern    signal    zernike    pulses    multiple    optics    pass    coherent    microscopes    self    noise    of    tested    interactions    specimen    particles    fast    temporal    particle    blanking    quadratic    scattered    arbitrary    introducing    detection    experiment    cavities    cells    plate    generator    free    sensitivity    sensitive    created    imaging    proteins    landscapes    photons    bright    demonstrated    designed    times    probe    laser    electrons    post    shape    limit    microscope    intense    limited    nanoparticles    fundamental    single    university    interact    optically    dark    overcoming    linear    electron    shot    accuracy    stanford    optimize    beam    feasible    limits    potentials    spatial    sub    proof    adaptive    realized    nanometric    metal    optical    tool    creation    correction    electro   

Project "MicroMOUPE" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAT WIEN 

Organization address
address: UNIVERSITATSRING 1
city: WIEN
postcode: 1010
website: www.univie.ac.at

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Austria [AT]
 Project website https://imaging.univie.ac.at/
 Total cost 1˙672˙752 €
 EC max contribution 1˙672˙752 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2018
 Duration (year-month-day) from 2018-03-01   to  2023-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAT WIEN AT (WIEN) coordinator 1˙672˙752.00

Map

 Project objective

The sensitivity of modern microscopy is limited by shot-noise. It limits the accuracy of measurements of specimen properties as well as the spatial resolution of electron microscopes when imaging sensitive specimens, such as proteins or DNA. But the shot-noise limit is not a fundamental limit. A technologically feasible and optimal approach to overcoming the shot-noise limit is to have each probe particle interact with the specimen multiple times. We recently introduced this concept to microscopy using self-imaging cavities. Within this project, I want to demonstrate post-selection free sub-shot noise microscopy with both photons and electrons. Optically this will be possible by introducing a fast electro-optical switch into a multi-pass microscope, evading the need for temporal post-selection. After this proof-of principle experiment, the sensitivity enhancement offered by multi-pass microscopy shall be applied to the detection of nanometric particles, such as single molecules, proteins and metal nanoparticles. Linear signal enhancement with the number of interactions is expected for bright-field microscopy. For dark-field microscopy a quadratic enhancement is expected, due to coherent build-up of scattered fields. Finally, adaptive optics will be used to optimize multi-pass microscopy for the study of cells. Multi-pass electron microscopy will be realized in collaboration with Stanford University. It will require several novel electron optical elements that will be designed and tested both at Stanford University and at the University of Vienna. One of these elements will be a pattern generator for electrons based on ponderomotive potentials. The required potential landscapes will be created using adaptive optics to shape intense laser pulses. With this novel electron optics tool fast beam-blanking, a phase plate for Zernike phase microscopy, arbitrary pattern creation and aberration correction will be demonstrated.

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The information about "MICROMOUPE" are provided by the European Opendata Portal: CORDIS opendata.

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