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EMBRACE SIGNED

Elucidating Mechanisms of Bladder Cancer Metastasis

Total Cost €

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EC-Contrib. €

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Partnership

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Project "EMBRACE" data sheet

The following table provides information about the project.

Coordinator
ACADEMISCH ZIEKENHUIS LEIDEN 

Organization address
address: ALBINUSDREEF 2
city: LEIDEN
postcode: 2333 ZA
website: www.lumc.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 177˙598 €
 EC max contribution 177˙598 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-09-01   to  2020-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ACADEMISCH ZIEKENHUIS LEIDEN NL (LEIDEN) coordinator 177˙598.00

Map

 Project objective

Bladder cancer is the ninth most afflicted cancer in the world which affects people in both developing and developed countries; and European nations have some of the highest incidences. Poor prognosis and mortality rate is very often linked to formation of secondary tumour sites in these patients. In advanced stages of this cancer, cells strive to invade nearby tissues in a process called metastasis. More often than not, patients suffer more due to metastasis of cancer than through the original tumour. In this project, I will investigate the mechanisms which lead to bladder cancer metastasis; identify key components in the pathways and also test out specific inhibitors to mitigate the growth and/or metastasis. Having an acute knowledge of ‘how and which’ pathway(s) promote metastasis in bladder cancer should provide us with information so that specific components can be targeted. Moreover, the proposed study also focuses on developing state-of-the-art biomarker strategies to identify patient populations which will best benefit from our inhibitor therapies. This project will enable the translation of experimental results obtained from lab bench to understanding how some patients will best benefit from certain inhibitor therapies.

 Publications

year authors and title journal last update
List of publications.
2019 Wen Jing Sim, Prasanna Vasudevan Iyengar, Dilraj Lama, Sarah Kit Leng Lui, Hsien Chun Ng, Lior Haviv-Shapira, Eytan Domany, Dennis Kappei, Tuan Zea Tan, Azad Saei, Patrick William Jaynes, Chandra Shekhar Verma, Alan Prem Kumar, Mathieu Rouanne, Hong Koo Ha, Camelia Radulescu, Peter ten Dijke, Pieter Johan Adam Eichhorn and Jean Paul Thiery
c-Met activation leads to the establishment of a TGFβ-receptor regulatory network in bladder cancer progression
published pages: , ISSN: 2041-1723, DOI:
Nature Communications 2020-02-06
2020 Sijia Liu, Román González-Prieto, Mengdi Zhang, Paul P. Geurink, Raymond Kooij, Prasanna Vasudevan Iyengar, Maarten van Dinther, Erik Bos, Xiaobing Zhang, Sylvia E. Le Dévédec, Bob van de Water, Roman I. Koning, Hong-Jian Zhu, Wilma E. Mesker, Alfred C.O. Vertegaal, Huib Ovaa, Long Zhang, John W.M. Martens and Peter ten Dijke
Deubiquitinase Activity Profiling Identifies UCHL1 as a Candidate Oncoprotein That Promotes TGFβ-Induced Breast Cancer Metastasis
published pages: , ISSN: 1078-0432, DOI:
Clinical Cancer Research 2020-02-06
2019 Sudha Suriyamurthy, David Baker, Peter ten Dijke and Prasanna Vasudevan Iyengar*
Epigenetic Reprogramming of TGF-β Signaling in Breast Cancer
published pages: , ISSN: 2072-6694, DOI:
Cancers 2020-02-06

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The information about "EMBRACE" are provided by the European Opendata Portal: CORDIS opendata.

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